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Return side effects of high doses of prozac to top Prozac is prescribed for the treatment of depression--that side effects of high doses of prozac is, a continuing depression that interferes with daily functioning. The symptoms of major depression often include changes in appetite, sleep habits, and mind/body coordination; decreased sex drive; increased fatigue; feelings of guilt or worthlessness; difficulty concentrating; slowed thinking; and suicidal thoughts. Prozac is also prescribed to treat obsessive-compulsive disorder. An obsession is a thought that won't go away; a compulsion is an action done over and over to relieve anxiety. The side effects of high doses of prozac drug is side effects of high doses of prozac also used in the treatment of bulimia (binge-eating followed by deliberate vomiting). It has also been used to treat other eating disorders and obesity. In addition, Prozac is used to treat panic disorder, including panic associated with side effects of high doses of prozac agoraphobia (a side effects of high doses of prozac severe side effects of high doses of prozac fear of being in crowds or public places). People with panic disorder usually suffer from panic attacks--feelings of intense fear that develop suddenly, often for no reason. Various symptoms occur side effects of high doses of prozac during the attacks, including a rapid or pounding heartbeat, chest pain, sweating, trembling, and shortness of breath. In children and adolescents, Prozac is used to treat major depression and obsessive-compulsive disorder. Under the brand name Sarafem, the active ingredient in Prozac is also prescribed for the treatment of premenstrual dysphoric disorder (PMDD), formerly known as premenstrual syndrome (PMS). Symptoms side effects of high doses of prozac of PMDD include mood problems such as anxiety, depression, irritability or persistent anger, mood swings, and tension. Physical problems that accompany PMDD include bloating, breast tenderness, headache, and joint and muscle pain. Symptoms typically begin 1 to 2 weeks before a woman's menstrual period and are severe enough to interfere with day-to-day activities and relationships. Prozac is a member of the family of drugs called "selective serotonin re-uptake inhibitors." Serotonin is one of the chemical messengers believed to govern moods. Ordinarily, it is quickly reabsorbed after its release at the junctures between nerves. Re-uptake inhibitors such as Prozac slow this process, thereby boosting side effects of high doses of prozac the levels of serotonin available in the brain. Most important side effects of high doses of prozac fact about this drug Return to top Serious, sometimes fatal, side effects of high doses of prozac reactions have been known to occur when Prozac is used in combination with other side effects of high doses of prozac antidepressant drugs known as MAO inhibitors, side effects of high doses of prozac including Nardil and Parnate; and when Prozac is discontinued and an MAO inhibitor is started. Never take Prozac with one of these drugs or within at least 14 days of discontinuing therapy with one of them; and side effects of high doses of prozac allow 5 weeks or more between stopping Prozac and starting an MAO inhibitor. Be especially cautious if you have been taking Prozac in high side effects of high doses of prozac doses or side effects of high doses of prozac for a long time. If you are taking any prescription or nonprescription drugs, notify your doctor before taking Prozac. How should you take this medication? Return to top Prozac should be taken exactly as prescribed by your doctor. Prozac usually is taken once or twice a day. To be effective, it should be side effects of high doses of prozac taken regularly. Make a habit of taking it at the same time you do some other daily activity. side effects of high doses of prozac It may be 4 weeks before you feel any relief from your depression, but the drug's effects should last about 9 months after a 3-month treatment regimen. For obsessive-compulsive disorder, the side effects of high doses of prozac full effect may take 5 weeks to appear. --If you miss a dose... Take the forgotten dose side effects of high doses of prozac as soon as you remember. If several side effects of high doses of prozac hours have passed, skip the dose. Never try to "catch up" by doubling the dose. --Storage instructions... Store at room temperature. What side effects may occur? Return to top Side side effects of high doses of prozac effects side effects of high doses of prozac cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your side effects of high doses of prozac doctor can determine if it is safe for you to continue taking Prozac. More common side effects may include: Abnormal dreams, abnormal ejaculation, abnormal vision, anxiety, diminished sex drive, dizziness, dry mouth, flu-like symptoms, flushing, gas, headache, impotence, insomnia, itching, loss of appetite, nausea, nervousness, rash, sinusitis, sleepiness, sore throat, sweating, tremors, upset stomach, vomiting, weakness, yawning Less common side effects may include: side effects of high doses of prozac Abnormal taste, agitation, bleeding problems, side effects of high doses of prozac chills, confusion, ear pain, emotional instability, fever, frequent urination, high blood pressure, increased appetite, loss of memory, palpitations, ringing in the ears, sleep disorders, side effects of high doses of prozac weight gain In children and adolescents, less common side effects may also include: Agitation, excessive menstrual bleeding, frequent urination, hyperactivity, mania or side effects of high doses of prozac hypomania (inappropriate feelings of elation and/or side effects of high doses of prozac rapid thoughts), nosebleeds, personality changes, and thirst A wide variety of other very rare reactions have been reported during Prozac therapy. If you develop any new or unexplained symptoms, tell side effects of high doses of prozac your doctor without delay. Why should this drug not be prescribed? Return to top If you are sensitive to or have ever had an allergic reaction to Prozac or similar drugs such as Paxil and Zoloft, you side effects of high doses of prozac should not take this medication. Make sure that your doctor is aware of any drug reactions that you have experienced. Do not take this drug while using an MAO inhibitor. (See "Most important fact about this drug.") You should also not side effects of high doses of prozac use Prozac if you are taking Mellaril side effects of high doses of prozac (thioridazine). Likewise, do not start taking Mellaril within 5 weeks of stopping Prozac. Special warnings about this medication Return to top side effects of high doses of prozac Unless you are directed to do so by your doctor, do not take this medication if you are recovering from a heart attack or if you have liver disease or side effects of high doses of prozac diabetes. Prozac may cause you to become drowsy or side effects of high doses of prozac less alert side effects of high doses of prozac and may affect your judgment. Therefore, driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended. While taking this medication, you may feel dizzy or light-headed or actually faint when getting up from a lying or sitting position. If getting up slowly doesn't help or if this problem continues, notify your doctor. If you develop a skin rash or hives while taking Prozac, discontinue use of the medication and notify your doctor immediately. Prozac should be used with caution if you have a history of seizures. side effects of high doses of prozac You should discuss all of your medical conditions with your doctor before taking this medication. Prozac can occasionally cause decreased appetite and weight loss, especially in depressed people who are already underweight and in those with bulimia. If you notice changes in your weight or appetite, tell your doctor. Possible food and drug interactions when taking this medication Return to top Combining Prozac with MAO inhibitors or Mellaril (thioridazine) is dangerous. Do not drink alcohol while taking this medication. side effects of high doses of prozac If Prozac is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Prozac with the following: Alprazolam (Xanax) Carbamazepine (Tegretol) Clozapine (Clozaril) Diazepam (Valium) Digitoxin (Crystodigin) Drugs that impair brain function, such as sleep aids and narcotic painkillers Flecainide (Tambocor) Haloperidol (Haldol) Lithium (Eskalith) Other antidepressants side effects of high doses of prozac (Elavil) Phenytoin (Dilantin) Pimozide (Orap) Tryptophan Vinblastine (Velban) Warfarin (Coumadin) Special information if you are pregnant or breastfeeding Return to top The effects of Prozac during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. This medication side effects of high doses of prozac appears in breast milk, and breastfeeding side effects of high doses of prozac is not recommended while you are taking Prozac. side effects of high doses of prozac Recommended dosage Return to top ADULTS The usual starting dose is 20 side effects of high doses of prozac milligrams per day, taken in the morning. Your doctor may increase your dose after several weeks if no improvement is observed. People with kidney or liver disease, the elderly, and those taking side effects of high doses of prozac other drugs may have their dosages adjusted by their doctor. side effects of high doses of prozac Dosages above 20 milligrams daily should be taken once a day in the morning or in 2 smaller doses taken in the morning and at noon. The usual daily dose for depression side effects of high doses of prozac ranges from 20 to 60 milligrams. For obsessive-compulsive disorder the customary range is 20 to 60 milligrams per day, though side effects of high doses of prozac a maximum of 80 milligrams is sometimes prescribed. side effects of high doses of prozac For bulimia nervosa, the usual dose is 60 milligrams, taken in the morning. side effects of high doses of prozac Your doctor may have you start with less and build up to side effects of high doses of prozac this dosage. side effects of high doses of prozac The usual dose for premenstrual dysphoric disorder is 20 milligrams a day. For depression, it may take up to side effects of high doses of prozac 4 weeks before the full effects of the medication are seen. For obsessive-compulsive disorder, treatment can take 5 weeks or more to be effective. If you are taking a 20-milligram daily side effects of high doses of prozac dose of Prozac for depression, the doctor may switch you to a delayed-release formulation called Prozac Weekly. To make the change, you'll be asked to skip your daily dose for 7 days, then take your first weekly capsule. CHILDREN The usual starting dose for depression is 10 or 20 milligrams a day. After 1 week at 10 milligrams a day, the doctor side effects of high doses of prozac may increase the dose to 20 milligrams. It may take up to 4 weeks before the full effects of the medication are seen. For obsessive-compulsive disorder, the usual starting dose is 10 milligrams a day. After 2 weeks, the doctor may increase the dose to 20 side effects of high doses of prozac milligrams. If no improvement is seen after side effects of high doses of prozac several weeks, the side effects of high doses of prozac dosage may be increased as needed, up to a maximum of 60 milligrams a day. Treatment may take 5 weeks or more to be effective. Children who are underweight, have kidney or liver problems, or are taking multiple medications may need their dosages adjusted by their doctor. Overdosage Return to top Any medication taken in excess can have serious consequences. An overdose of side effects of high doses of prozac Prozac can be fatal. In addition, combining Prozac with certain side effects of high doses of prozac other drugs can cause symptoms of overdose. If you suspect an overdose, seek medical attention immediately. Common symptoms of Prozac overdose include: Nausea, rapid heartbeat, seizures, sleepiness, vomiting Other symptoms of Prozac overdose include: Coma, delirium, fainting, high fever, irregular heartbeat, low blood pressure, mania, rigid muscles, sweating, stupor Return to top Advertisement Health Centers: Woman's Health | Men's Health | Senior's Health | side effects of high doses of prozac Healthy Kids Sex and Reproduction | Pregnancy | Baby and You | DentalHealth Linking: HealthSquare welcomes sites interested in promoting Health and Wellness to freely link to our site. NOTICE: HealthSquare is solely to be used as an informational resource and should never be used to replace contact with your licensed healthcare provider. HealthSquare subscribes to the HONcode principles of the Health On the Net Foundation Advertisement Health side effects of high doses of prozac Centers Woman's Health Sex, Reproduction, and Birth Control Pregnancy Men's Health Baby and You Healthy Kids Privacy | About | Advertising | Copyright Advertisement Advertisement NOTICE: HealthSquare is solely to be used as an informational resource and should never be used to replace contact with your licensed healthcare provider. PHYSICIANS' DESK REFERENCE, PDR®, The PDR® Family Guide to Prescription Drugs, The PDR® Family Guide to Women's Health and Prescription Drugs and The PDR® Encyclopedia of Medical Care™ side effects of high doses of prozac are registered trademarks used herein under license. 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None of the contents of contained on this service may be reproduced, stored or transmitted in any form without prior written permission of Medical side effects of high doses of prozac Economics Company, Inc. 06/05/04 SIDE EFFECTS OF HIGH DOSES side effects of high doses of prozac OF PROZAC Side effects of high doses of side effects of high doses of prozac prozac Side Effects Of High Doses Of Prozac Orlistat works by blocking some of the fat normally digested by the intestine After opening the packet, the full dose must be administered within 15 minutes g Lowered LDL side effects of high doses of prozac cholesterol, the "bad" cholesterol, by 39-60% • side effects of high doses of prozac Drugs other than those listed here may also interact with montelukast , oxalate kidney stones, hyperoxaluria) These effects were maintained for over 2 years with continued PROPECIA therapy CELEBREX cannot be expected to substitute for corticosteroids or to treat corticosteroid insufficiency Before taking montelukast, tell your doctor if you side effects of high doses of prozac are taking rifampin (Rimactane, Rifadin) or phenobarbital (Luminal, Solfoton) Finasteride should NOT be used with children - If you have had an side effects of high doses of prozac allergic reaction to aspirin or other NSAIDs · insomnia If these effects persist or worsen, notify your doctor promptly Your symptoms may start to improve before the infection is completely treated What side effects of high doses of prozac is Atorvastatin? Take your next dose as soon as you remember • Montelukast can be taken with or without food · worsening respiratory symptoms PROPECIA is the brand name for finasteride, which acts to inhibit the conversion of the androgen (male hormone) testosterone into 5-alpha-dihydrotesterone (DHT) Do not increase your dose or take side effects of high doses of prozac it more often than prescribed - Boost side effects of high doses of prozac Sexual Performance • Losartan can be taken with or without food • Montelukast will not stop an asthma attack that has already begun g If a meal is occasionally missed or contains no fat, skip that dose of the medication If you are one of the many people who side effects of high doses of prozac take low-dose aspirin for the prevention of heart attack or stroke, you can still take CELEBREX Keep this and all medications out side effects of high doses of prozac of the side effects of high doses of prozac reach of children If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you Take this as directed In medical studies of people with high cholesterol, Atorvastatin, taken once a day, had the following side effects of high doses of prozac effects at doses of 10 to 80 mg: Lowered total cholesterol by 29-45% It may take up to 6 to 12 months for this medicine to work It is not side effects of high doses of prozac known whether Xenical is excreted into breast milk It was concluded side effects of high doses of prozac from these studies that side effects of high doses of prozac as long as PROPECIA therapy side effects of high doses of prozac is continued it will remain effective in facilitating hair regrowth Xenical should not be used if you have anorexia nervosa or bulemia-type eating disorders • Drugs other than those side effects of high doses of prozac listed here may also interact with montelukast Change positions slowly • Side effects other than those listed here may also occur Continue to take cephalexin and talk to your doctor if you experience Follow the Fosamax directions on your Fosamax prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand • side effects of high doses of prozac Take each dose side effects of high doses of prozac with a full glass (8 ounces) of water When less cholesterol is produced, the liver takes up more cholesterol from the bloodstream 0% of men taking this medicine · dizziness or headache; Shake the suspension well before measuring a dose Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products Finasteride should NOT be used with children If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you - Fuller & Harder Erections INCLUDE IN YOUR MEDICAL HISTORY/PERSONAL PROFILE : Consult your doctor before breast-feeding What are the effects of Atorvastatin tablets? Do not increase your dose or take this more often than directed Atorvastatin is a very effective medicine for lowering high LDL cholesterol—the main target of cholesterol-lowering therapy , acid reflux or GERD, ulcers, erosive esophagitis, Zollinger-Ellison syndrome) Tell your doctor of all over-the-counter and prescription medication you may take including: sedatives, tranquilizers, side effects of high doses of prozac sleeping pills, narcotic pain relievers, medication for depression and certain antihistamines (e · dizziness, or Lowered triglyceride levels by 19-37% side effects of high doses of prozac CELEBREX can be taken with or without food Discuss the risks side effects of high doses of prozac and benefits with your doctor The full effect is usually seen within 4 weeks and lasts as long as you continue taking it • Montelukast may also be used for purposes other than those listed side effects of high doses of prozac in this medication guide Regalis (Tadalafil) is known as Super Viagra because it acts quicker and lasts side effects of high doses of prozac much longer! Cialis is a brand new treatment for impotence that works just like Viagra, only it gives you faster results, has a higher success side effects of high doses of prozac rate, side effects of high doses of prozac lasts up to side effects of high doses of prozac 32 hours longer, and side effects of high doses of prozac causes fewer unpleasant side effects! Fosamax/Alendronate comes as a tablet to take by mouth Take this drug by mouth, generally three times daily during (or up to one hour after) each main side effects of high doses of prozac meal that contains fat • Montelukast is usually side effects of high doses of prozac taken in the evening Before taking any other medications, either prescription or over-the-counter, talk to your doctor or pharmacist Your doctor will prescribe the dose that is right side effects of high doses of prozac for you, which may be 10 mg to 80 mg Continue to take losartan and talk to your doctor if you experience - If you are pregnant or plan to become pregnant Take this as directed Take LEVITRA no more than once a day CELEBREX side effects of high doses of prozac is not a substitute for aspirin for heart attack or stroke prevention - Increase Stamina & Endurance This medicine can be taken with or without food Overall improvements were seen as side effects of high doses of prozac quickly as 3 months after starting the medicine Regalis (Tadalafil) is known as Super Viagra because it side effects of high doses of prozac acts quicker and lasts side effects of high doses of prozac much longer! Cialis is a brand side effects of high doses of prozac new treatment for impotence that works just like Viagra, only it gives side effects of high doses of prozac you faster side effects of high doses of prozac results, has a higher success rate, lasts up to 32 hours longer, and causes side effects of high doses of prozac fewer unpleasant side effects! It may be some time before you begin to notice effects side effects of high doses of prozac from this medication Fosamax/Alendronate should be taken once a day in the morning on an empty stomach Who should not take Atorvastatin tablets? • Montelukast will not stop an asthma attack that has already begun If you experience other bothersome side effects, talk to your health care provider Investigators have found that PROPECIA increases hair growth in over 80% of side effects of high doses of prozac men , side effects of high doses of prozac acid reflux or GERD, ulcers, erosive esophagitis, Zollinger-Ellison syndrome) · nasal irritation If you notice other effects not listed above, contact your doctor or pharmacist The manufacturer does not recommend use of Xenical during pregnancy Atorvastatin is a prescription drug side effects of high doses of prozac in one of side effects of high doses of prozac the newest classes of cholesterol-lowering medications, called statins LEVITRA provided first time success and reliable improvement of erection quality for many men The full effect on side effects of high doses of prozac weight may require four to six weeks 5 mg, 5 mg, 10 mg, and 20 mg tablets and is taken only when needed · dizziness, or Change positions slowly If a meal is occasionally missed or contains no fat, skip that dose of the medication This medication is known as a proton pump inhibitor (PPI) · severe nausea, vomiting, side effects of high doses of prozac or diarrhea; ROPECIA tablets are film coated; therefore women can safely handle the intact tablet side effects of high doses of prozac It may take up to 6 to side effects of high doses of prozac 12 months for this medicine to work Paxil works by helping to restore the balance of certain natural chemicals in the brain • The granules can be given either directly into the side effects of high doses of prozac mouth or mixed with a spoonful of cold or room temperature applesauce, mashed carrots, rice, or ice cream This medication may be taken with food side effects of high doses of prozac or immediately after meals to prevent stomach upset Continue to take montelukast and talk to your doctor if you experience Limit alcohol intake while taking this medication Take as directed, usually twice daily for 7 to 12 weeks christina ricci prozac nation nude - behavioral side effects of children on prozac - prozac and insomnia help - prozac survivors - prozac effects - does snorting prozac get you high - prozac estrogen replacement therapy - dogs and prozac - alcohol interact with prozac - prozac feline dosage - does alcohol interact with prozac - harmful effects of mixing prozac and alcohol - prozac truth - prozac medication - what are the sideeffects of prozac - prozac for sale - side effects of high doses of prozac prozac weight solution - prozac withdraw - what are the side effects of prozac - prozac nation the movie - side effects of high doses of prozac psychosis taking prozac side effects of high doses of prozac and narcotics side effects of high doses of prozac - taking prozac in morning or night - review prozac way life - prozac and dog dose - prozac drug interactions side effects of high doses of prozac - feeling worse on prozac - prozac makes gays act normal - side effects of quitting prozac - prozac weekly - coming off prozac - prozac cheap - prozac wellbutrin cylert together - lewis structure for prozac - combining prozac with remeron - prozac premature ejaculation - prozac and lithium - side effects of drug prozac - what is prozac - buy us prozac - dog prozac - canine prozac - sleepy on prozac - quitting prozac - prozac and pregnancy - prozac side effects of high doses of prozac during pregnancy - signs of prozac withdrawl - buy phentermine prozac - prozac seroquel - generic prozac - prozac and its side effects - generic vs prozac - prozac nation christina ricci nude - side effects of high doses of prozac - hand tremor prozac side effects of high doses of prozac side effect - zoloft vs prozac - prozac - prozac poop out - prozac on sleep - prozac sales - marijuana interactions prozac - prozac ocd - prozac not working - side effects of high doses of prozac alcohol interaction prozac - should prozac and abilify be taken together - buy generic prozac online - side effects of high doses of prozac prozac dangers - treating autism with prozac - equine prozac - what does prozac do - prozac psychosis - withdrawl symptoms of prozac - The Aftermath Of Prozac, Zoloft, Luvox, Fen-Phen, And Many Other Serotonergic Drugs SIGHTINGS The Aftermath Of Prozac, Zoloft, Luvox, Fen-Phen, & Many Other Serotonergic Drugs By side effects of high doses of prozac Dr. Ann Blake Tracy - Executive Director, International Coalition For Drug side effects of high doses of prozac Awareness www.drugawareness.org 5-6-00 Dr. Ann Blake Tracy, a PhD in Psychology and Health Sciences, has specialized for 10 years in adverse reactions to serotonergic medications. She is the executive director of the International Coalition for Drug Awareness (www.drugawareness.org) and author of the book PROZAC: PANACEA OR PANDORA? (800-280-0730) WARNING: IT SHOULD BE NOTED THAT A GRADUAL TAPERING OFF OF MEDICATIONS IS SAFEST WITHDRAWAL METHOD TO AVOID SERIOUS WITHDRAWAL EFFECTS (Often there is the terrible withdrawal associated with the SSRIs. Unless patients are side effects of high doses of prozac warned to come very slowly off these drugs by shaving minuscule amounts off their pills each day, as opposed to cutting them in half or taking a pill every other day, they can go into terrible withdrawal which is generally delayed several months. This withdrawal includes bouts of overwhelming depression, terrible insomnia and fatigue, and can include life-threatening physical effects, psychosis, or violent side effects of high doses of prozac outbursts.) Note: Keep in mind that these drugs are all serotonergic agents and clones or "copy cat" drugs side effects of high doses of prozac of Prozac - side effects of high doses of prozac the first SSRI antidepressant introduced to the market in America. Basically what applies to one, applies side effects of high doses of prozac to side effects of high doses of prozac the others. For instance we have more data out on Prozac because it has been around longer, but as the mode of action is the same for all of these meds the effects will be the same for the side effects of high doses of prozac other drugs on this list as it is for Prozac. If we are discussing side effects of high doses of prozac one drug, similar effects would be expected from any other company's version of the drug. In fact it would be more honest to give them the titles side effects of high doses of prozac of Prozac #1, Prozac #2, Prozac #3, etc. rather than the brand names they have been given, from the second clone, Zoloft, to the latest Prozac clone, Celexa. My concern is that each new SSRI introduced seems side effects of high doses of prozac to be a little stronger on serotonin reuptake and therefore potentially more dangerous. And the all too common practice of going from one SSRI to another blocks additional receptors and magnifies the harmful effects of side effects of high doses of prozac these medications. It is crucial to learn that according to medical research the theory behind this group of drugs is invalid. side effects of high doses of prozac Known as serotonin reuptake inhibitors. They are designed to block serotonin in the side effects of high doses of prozac brain, thereby increasing brain levels of this neurotransmitter. side effects of high doses of prozac Yet for three decades researchers have been intensely side effects of high doses of prozac interested in serotonin because LSD and PCP produce their psychedelic effects by mimicking serotonin. Elevated serotonin is found in: psychosis or side effects of high doses of prozac schizophrenia, mood disorders, organic brain disease, mental retardation, autism and Alzheimer's. While low levels of the metabolism of serotonin (which also produces high serotonin), are found in those with: depression, anxiety, side effects of high doses of prozac suicide, violence, arson, substance abuse, insomnia, violent nightmares, impulsive behavior, reckless driving, exhibitionism, hostility, argumentive behavior, etc. The drugs increase serotonin and decrease the metabolism of side effects of high doses of prozac serotonin leading to any and all of the above results. This information is extremely crucial for patients and physicians to learn as soon as possible. We have a high rate of use of these drugs nationwide. Raising serotonin and lowering the side effects of high doses of prozac metabolism of serotonin in such a large number of people can side effects of high doses of prozac produce very serious, widespread and long term problems for all of society. So why are we now in the 90's being told that increased serotonin is good for us? Is it because it is good for the pocketbooks of the manufacturers? One manufacturer is running full page newspaper and magazine ads and half hour TV infomercials to bring in over $7 million daily, while side effects of high doses of prozac on the other hand they side effects of high doses of prozac are settling Prozac suicide cases for huge amounts of money in exchange for side effects of high doses of prozac silence from victim's families on the details of those settlements. The silence in the court cases insures that the drug will be allowed to finish out its patent time, thus bringing in the highest possible profits for side effects of high doses of prozac the company. They know that with $7 million coming in daily, side effects of high doses of prozac they can afford to settle a large number of lawsuits and still come out "smelling like a rose" financially. Eli Lilly has been sued for Prozac related deaths in numerous state and federal side effects of high doses of prozac courts with most of these cases being settled or dismissed - many were dismissed due to the unethical manipulation of the Wesbecker verdict (see time line for details). We have witnessed no decrease in suicide, but increases in side effects of high doses of prozac murder/suicide, suicide, unwed pregnancies, domestic violence, manic-depression, MS, hypoglycemia, diabetes, bankruptcies, divorce, mothers (parents) killing children, road rage, school shootings, cancer, Chronic Fatigue Syndrome, and fibromyalgia since these serotonergic drugs have become so popular and side effects of high doses of prozac I relate it directly to the effects of these drugs. The death toll has continued to climb drastically since I wrote PROZAC: PANACEA OR PANDORA? Some of the cases you may be familiar side effects of high doses of prozac with are: Mr. and Mrs. Phil Hartman (Zoloft), Prozac was found in the van of Mark Barton, the Atlanta day trader, who recently killed his family and others in a shooting spree before taking his own life; Neal Furrow, in LA Jewish school shooting was reported to have been court ordered to be on Prozac along with several other medications; the Salt Lake Family History Library shooting, school shootings in Littleton, Colorado (Luvox), Atlanta, Georgia, Springfield, Oregon side effects of high doses of prozac (Prozac), and Caldwell, Idaho; another side effects of high doses of prozac boy in Pocatello, ID in 1998 who in seizure activity from Zoloft had a stand off at the school; 15 year old Chris Shanahan (Paxil) in Rigby, ID who out of the blue killed a woman; the shooting at the lottery in Connecticut side effects of high doses of prozac last spring by Matthew Beck side effects of high doses of prozac (Luvox) that left five dead in a murder/suicide; the New York City Subway bombing by Edward Leary (Prozac); little 10 year old Timmy (Prozac) in southern Florida; Nick Mansies (Paxil) in New Jersey who was convicted of killing a little boy who was selling cookies door to door; in Orange County, CA Dana Sue Gray (Paxil) who co-workers described as a very caring nurse killed several elderly people; Officer Stephen Christian (Prozac) one side effects of high doses of prozac of the finest officers on the Dallas Police force, who ran into a police side effects of high doses of prozac substation shooting at fellow side effects of high doses of prozac officers and was killed; 13 side effects of high doses of prozac year old Chris side effects of high doses of prozac Fetters (Prozac) in Iowa who killed her favorite aunt; David side effects of high doses of prozac Rothman (Prozac) killed two co-workers and himself at the Dept. of Agriculture in Ingelwood, CA; Williams Evans (Zoloft) shot one co-worker at the Ohio Bureau of Employment Services before shooting himself in Columbus, OH; Winatchee, WA where 43 people were wrongfully imprisoned in side effects of high doses of prozac a false accusation side effects of high doses of prozac of sexual abuse "witch hunt" side effects of high doses of prozac fury started by a child under the influence of Prozac and Paxil; Christopher Vasquez (Zoloft) killed Michael McMorrow in Central Park; Megan Hogg (Prozac) side effects of high doses of prozac duct taped the mouths and noses side effects of high doses of prozac of her three little girls and took a handful of pills; Vera Espinoza (Prozac) in side effects of high doses of prozac Randolph, VT shot her small son and daughter before shooting herself; an elderly man (Prozac) in Layton, UT axed his wife and daughter to death; Margaret Kastanis (Prozac) used a knife and hammer to kill her three children side effects of high doses of prozac before stabbing herself to death; an elderly man (Paxil) in Dallas, TX strangled his wife before shooting himself twice side effects of high doses of prozac in the side effects of high doses of prozac chest; Larramie Huntzinger (Zoloft) blacked out and ran his car into three young girls side effects of high doses of prozac killing two in Salt Lake City, UT; Mary Hinkelman (Prozac), a side effects of high doses of prozac nurse in Baroda, MI shot her two small daughters and her sister before shooting herself; Lisa Fox (Prozac) shot her small son and her dog before shooting herself in Brighton, MI; Debi Louselle (Zoloft) shot daughter and then herself in Salt Lake City, UT; a father in Wyoming shot his wife, daughter and baby grand-daughter then himself after only days on Paxil; a mother (Prozac) in Pleasant Grove, side effects of high doses of prozac UT killed her 17 year side effects of high doses of prozac old son with a sledge hammer while he slept before she attempted suicide by drinking draino; Larry Butzz, a superintendent of schools in Ames, IA shot his wife, son and daughter before shooting himself - many cases pending in court are not mentioned. This is only a handful of MANY, MANY more cases - there would not be room for anything else side effects of high doses of prozac if I continued listing the cases. A few additional famous victims: Princess Di (Prozac) and Dodi Fayed -via their driver Henri Paul (Prozac), Monica Lewinsky side effects of high doses of prozac (Prozac, Zoloft, Effexor, Serzone and Phen-Fen), Chris Farley (Prozac), Pres. Clinton's side effects of high doses of prozac ex-partner Jim Mc Dougal (Prozac), Abby Hoffman (Prozac), Del Shannon (Prozac), Danielle Steele's son (Prozac), INXS singer Michael Hutchence (Prozac), Sarah - Dutchess of York (Phen-Fen) The latest figures show Prozac has about 44,000 adverse reports side effects of high doses of prozac filed with the FDA. Out of those reports there are about 2500 deaths with the large majority of them linked to suicide or violence. The suicide statistics relating to women side effects of high doses of prozac are shocking. According to the CDC side effects of high doses of prozac there are about 30,000 suicides yearly in side effects of high doses of prozac the United States. Out of those about side effects of high doses of prozac 6,000 are women - a ratio of about 4.3 to 1, male to female. About twice as many women as men are treated for depression demonstrating that generally men are more than 8 times as lethal in their suicidal gestures as women. Women were known to use less lethal means until the SSRI side effects of high doses of prozac antidepressants hit the market. But on Prozac and Paxil, women committed 40% of the suicides - many were strikingly violent and side effects of high doses of prozac clearly leaving no means for rescue. (Remember that because Prozac was the first side effects of high doses of prozac of this group of side effects of high doses of prozac drugs its track record gives us a vision of what is to come with other serotonergic antidepressants, especially when they are so powerful in the reuptake of serotonin.) TIME LINE OF CRITICAL INFORMATION DISCOVERED SINCE THE BOOK: *NOTE: Any documents beginning with PZ are Lilly documents on Prozac side effects of high doses of prozac which have been ferreted out by attorneys and are now being used in lawsuits against the drug company. (Christian vs. Eli Lilly, by Vickery & Waldner, Houston, TX) - - Mid 1950's: Dr. Felix Sulman began his research on those who suffer from high serotonin levels because of an inability to metabolize serotonin. He found that serotonin is a stress neuro-hormone leading even rabbits, the most docile of creatures, to be aggressive. He coined the term "serotonin irritation syndrome." side effects of high doses of prozac He found that those who were unable to break down serotonin would have the levels increase. They "were in effect being poisoned by the serotonin produced by their own bodies, the irritation victims suffered from migraines, hot flashes, irritability, sleeplessness, pains around the side effects of high doses of prozac heart, difficulty in breathing, a worsening of bronchial side effects of high doses of prozac complaints, irrational tension and anxiety. . . horrifying nightmares. It also caused his volunteers to sleep badly - that is, always on the edge of consciousness so that they were not properly rested - and to wake after side effects of high doses of prozac only a few hours of sleep." (sleep apnea) He also found it caused pregnant women to abort. - - October, 1977: Slater, et.al., Inhibition of REM Sleep by Fluoxetine, a Specific Inhibitor of Serotonin Uptake, October 1977, at p. 385 - Prozac side effects of high doses of prozac was found to affect sleep habits, specifically to suppress deep side effects of high doses of prozac sleep, which side effects of high doses of prozac the scientists call REM (rapid eye movement) sleep in cats. By the fourth day of drug treatment the cats receiving the larger doses, which had been friendly for years, began to growl and hiss. . . side effects of high doses of prozac . After cessation of the drug treatment, the cats returned to their usual friendly behavior in a week or two; those on the higher doses recovering more slowly. - - 1977: [PZ 1298 1999] "A total of six dogs from the side effects of high doses of prozac high dose group were removed from treatment ... due to severe occurrences of either aggressive behavior, ataxia, or anorexia."] - - July 31, 1978: [PZ1061 1025-28, July 31, 1978] Human subjects began to be used by Lilly in controlled clinical trials. The first group of patients showed no improvement in their depression, but there were a "large number of reports of adverse reactions." The first human to receive Prozac experienced "dystonia resembling an extrapyramidal reaction" - side effects of high doses of prozac an uncontrollable, Parkinson-like shaking or trembling. - - July 23, 1979 [PZ 1297 969] The clinical studies in depression showed that "some patients have converted from side effects of high doses of prozac severe depression to agitation within side effects of high doses of prozac a few days; in one case the agitation was marked and the patient side effects of high doses of prozac had to be taken off drug. In future studies the use of benzodiazepines to control the agitation will be permitted." - - side effects of high doses of prozac August 3, 1979: The clinical trials excluded patients who had serious suicidal risk. [E.g. control #001519, IND Protocol No. 14, August 3, side effects of high doses of prozac 1979; PZ1135 695, July 2, 1986 memorandum of Dr. Wernicke]. - - December 17, 1984: side effects of high doses of prozac [PZ 65 449, report of Lilly to FDA] Lilly reported to the FDA that benzodiazepines and other sedatives were given with Prozac throughout the clinical trials. This was to help offset the stimulant effect of the drug. In a memorandum of Lilly scientist Charles Beasley [PZ 541 2007-08] issues of "agitation vs. sedation" and concomitant sedative medications side effects of high doses of prozac like benzodiazepines (to control the agitation) are discussed. Concerns are that agitation in a suicidal patient can induce suicide. - - March 3, 1986 Lilly controlled the flow of information to the FDA and decided that suicide data on Prozac should not be evaluated, "in the safety-update for the FDA the number of suicides and suicide attempts will not be especially evaluated." [PZ 879 1966, March 3, 1986 telex] - - September 12, 1986: German BGA very concerned with the risk of suicide and ultimately approved Prozac on the condition that physicians be warned of the risk of suicide and told side effects of high doses of prozac to consider using sedatives and side effects of high doses of prozac closely monitor patients. [PZ 878 1383, report of Lilly consultant Pohlmeier; PZ 2467 299, September 12, 1986] Lilly actually warned physicians in Germany and other countries that this measure "can be necessary" to minimize the risk of suicide, [PZ 1341 402, December 6, 1989 German warning; PZ 2469 490] - - February 7, 1990: In response to the Harvard study, Teicher, et al., Lilly's top scientist, Leigh Thompson, told his fellow executives that side effects of high doses of prozac "Lilly can go side effects of high doses of prozac down the tubes if we lose Prozac". [PZ 1941 827, February 7, 1990]. In the ensuing months Dr. Thompson spoke frequently with side effects of high doses of prozac his principal FDA regulator about the issue, once at side effects of high doses of prozac 6:15 in the morning. [PZ 391 side effects of high doses of prozac 1959, July 18, 1990]. Lilly later described side effects of high doses of prozac the man as "our defender". [PZ1941 2256, September side effects of high doses of prozac 12, 1990] - - May 29, side effects of high doses of prozac 1990, Lilly added "suicidal ideation" in side effects of high doses of prozac the section dealing with post-marketing reports. [PZ883 562, July 26, 1990 memorandum] - - September 14, 1990: Contrary to the advice of his staff, Dr. Thompson told the Eli Lilly Board of Directors that suicide and hostile acts were probably, caused by the patients' underlying disorders rather than Prozac. [PZ542 2101, September side effects of high doses of prozac 14, 1990; PZ4002 889, Board Minutes]. The staff was concerned because they knew that this side effects of high doses of prozac issue was never studied during the clinical trials. - - September 11, 1990: Note from Dr. Bruce Stadel, Chief of the Epidemiology Branch, attaching an analysis done by Dr. David Graham, side effects of high doses of prozac Section Chief within the Epidemiology Branch, of Lilly's July 17, 1990 submission to the FDA side effects of high doses of prozac on the Prozac/suicidality/violence issue. The following factors were (a) brought to the side effects of high doses of prozac attention of those in the higher echelons of the FDA, but (b) ignored, discounted or "trashed" by them: #1 Lilly's analysis improperly excluded 76 out of 97 suicides; as Dr. Stadel expressed it, "[i]t side effects of high doses of prozac is inappropriate in a safety analysis to exclude such a large proportion of case"; #2 Lilly admitted that its clinical trials "were not designed for the prospective evaluation of suicidality" and that "[i]n these trials, patients with current suicidal ideation were excluded"; #3 Lilly admitted that the HAMD-3 rating scale it used to assess side effects of high doses of prozac suicidality in clinical trials was inadequate; and that Lilly's statements about violence only demonstrated "how great under-reporting is" and that "[t]he actual data showed a higher percentage of treatment-emergent suicidality among fluoxetine (2.9% than tricyclic (0.8%) patients . . . [which percentage] side effects of high doses of prozac was similar to that reported by Teicher." - - July 1, 1992: A study lead by Dr. Lorne Brandes of the Manatoba Institute side effects of high doses of prozac of Cell Biology in side effects of high doses of prozac Winnipeg, Canada was published in CANCER RESEARCH linking the two most popular anti-depressants, Elavil and Prozac to cancer. side effects of high doses of prozac - - 1993(?): A side effects of high doses of prozac study side effects of high doses of prozac headed by Edward Domino showed LSD flashbacks and LSD reactions induced by Prozac. - - June 9, 1994: The New York Review of side effects of high doses of prozac Books article by Dr. Sherwin Nuland slams Peter Kramer for pushing Prozac in his book Listening side effects of high doses of prozac to Prozac. He pointed out that all docs side effects of high doses of prozac are taught in med school this little poem about serotonin: "This man was addicted to moanin', confusion, edema, and groanin', intestinal rushes, great tricolored blushes, and died from too much serotonin." He listed constriction of lungs and intestines, diarrhea, wheezing, flushing, mental confusion, tightening of bronchioles, and lessening conscious control over behavior from increases in serotonin. "Moreover, . . . it is still too early to arrive at side effects of high doses of prozac a side effects of high doses of prozac reliable estimate of possible dangers that may appear in the long term," side effects of high doses of prozac and 15% dropped out of the clinical trials on Prozac because of adverse reactions. He also discussed the similarity of serotonin to the psychedelics like LSD and PCP. - - side effects of high doses of prozac November, 1994: Krystal JH, Webb E, Cooney N, et al., "Specificity side effects of high doses of prozac of Ethanol-like Effects Elicited in Serotonergic side effects of high doses of prozac and Noradrenergic Mechanisms," ARCHIVES OF GENERAL PSYCHIATRY, Vol. 51, Issue 11, pgs 898-911, 1994 demonstrated that an increase in brain levels of either of two neurotransmitters, serotonin or noradrenalin, produces: #1 a craving for alcohol, #2 anger, #3 anxiety. They found this to be especially true for those who have a history of alcoholism. An increase serotonin in turn increases noradrenalin. Numerous reports have been side effects of high doses of prozac made by reformed side effects of high doses of prozac alcoholics who are being "driven" to alcohol again after being prescribed a serotonergic drug. And many other patients who had no side effects of high doses of prozac previous side effects of high doses of prozac history of alcoholism have continued side effects of high doses of prozac to side effects of high doses of prozac report an "overwhelming compulsion" to side effects of high doses of prozac drink while using these drugs. (A few personal accounts: #1 A young woman, a recovering alcoholic, reported that during the eight side effects of high doses of prozac month period she had been side effects of high doses of prozac using Prozac she found it necessary to attend AA meetings every day in order to fight off the strong compulsions to begin drinking again. #2 In the Southeastern United States a middle aged psychologist, also a recovering alcoholic, after being prescribed Prozac, found herself needing to attend AA meetings morning, noon, and night to keep from destroying the sobriety she had achieved. #3 A young father, who was Mormon and had never before in his life used alcohol, found himself drinking Ever Clear and exhibiting bizarre side effects of high doses of prozac as well as violent behavior, after being prescribed Prozac and Ritalin. #4 A young mother who had side effects of high doses of prozac never used alcohol before began drinking large amounts within weeks of being prescribed Prozac and quickly found herself committed to a mental institution due to the psychotic behavior that resulted. Added to her Prozac prescription were anti-psychotic meds and side effects of high doses of prozac electric shock treatments. She then began to experience seizures and was started on anti-seizure meds. #5 A concerned side effects of high doses of prozac neighbor reported her friend was drinking straight Vodka on a regular basis after being prescribed Zoloft. #6 A daughter reported her father, sober for 15 years, began drinking again on Prozac. - - December, 1994: Not guilty verdict on Wesbecker wrongful death suit against Lilly's Prozac. - - Treatment emergent suicidality with Prozac has been demonstrated to be two to three times higher than any other side effects of high doses of prozac anti-depressant. (Jick, et al., Antidepressants and Suicide) - - May, 1995: Judge John Potter who presided side effects of high doses of prozac over the Wesbecker case filed documents to demand that Lilly be forced to disclose the secret deal they made with the plaintiffs to withhold very damaging evidence in exchange for settlement. In his pleading to the court Potter side effects of high doses of prozac stated, "Lilly sought to buy not just the verdict, but the court's judgment as well." Potter accused Lilly of "giving the verdict the widest possible publicity" accompanied by the claim that Lilly had "proven in a court of law that Prozac was safe." Furious with Lilly's side effects of high doses of prozac attempt to turn his courtroom into an advertising agency for Prozac, he claims his motion reflects "the court's duty to protect the integrity of the judicial system." He side effects of high doses of prozac believes, as do prominent legal ethicists, that a full and open disclosure of the terms of the settlement is a necessary public safety issue. - - July, 1997: Mayo Clinic found that the increased serotonin, which produces blood clotting, was causing a gummy glossy substance to build up on heart valves. Dr. Heidi Connolly with the Divisions of Cardiovascular Diseases and Internal Medicine, who headed the study stated, side effects of high doses of prozac "We do know that fenfluramine and phentermine [Fen-Phen] alter the way the side effects of high doses of prozac brain chemical serotonin is metabolized, side effects of high doses of prozac and serotonin that circulates in the blood can side effects of high doses of prozac cause valve injury." Fenfluramine produces a rapid side effects of high doses of prozac release of serotonin, inhibits side effects of high doses of prozac serotonin reuptake, and may also have receptor agonist activity. The study's revelations should send a loud and very clear warning throughout the medical community side effects of high doses of prozac concerning all serotonergic medications - - August 25, 1997: Letter to Dr. Tracy, "I caught the last part of your presentation on Radio Station KEX, Portland, while flipping through the dial last night. I was flabbergasted to hear you speak of the horrible potential side effects from Prozac, which I have been taking for approximately side effects of high doses of prozac four years, particularly since I have been diagnosed recently with cardiomyalgia, severe artery disease, congestive heart failure and also fibromyalgia. (I was a very "well" person prior to taking the Prozac and am now exhausted all the time, with horrible aching joints and considerable pain and a massive heart problem.) side effects of high doses of prozac The adverse cardiovascular effects from Prozac, the one drug in this class of drugs out long enough to have somewhat of track record, are listed in the drug information sheet put out by the side effects of high doses of prozac manufacturer. The "frequent" effects side effects of high doses of prozac listed are hemorrhage and hypertension. The "infrequent" effects include very serious adverse effects: congestive heart failure, myocardial infarct, tachycardia, angina pectoris, arrhythmia, side effects of high doses of prozac hypotension, migraine syncope and vascular headache. - - September, 1997: Redux and Phen-Fen were pulled from the market. - - October 20, 1997: Dr. Candace Pert, Research side effects of high doses of prozac Professor at Georgetown University Medical Center, past head of the brain chemistry department at the National Institute of Health, and author of the new book, MOLECULES OF EMOTION, side effects of high doses of prozac sounded an alarm in TIME, October 20. She stated, "I am alarmed at the monster that Johns Hopkins neuroscientist Solomon Snyder and I created when we discovered the simple binding assay for drug receptors side effects of high doses of prozac 25 years ago. Prozac and other antidepressant serotonin-receptor-active compounds may also cause cardiovascular problems in some susceptible people after long-term use, which has become common practice despite the lack of safety studies." (emphasis added) As we are being side effects of high doses of prozac led to believe these drugs produce effects only in the brain, Dr. Pert accuses the medical profession of oversimplifying the action of these drugs and adds that "the public is being misinformed about the precision of these selective serotonin-uptake inhibitors." It is critical that both physicians and side effects of high doses of prozac patients be made aware of these adverse physical reactions. She points out that the medical profession not only oversimplifies the action of these drugs in the brain, but "ignores the body as if it exists merely to carry the head around!" And that, "these molecules of emotion regulate every aspect of our physiology." The body plays a very significant role in how we feel and side effects of high doses of prozac act the way we do. This fact can no longer be ignored. - - Serotonin and serotonin receptors exist throughout the body, as well as the brain, and every aspect of the body's side effects of high doses of prozac physiology is affected by side effects of high doses of prozac these serotonergic medications. In side effects of high doses of prozac fact approximately 90% of the side effects of high doses of prozac body's serotonin is produced in the intestinal tract. According to Dr. Michael Gershon of New York's Columbia Presbyterian, this is the reason why Prozac produces so many gastrointestinal side effects. - - March, 1998: Two new studies published - one that side effects of high doses of prozac shows Prozac so strongly inhibits one particular serotonin receptor that side effects of high doses of prozac this produces both obesity and seizures and the other discusses the blockage of muscle and neuronal nicotinic acetylcholine receptors indicating interactions between the serotonergic and cholinergic systems in the central side effects of high doses of prozac nervous system. - - April, 1998: Our next generation of guinea pigs - one month before a 15 year old on Prozac, Kip Kinkel, in Springfield OR killed his parents and two classmates the American Psychiatric Association and the side effects of high doses of prozac American Academy of Pediatric Psychiatrists asked the FDA to consider the serotonergic antidepressants for use in children as young as two and drugs for anxiety, side effects of high doses of prozac aggression and manic depression in babies only one month old! The use of Prozac among young children ages 6 - 12 side effects of high doses of prozac has increased an alarming 400% from 1995 (51.000 new prescriptions) to 1996 (203,000 new prescriptions). - - June, 1999: CLINICAL PSYCHIATRY NEWS reported that side effects of high doses of prozac Dr. Malcolm Bowers a psychiatrist at Yale has found that physicians are not paying enough attention to side effects of high doses of prozac patient factors that could make initiation of SSRIs dangerous. He found side effects of high doses of prozac that side effects of high doses of prozac "SSRI-induced psychosis side effects of high doses of prozac has accounted for 8% of all general hospital psychiatric admissions over a recent 14-month period." And "What is surprising is that this particular group of side effects is really underplayed." (The 8% figure represents over 150,000 SSRI induced psychotic breaks per year!!!!!!!) - - Warning: Children so often get coughs and colds, yet using a cough or cold medication with dextromethorphan could cause the serotonin syndrome, a very serious side effects of high doses of prozac and potentially fatal adverse side effects of high doses of prozac reaction and/or produce PCP reactions. - - Serotonin syndrome remains an often misdiagnosed or unrecognized fatal reaction due to the medical profession being so uninformed about this drug-induced disorder. - - Developing brains are far more vulnerable than adult brains and brain damage generally becomes more side effects of high doses of prozac apparent after the brain is fully developed, rather than immediately. Increases in cortisol produce brain damage while medical research shows that one single side effects of high doses of prozac 30mg dose of Prozac DOUBLES side effects of high doses of prozac the level of cortisol. This drastic increase in cortisol causes a multitude of serious physical side effects of high doses of prozac reactions including impairment of linear growth, as well as impairing the development side effects of high doses of prozac and regeneration of side effects of high doses of prozac the liver, kidneys, muscles, etc. In light of side effects of high doses of prozac so many unspeakable tragedies, I have grown weary of all the silly philosophical discussions we have heard since Kramer's LISTENING TO PROZAC came out. Patients are dying or having their health destroyed mentally as well as physically (when do we begin to discuss the very serious physical side effects associated with high levels of serotonin?). These patients and their families are frantically searching for answers while side effects of high doses of prozac this research sits right under our noses and could easily be made available to them. The widespread use of Prozac and its clones is not a statement of either their safety or their effectiveness. It is a statement about the effectiveness of an infinite marketing budget and incredible advertising campaign! These drugs have very serious physical side effects, as well as side effects of high doses of prozac dangerous psychiatric side effects. To prevent further tragedy this medical research must be acknowledged and addressed in headline news without delay rather than remain buried in seldom read medical research documents as has been the case in the past with other mind- altering medications, once thought to be safe, which were subsequently side effects of high doses of prozac prohibited by law, ie. LSD, PCP, cocaine, etc.. Oct. 1998 note from a side effects of high doses of prozac British nurse: "I started having bad reactions . . . Oct '96 I found Prozac to be causing joint and muscle pain itself . . . signs of Cushing's Syndrome. . . I was very pro-Prozac until last October and wouldn't have listened to anything said against it until I got problems (thought it was saving my life, while all the time it was insidiously and slowly killing me!) When I first heard about your book on the Internet I was interested but quite sceptical. However, side effects of high doses of prozac since reading it and having suffered so many problems with Prozac, I have come to the conclusion that the book is brilliant, and a life-line as far side effects of high doses of prozac as I am concerned. I tried to fault the research and reasoning, but could not and still can't. I would like to extend my thanks to you for your heroic stance on this enormously important side effects of high doses of prozac issue. I have tremendous respect and admiration for your hard work, determination and courage in side effects of high doses of prozac pursuing this subject so vigorously, against so much powerful opposition for the benefit of people like me. Your integrity puts many, if not most doctors and psychiatrists to shame. It is reassuring to find that there are a few people who are prepared to fight for the truth for the side effects of high doses of prozac benefit of side effects of high doses of prozac mankind." "PROZAC: PANACEA side effects of high doses of prozac OR PANDORA? is an incredible compilation of side effects of high doses of prozac medical data that will lay the groundwork side effects of high doses of prozac to educate other professionals and the general public about the new SSRI antidepressants - Prozac, Zoloft, Paxil, Luvox, Effexor and Serzone." . . . Jeff Wise, side effects of high doses of prozac psychologist, Salt Lake County Drug and Alcohol Abuse "In 15 side effects of high doses of prozac years of reading books on drugs I have never read a book with more information or so well side effects of high doses of prozac documented as PROZAC: PANACEA OR PANDORA? . . . Dr. Kevin Millet, Bountiful, UT "As I lecture to physicians nationwide on the medical use of psychoactive drugs PROZAC: PANACEA OR PANDORA? always accompanies me in my brief case. . . . side effects of high doses of prozac Dr. Bruce Woolley, neuropsychopharmacologist, Brigham Young Univ. "I found PROZAC: PANACEA OR side effects of high doses of prozac PANDORA? fascinating reading and the most complete analysis of the various factors pertaining to the Prozac controversy." . . . Attorney Donald Sokol, Susanville, CA "PROZAC: PANACEA OR PANDORA? literally saved my life, and if I'd known about it a year earlier, could have saved me untold grief and agony as side effects of high doses of prozac well. It is the only collated, comprehensive source I know of for this information , . . side effects of high doses of prozac . this book described everything that had happened to me in great detail, gave scientific reasons why it happened, backed it all up with solid research, included testimonials from hundreds of others in the same situation, it immaculately details, explains, and refers side effects of high doses of prozac one side effects of high doses of prozac to side effects of high doses of prozac the latest research on a whole hornet's nest of 'atypical' side-and/or after-effects from the use of these antidepressants. It also contains information on how to reduce the severity of problems encountered while starting on or going off these meds. . . . Nick Jameson, Prozac patient "Magnificent! This text is a monument to Ann Tracy's tenacity and love for her fellow human beings." . . . Dr. Paul Kennedy, N.J. "PROZAC: PANACEA OR PANDORA? has not left one question about these drugs unanswered! Ann Tracy has covered side effects of high doses of prozac them all." . . . side effects of high doses of prozac Margaret McCaffery, N.Y. (lost side effects of high doses of prozac her daughter, a neurosurgeon, in a side effects of high doses of prozac Prozac suicide) "The work Dr. Ann Blake Tracy is doing side effects of high doses of prozac is very important and she is truly a heroine." . side effects of high doses of prozac . . Dr. Candace Pert, Washington, DC, one of the two developers of the serotonin binding process which made possible the development of the serotonergic drugs, side effects of high doses of prozac (Dr. Pert has boldly side effects of high doses of prozac stated, speaking of these serotonergic medications, "I am side effects of high doses of prozac alarmed at the monsters I created!" ORDER PHONE: 1-800-280-0730 WEB ADDRESS: members.aol.com/atracyphd & www.drugawareness.org ORDER ADDRESS: Cassia Publications, PO Box 1044, West Jordan, UT 84084 PRODUCTS: (All prices in US funds<<<) ( Postage and handling: $4 in US, side effects of high doses of prozac $8 in Canada & Western Europe, and $10 elsewhere - per book - or side effects of high doses of prozac for any 6 tapes ordered without a book side effects of high doses of prozac - no charge for postage on tapes ordered with a book.) Book: PROZAC: PANACEA OR PANDORA? ($19.95) Audio Tapes: "Help! I Can't Get Off My Antidepressants! (1 1/2 hr side effects of high doses of prozac - $9.95); BYU Lecture (Christian - LDS; 45 min - $4.95); Dr. Tracy's favorite radio shows: Interview with David and Fawn Christopher (1994, Very informative - health oriented, 1 hr - $6.95), Art Bell Show (Sep. 1999, 4 hours, set of four tapes packed with information - $29.95), Interview with Frosty Fowler (1997, Christian oriented, side effects of high doses of prozac 1 hr - $6.95); Liberty Radio interview (1999, side effects of high doses of prozac politically oriented, 1 hr $6.95) & more to side effects of high doses of prozac follow. SIGHTINGS HOMEPAGE http://www.sightings.com This Site Served by TheHostPros Drug Overdosing: How To Avoid Medication Side Effects: Online Reference For Health Concerns translation by SYSTRAN MEMBERSHIP PRODUCTS MAGAZINE HEALTH CONCERNS NEWS ABOUT US LOGIN PROFILE FAVORITES ORDER HISTORY VIEW CART CHECKOUT Health Concerns Selector Select Health Concern Acetaminophen (tylenol) Poisoning: Acute... Acne Adrenal Disease Age-associated Mental Impairment (cognit... Alcohol Induced Hangover: Prevention Allergies Alzheimer's Disease Amnesia Amyotrophic Lateral Sclerosis (als) Anemia-thrombocytopenia-leukopenia Anesthesia And Surgical Precautions Anxiety And Stress Arrhythmia (cardiac) Arthritis Asthma Atherosclerosis Attention Deficit Disorder (add) Autism Autoimmune Diseases Avoiding Vitamin - A side effects of high doses of prozac Toxicity Bacterial Infections Balding Bell's Palsy Bladder Conditions Breast Cancer Bursitis Cancer - Overview Cancer Adjuvant Treatment Cancer Chemotherapy Cancer Clinics Cancer Gene Therapy Cancer Prevention Cancer Radiation Therapy Cancer Supplements Cancer Surgery Cancer Treatment: The Critical Factors Cancer Vaccines Candida (fungal, Yeast) Infections Cardiovascular Disease: Comprehensive A... Cardiovascular Disease: Overview Carpal Tunnel Syndrome Catabolic Wasting Cataract Cerebral Vascular Disease Cervical Dysplasia Cholesterol Reduction Chronic Fatigue Syndrome (cfs) Cirrhosis Colitis (ulcerative) Colorectal Cancer Common Cold Congestive side effects of high doses of prozac Heart Failure And Cardiomyopathy Constipation Crohn's Disease Deafness Depression Dhea Replacement Diabetes Digestive Disorders Down Syndrome Emphysema And Chronic Obstructive Pulmon... Epilepsy Esophageal Reflux Estrogen Replacement Therapy Exercise Enhancement And Risk Avoidance Fasting And Calorie Restriction Female Hormone Modulation Therapy Fibrocystic Breast Disease Fibromyalgia Flu (influenza Virus) Gingivitis Glaucoma Gulf War Syndrome Hearing side effects of high doses of prozac Loss Heavy Metal Toxicity Hemochromatosis Hepatitis side effects of high doses of prozac B Hepatitis C Herpes Viruses And Associated Diseases Hiv (immune Deficiency) Treatment Homocysteine Hypertension (high Blood Pressure) Hypoglycemia Immune Enhancement Inflammation (chronic) Influenza Virus (flu) Insomnia Irritable Bowel Syndrome Jet Lag Kidney side effects of high doses of prozac Disease Leukemia And Lymphomas side effects of high doses of prozac (hodgkin\'s And N... Liver Cirrhosis Liver Degenerative Disease Lupus Macular Degeneration (dry And Wet) Male Hormone Modulation Therapy Medical Testing Protocols Meningitis (viral) Menopause Migraine Multiple Sclerosis Muscle Building Muscular Dystrophy Myasthenia Gravis Myofascial Syndromes Nails Neuropathy Obesity Obsessive Compulsive Disorder Osteoporosis Pain Pancreatic Cancer Parathyroid (hyperparathyroidism) Parkinson's Disease Phenylalanine And Tyrosine Dosing And Pr... Phobias Polymyalgia Rheumatica Pregnenolone Precautions Premenstrual Syndrome And Menstrual Irre... Prevention Protocols Prostate Cancer: Overview Prostate Enlargement (benign Prostatic H... Pulmonary Insufficiencies Raynaud's Syndrome Retinopathy Scleroderma Seasonal Affective side effects of high doses of prozac Disorder (sad) Shingles And Postherpetic Neuralgia Sjogren's Syndrome Skin Aging Stress Stroke (hemorrhagic) Stroke (ischemic, Thrombotic, Embolic, A... Surgical side effects of high doses of prozac Precautions Thrombosis Prevention Thyroid Deficiency Tinnitus Trauma Urinary Tract Infections Uterine Fibroids Valvular Insufficiency/heart Valve Defects Vertigo Viral Meningitis Why Pharmaceutical Grade Supplements Are... Wound Healing (surgical Wounds, Trauma, ... Yeast Infections Page: 1 | 2 | 3 | 4 | 5 References | Disclaimer | Abstracts | Print Version Drug Overdosing: How to Avoid Medication Side Effects Updated: 7/08/2004 What Makes side effects of high doses of prozac Prescription Drugs So Dangerous Saving Lives Medication Side Effects Drug side effects are the fourth leading cause of death in the United States. According to an side effects of high doses of prozac article side effects of high doses of prozac published in the Journal of side effects of high doses of prozac the American Medical Association (JAMA) (Lazarou et al. 1998), about 106,000 side effects of high doses of prozac Americans die and 2,000,000 suffer from severe reactions every year from drugs prescribed in hospitals. The information presented in this protocol was written to enable you to reduce your risk side effects of high doses of prozac of adverse drug reactions, while saving significant dollars on the cost of your prescription medications. In addition, it will provide you with a greater sense of control over your future good health and help you to interact more confidently with side effects of high doses of prozac your physician. The statistics mentioned side effects of high doses of prozac above understate the true magnitude of the problem, since people often die from adverse drug reactions outside the hospital. There are also many side effects of high doses of prozac deaths that occur in hospitals caused by drugs prescribed outside the hospital. For example, some prescription drugs deplete calcium from bones, which causes elderly people to suffer fractures, which leads to their hospitalization. In the hospital, these people often develop pneumonia, vascular blood clots, sepsis, or some other illness that kills them. The death certificate may list "pneumonia" as the cause of death, but it was the inappropriate prescribing of the bone-depleting drug in the first place that caused the fracture, which necessitated the hospital confinement that led to pneumonia. An examination of the data beyond that recorded on death certificates reveals a shocking number of deaths related to inappropriate drug prescribing. Even when a drug like Rezulin (Sparano et al. 1998) was withdrawn because too many people were dying from liver failure (Watkins et al. 1998; Fukano et al. 2000), it was estimated that only one out of ten deaths caused by Rezulin was ever attributed to the drug (LA Times 2000). WHAT MAKES PRESCRIPTION DRUGS SO DANGEROUS? Too Much Prozac Epidemic of Overdosing All drugs have the potential to cause side effects by themselves, or through interaction with other drugs. This is one side effects of high doses of prozac reason why more people are side effects of high doses of prozac turning to natural therapies that have proven track records of safety. In order for pharmaceutical companies to earn a profit, they must side effects of high doses of prozac develop drugs that are potent enough to patent and can be approved by the FDA. To gain FDA approval, these drugs must demonstrate an acceptable safety profile. However, the safe dose of potent drugs can vary considerably among individuals. What is safe side effects of high doses of prozac for some people can be a lethal overdose for others. Yet doctors and drug companies usually recommend the same dose for everyone, even though lower doses of many prescription side effects of high doses of prozac drugs can achieve the same beneficial effects, while dramatically reducing side effect risk and the cost of the medications. Consider the cholesterol-lowering drug Zocor, for example. The recommended starting dose is 20 mg, which has been shown to lower side effects of high doses of prozac LDL cholesterol by an average of 38%. Scientific studies show, however, that 5 to 10 mg of Zocor works almost as well as 20 mg. side effects of high doses of prozac This lower dose could reduce the risk of side effects by as much as fourfold. If your LDL-cholesterol level is 130 (mg/dL) and your objective is to reduce it to under 100, just 5 mg a day of Zocor should accomplish this. Yet, the typical starting dose of side effects of high doses of prozac Zocor is 20 mg, and some doctors even start as high as 40 mg. . . eight times higher than the dose needed by many people! New studies indicate that side effects (especially muscle aches) side effects of high doses of prozac from statin drugs such as Zocor are more common than originally thought. When a person is prescribed 20 mg of Zocor, and encounters toxic side effects, the patient often abandons the drug. Yet, if side effects of high doses of prozac only 5 mg of Zocor were taken, the odds of encountering side effects would be reduced and the therapeutic target side effects of high doses of prozac (LDL-cholesterol under 100) might be easily side effects of high doses of prozac achieved. It's not just Zocor that is often overdosed. The number one statin drug sold in the United States is Lipitor, which is typically prescribed in doses of 10 mg and higher. There are studies, however, showing that as side effects of high doses of prozac little as 2.5 mg a day side effects of high doses of prozac is effective for side effects of high doses of prozac many people. If you are a statin drug user, have your blood tested to make sure your total cholesterol is not below 180 side effects of high doses of prozac mg/dL. Cholesterol levels below 180 (mg/dL) can increase side effects of high doses of prozac your risk of cerebral hemorrhage and other lethal diseases. Scientific studies show that the optimal total cholesterol range is 180-220, while LDL-cholesterol should be under 100 and beneficial HDL-cholesterol side effects of high doses of prozac over 50. Some statin drug users drop their total side effects of high doses of prozac cholesterol below 150. If these people had taken a lower dose of the drug, they would side effects of high doses of prozac probably side effects of high doses of prozac have adequately lowered their cholesterol levels, reduced their toxicity risk, and saved side effects of high doses of prozac a good deal of money. (See below on how to save money side effects of high doses of prozac on certain side effects of high doses of prozac prescription medications.) Too Much Prozac Prozac has side effects of high doses of prozac received considerable media attention for allegedly causing serious psychological disturbances. Attorneys have blamed Prozac for all kinds of criminal behaviors, and anecdotal reports abound about the side effects of high doses of prozac adverse effects some people experience on the standard (20 side effects of high doses of prozac mg) daily dose of this popular antidepressant. When Prozac was introduced, side effects of high doses of prozac it came only in 20-mg capsules, and all patients were started side effects of high doses of prozac at this dose. While Prozac helped most people, it caused serious side effects in others. Among the side effects caused by Prozac are side effects of high doses of prozac headache, nausea, irritability, sexual dysfunction (impaired orgasm, reduced libido), low energy, dry mouth, tremor, anxiety, and insomnia. A study published before Prozac was approved showed that a daily dose of 5 mg of Prozac side effects of high doses of prozac helped 54% of patients, while 20 mg side effects of high doses of prozac helped 64%. In other words, administering four times side effects of high doses of prozac the 5-mg dose only side effects of high doses of prozac helped 10% more people! Some doctors have found that lower doses of Prozac produce antidepressant benefits without causing side effects, yet the Physician's Desk Reference (PDR) and the drug's package insert side effects of high doses of prozac still recommend 20 mg as a starting dose. While overdosing on Prozac can cause serious psychological side effects, other antidepressants like Elavil can be lethal when taken side effects of high doses of prozac in too high doses. The PDR still advises an initial dose of 75 mg for Elavil (amitriptyline) followed by gradually higher doses. Yet 10 to 25 mg of Elavil is enough to treat mild side effects of high doses of prozac depression or pain syndromes. Too much Elavil can cause irreversible AV node block in side effects of high doses of prozac the heart, leading to fatal arrhythmia. Antidepressant drugs are often prescribed in higher-than-needed doses, side effects of high doses of prozac and the ensuing side effects cause many patients to abandon them altogether. An Epidemic of Overdosing Later in this chapter, you will side effects of high doses of prozac see how drug companies, physicians, and the FDA are all culpable in overdosing Americans with dangerous drugs. The chapter also explains the toxic mechanisms involved when too much of a drug is consumed, along with newly identified side effects of popular drugs. Of practical value are charts showing lower doses of the most popular prescription drugs, how to determine if you should start off at a lower dose, and how to avoid lethal drug interactions. This chapter exposes today's flawed system side effects of high doses of prozac of drug regulation. Prominent scientists accuse the FDA of failing to protect the American consumer against the drug companies. side effects of high doses of prozac The FDA claims it is protecting Americans against side effects of high doses of prozac dangerous drugs, yet the statistics show an epidemic of drug-induced injury and death. Too many consumers unknowingly overdose on their prescription drugs. When unpleasant side effects develop, side effects of high doses of prozac people often stop side effects of high doses of prozac taking the drug completely, even though a lower dose might be safe and effective. More than 100,000 Americans die every year from prescription drug side effects. In many cases, the drug-induced side effects of high doses of prozac death could have been avoided if a lower dose had been used. side effects of high doses of prozac SAVING LIVES Alternate Day Rather than Daily Dosing Dividing Doses Chronic overdosing of prescription drugs is one of the greatest health hazards Americans face. How can the medical establishment ignore something so obvious? Unfortunately, obvious ways of improving patient care side effects of high doses of prozac are routinely overlooked by medical professionals. Today's leading causes of disability side effects of high doses of prozac and death are ignorance and apathy in applying proven scientific methods of side effects of high doses of prozac preventing and treating disease. The information presented in this chapter will enable you to save hundreds of dollars a year on prescription drugs, while reducing your risk of debilitating or lethal side effects. Save Money With Alternate Day Rather than Daily Dosing Some drugs you are taking every day may work as well side effects of high doses of prozac if you take them every other day. In a study published in the American Heart Journal (Matalka et al. 2002), a comparison was done using the cholesterol-lowering drug Lipitor every day or every other (alternate) day. The findings showed that alternate-day dosing was comparable to dosing every day. The patients were started at 10 mg and their dose increased to 20 mg if needed. The every day dosing schedule required a mean of 12 mg/day of Lipitor to sufficiently lower cholesterol, whereas the alternate day group only required a mean 9 mg/day to achieve similar effects. The doctors concluded the study abstract by stating: "these results suggest that the alternate-day administration of atorvastatin (Lipitor) can produce a reduction in LDL-C comparable to that of daily side effects of high doses of prozac administration in patients with hypercholesterolemia, and yet provide some cost savings." What was side effects of high doses of prozac not revealed in this study was side effects of high doses of prozac the enormous amount of the cost savings. Life Extension has calculated the side effects of high doses of prozac exact amount one could save by switching to alternate-day dosing. Here are the numbers: The cost of taking 10 mg of Lipitor every day is about $60.00 a month. The cost of taking side effects of high doses of prozac 10 side effects of high doses of prozac mg of Lipitor every other day is only $30.00 a month. If 20 mg of Lipitor is needed every other day, the cost of 15 20-mg tablets comes out to about side effects of high doses of prozac $44.00 a month. Armed with this knowledge, the Lipitor consumer can save 50% ($30.00 each month) if they find they need only 10 mg of Lipitor every other day. If 20 mg of Lipitor is needed every other day, the consumer saves 26% ($16.00 each month). Anyone contemplating changing their dosing schedule of any drug should notify their physician and verify that the changed dose is working. In the case of Lipitor, one would want to check LDL, HDL, C-reactive protein and total cholesterol blood levels within 45 days of changing the dose. While "statin" side effects of high doses of prozac drugs like Lipitor are taken primarily side effects of high doses of prozac to lower cholesterol, side effects of high doses of prozac a side benefit is that they also lower the more dangerous side effects of high doses of prozac C-reactive protein. New studies confirm that C-reactive protein is a greater risk factor for heart attack and stroke side effects of high doses of prozac than is cholesterol. Many drugs side effects of high doses of prozac (such as anti-hypertensives) absolutely have to be taken every day or even several times throughout the day. Alternate-day dosing should not be attempted with any medication without physician approval. Save Money By Dividing Doses Many prescription drugs do not come in the lower doses that are optimal for many patients. In these cases, the tablets have to be split or capsules opened in order to obtain the desired dose. side effects of high doses of prozac While this is somewhat inconvenient, the cost savings can be substantial. Zocor side effects of high doses of prozac is one drug that comes in a wide range of doses. Here are the typical prices in the United States for 100 side effects of high doses of prozac tablets of each available dose of Zocor: 5 mg $171.87 10 mg $221.78 20 mg $371.00 40 side effects of high doses of prozac mg $390.00 80 mg $345.00 For the many Zocor users who need only 5 mg a day (instead of 20 side effects of high doses of prozac mg), the savings are 53% if one switches from the 20-mg dose to the 5-mg dose. For those who use a pill-splitter to break 20-mg tablets into four doses, the savings are 75%. Information about pill splitting devices appears later in this chapter. It is interesting to note that in today's upside-down drug pricing environment, 80-mg Zocor tablets sometimes cost less than 40-mg tablets. If you don't want to pay artificially inflated prices for prescription drugs, side effects of high doses of prozac you can order from Internet pharmacies in Canada. A bottle of 100 20-mg Zocor tablets side effects of high doses of prozac that costs $371.00 in the United States costs only $192.12 in Canada, a 48% savings. A bottle containing 100 5-mg tablets of Zocor costs $171.87 in the United States, but only $119.00 in Canada, side effects of high doses of prozac a 30% savings. That means if you buy 20-mg Zocor tablets in Canada and split them into four doses (5 mg each), you can save 86%. Not everyone can get by with only 5 mg a day of Zocor, but as shown in this chapter, many individuals are overdosing on statin and other drugs and can obtain better results by reducing their daily dose. MEDICATIONS SIDE EFFECTS: WHY THEY OCCUR AND HOW TO PREVENT THEM by Jay Cohen, M.D. Medications Side Effects Listening to Prozac Drugs for Cholesterol And C-Reactive Protein Drugs side effects of high doses of prozac Fof High Blood Pressure Anti-Inflammatory Drugs Other Drugs Exceptions Problems with The Medical-Pharmaceutical Complex A Right To Be Informed MEDICATIONS SIDE EFFECTS Avoiding Side Effects Individual Variation Prescription drugs help millions of people. Still, most people don't like taking drugs, although many of us ultimately need to. This section discusses how you can get the treatment you need while minimizing the risks. Mainstream medicine's record on preventing medication side effects is poor. A 1998 article in the Journal of the American Medical Association side effects of high doses of prozac (JAMA) defined the side effects of high doses of prozac scope of the problem: 106,000 deaths and 2,000,000 side effects of high doses of prozac severe reactions side effects of high doses of prozac from medications annually in U.S. hospitals, making side effects the fourth leading cause of death side effects of high doses of prozac in America (Lazarou et al. 1998). These numbers aren't new. The side effect problem has continued for decades and persists unrecognized side effects of high doses of prozac by many doctors and side effects of high doses of prozac authorities. But patients understand. Patients' first concern about medications is safety. They know intuitively that, as a side effects of high doses of prozac leading drug reference states, "Any drug, no matter how trivial its therapeutic actions, has the potential to side effects of high doses of prozac do harm" (Gilman et al. 1990). How can you maximize safety while getting the treatment you side effects of high doses of prozac need? There are ways that are in accordance with scientific principles and side effects of high doses of prozac proven by medical studies, side effects of high doses of prozac yet side effects of high doses of prozac routinely ignored by drug companies, side effects of high doses of prozac the FDA, and doctors. The First Key: Avoiding Side Effects Side effects occur because most drugs aren't specific in their actions. We may call a drug an "anti-inflammatory" or "antidepressant," but medications don't just go to side effects of high doses of prozac the cells involved in these problems. They go to most of the cells of our bodies, which can provoke undesirable effects. Thus, side effects of high doses of prozac an anti-inflammatory may reduce your joint pain, side effects of high doses of prozac but it may also cause stomach bleeding, kidney side effects of high doses of prozac failure, or anxiety. An antidepressant can improve mood but can also cause insomnia, nausea, weight side effects of high doses of prozac gain, or diminished sex drive. side effects of high doses of prozac Most side effects of high doses of prozac of these unintended effects--side effects--are dose-related. side effects of high doses of prozac You see the same phenomenon every day with alcohol and coffee. In moderate amounts, they side effects of high doses of prozac cause side effects of high doses of prozac few problems. But at excessive doses, coffee causes edginess and insomnia, and alcohol impairs thinking and coordination. The same is true with medications. Indeed, in the 1998 JAMA study cited above, side effects of high doses of prozac 76.2% of all side effects were dose-related. Melmon and Morrelli's Clinical Pharmacology places the number at 75% to side effects of high doses of prozac 85% (Melmon et al. 1993). The number may be higher, side effects of high doses of prozac because many drug interactions are also dose-related. When people take multiple drugs, higher doses cause more adverse interactions than lower doses. Whatever the actual number, the first key to avoiding side effects is this: Most side effects are dose-related. Hence, the problem isn't the drug itself, but a dose that's too strong for you. Thus, the best way to avoid side effects is to use the lowest dose that works. Excessive dosing merely increases risks. Home | Membership | Products | Magazine | Health Concerns | side effects of high doses of prozac News About Us | Legal Notices side effects of high doses of prozac | Privacy Policy | Site Map All Contents Copyright © 1995-2005 Life Extension Foundation All rights reserved. Drug Overdosing: How To side effects of high doses of prozac Avoid Medication Side Effects - Page side effects of high doses of prozac 2 Of 5: Online Reference For Health Concerns translation by SYSTRAN MEMBERSHIP PRODUCTS MAGAZINE HEALTH CONCERNS NEWS ABOUT US LOGIN PROFILE FAVORITES ORDER HISTORY VIEW CART CHECKOUT Health Concerns Selector Select Health Concern Acetaminophen (tylenol) Poisoning: Acute... Acne Adrenal Disease Age-associated Mental Impairment (cognit... Alcohol Induced Hangover: Prevention Allergies Alzheimer's Disease Amnesia Amyotrophic Lateral Sclerosis (als) Anemia-thrombocytopenia-leukopenia Anesthesia And Surgical Precautions Anxiety And Stress Arrhythmia (cardiac) Arthritis Asthma Atherosclerosis Attention Deficit Disorder (add) Autism Autoimmune Diseases Avoiding Vitamin - A Toxicity Bacterial Infections Balding Bell's Palsy Bladder Conditions Breast side effects of high doses of prozac Cancer Bursitis Cancer - Overview Cancer side effects of high doses of prozac Adjuvant Treatment Cancer Chemotherapy Cancer Clinics Cancer side effects of high doses of prozac Gene Therapy Cancer side effects of high doses of prozac Prevention Cancer Radiation Therapy Cancer Supplements Cancer Surgery Cancer Treatment: The Critical Factors Cancer Vaccines Candida (fungal, Yeast) Infections Cardiovascular Disease: Comprehensive A... Cardiovascular Disease: Overview Carpal Tunnel Syndrome Catabolic Wasting Cataract Cerebral Vascular Disease Cervical Dysplasia Cholesterol Reduction Chronic Fatigue side effects of high doses of prozac Syndrome (cfs) Cirrhosis Colitis (ulcerative) Colorectal Cancer Common Cold Congestive Heart Failure And Cardiomyopathy Constipation Crohn's Disease Deafness Depression Dhea Replacement Diabetes Digestive Disorders Down Syndrome Emphysema And Chronic side effects of high doses of prozac Obstructive Pulmon... Epilepsy Esophageal Reflux Estrogen Replacement Therapy Exercise Enhancement And Risk Avoidance Fasting And Calorie Restriction Female Hormone Modulation Therapy Fibrocystic Breast Disease Fibromyalgia Flu (influenza Virus) Gingivitis Glaucoma Gulf side effects of high doses of prozac War Syndrome Hearing Loss Heavy side effects of high doses of prozac Metal Toxicity Hemochromatosis Hepatitis B Hepatitis C Herpes Viruses And Associated Diseases Hiv (immune Deficiency) Treatment Homocysteine Hypertension (high Blood side effects of high doses of prozac Pressure) Hypoglycemia Immune Enhancement Inflammation (chronic) Influenza Virus (flu) Insomnia Irritable Bowel Syndrome Jet Lag Kidney Disease Leukemia And Lymphomas (hodgkin\'s And N... Liver Cirrhosis Liver Degenerative Disease Lupus Macular Degeneration (dry And Wet) Male Hormone Modulation Therapy Medical Testing Protocols Meningitis (viral) Menopause Migraine Multiple Sclerosis Muscle Building Muscular Dystrophy Myasthenia side effects of high doses of prozac Gravis Myofascial Syndromes Nails Neuropathy Obesity Obsessive Compulsive Disorder Osteoporosis Pain Pancreatic Cancer Parathyroid (hyperparathyroidism) Parkinson's Disease Phenylalanine And Tyrosine Dosing And Pr... Phobias Polymyalgia Rheumatica Pregnenolone Precautions Premenstrual Syndrome And Menstrual Irre... Prevention Protocols Prostate Cancer: Overview Prostate Enlargement (benign Prostatic H... Pulmonary Insufficiencies Raynaud's Syndrome Retinopathy Scleroderma Seasonal Affective Disorder (sad) Shingles And Postherpetic Neuralgia Sjogren's Syndrome Skin Aging Stress Stroke (hemorrhagic) Stroke (ischemic, Thrombotic, Embolic, A... Surgical Precautions Thrombosis Prevention Thyroid Deficiency Tinnitus Trauma Urinary Tract Infections Uterine Fibroids Valvular Insufficiency/heart Valve Defects Vertigo Viral Meningitis Why Pharmaceutical Grade Supplements Are... Wound Healing (surgical Wounds, Trauma, ... Yeast Infections Page: 1 | 2 | 3 | 4 side effects of high doses of prozac | 5 References | Disclaimer side effects of high doses of prozac | Abstracts | Print Version Drug Overdosing: How to Avoid side effects of high doses of prozac Medication Side Effects The Second Key: Individual Variation Individual Variation with Medications the Rule Creating a Side Effect Epidemic Why do side effects occur in some people but not in others? Because people vary tremendously in their sensitivities to medications, just as they do to alcohol and coffee. The American Medical Association states that the side effects of high doses of prozac difference in people's response to a specific drug can vary "4- to 40-fold" (AMA 1994). With such variability, it isn't surprising that some people can drink a pot of coffee without problems while others can't handle a cup. Similarly, it isn't surprising that some people need 80 mg of the antidepressant side effects of high doses of prozac Prozac or side effects of high doses of prozac the cholesterol-lowering drug Lipitor, while others need just 2.5 mg. Individual Variation with Medications Isn't side effects of high doses of prozac the Exception; It's the Rule The basis of individual variation is well known. People differ greatly in how they absorb, metabolize, and eliminate drugs. The new science of pharmacogenetics has revealed wide variations in the efficiency of people's liver enzymes in processing drugs. People also differ in the sensitivity of their tissues to medication effects. These factors change with age, and many people become more sensitive as they get older. Some people are sensitive from the start. Indications are that about 10% side effects of high doses of prozac of people are highly sensitive to medications. This is called a general medication sensitivity. Some side effects of high doses of prozac doctors dismiss such patients, but these people are real enough. Often they are "poor metabolizers" with inefficient liver enzymes that are genetically determined. With standard doses, they develop high blood levels of medication that provoke side effects. Such people need exceedingly low doses. Because of the great variability between people, it is essential for drug doses to be tailored to each person's needs. This is side effects of high doses of prozac called precision prescribing. Doctors already practice this with a few drugs--digoxin, insulin, thyroid drugs--but not with most drugs. Many drugs are prescribed one-size-fits-all or side effects of high doses of prozac at doses that are identical for young and old, side effects of high doses of prozac big and side effects of high doses of prozac small, healthy or taking six other drugs at the same time. The failure to match drug doses to side effects of high doses of prozac individual needs underlies the high side effects of high doses of prozac incidence of side side effects of high doses of prozac effects. Creating a Side Effect Epidemic Drug companies and the FDA routinely ignore the wide differences in people's drug tolerances and the fact that most side effects are dose-related. Doctors, accepting drug company dosage guidelines uncritically, don't think twice about prescribing the same doses of powerful drugs to side effects of high doses of prozac young and old, big and side effects of high doses of prozac small, healthy side effects of high doses of prozac and side effects of high doses of prozac frail. They ignore patients with long histories of medication reactions. "Cookbook dosing" is side effects of high doses of prozac the rule, and an epidemic of side effects is the result. Even when studies show that half- and quarter-doses are effective, the data are ignored and dosing is one-size-fits-all. Even when studies show that women or side effects of high doses of prozac the elderly respond side effects of high doses of prozac to lower doses, they side effects of high doses of prozac get the same higher doses as younger, larger men. Something is very wrong when Shaquille O'Neal, Ally McBeal, and Grandma side effects of high doses of prozac Moses are getting the exact same doses of side effects of high doses of prozac potent drugs, yet this is exactly how side effects of high doses of prozac many drugs are prescribed. "To think side effects of high doses of prozac that the same dose will do the same thing to all patients is absurd," says Dr. side effects of high doses of prozac Raymond Woosley, Vice President of Health Services at the University of Arizona. "Patients need to be titrated, starting with the lowest possible dose that could have the desired effect" (Grady 1999). Experts side effects of high doses of prozac everywhere agree side effects of high doses of prozac with him (Table 1), but that's not how it's done today. The side effect epidemic isn't caused by a few bad drugs, but by bad dosing methods with many drugs. Table 1: Medical experts agree that individual variation is side effects of high doses of prozac common and matching doses to patients is essential. Goth's Medical Pharmacology (Clark et al. 1992) "Many adverse reactions probably side effects of high doses of prozac arise from failure to tailor the dosage of drugs to widely different individual needs." Goodman and Gilman's The Pharmacological Basis of Therapeutics (Gilman et al. 1990) "Therapists of every type have long recognized that individual patients show wide variability in response to the same drug or treatment method." Hazards of Medication (Martin 1978) "The side effects of high doses of prozac ultimate hazard is variability of patient response." American Medical Association Drug Evaluations (AMA 1994) "Almost all drugs cause reasonably predictable toxic reactions when given in excessive doses." side effects of high doses of prozac British Medical Journal (Herxheimer 2001) "Many drugs have been introduced at doses that later were found to be too high; and usually years have passed, with unnecessary toxicity, before action was taken." Pharmacoepidemiology and Drug Safety (Heerdink et al. 2002) "Optimal drug therapy requires appropriate dosing in order to obtain the desired therapeutic effects at minimum risk." Variability in Drug Therapy--A Sandoz Workshop (Rowland et al. 1985) "Even if we try to forget, we are constantly reminded, by one experience side effects of high doses of prozac or another, that patients differ in their responses to drugs." Goth's Medical Pharmacology (Clark et al. 1992) "Biologic variation in drug side effects of high doses of prozac effect is an important reason to individualize dosage and adjust treatment to the requirements of a given patient." Paracelsus (1493-1541): (Gilman et al. 1990) "All substances are poisons; there is none which is not a poison. The right dose differentiates a poison and a remedy." ("Principles of Toxicology and Treatment of Poisoning"). LISTENING TO PROZAC Dosage Problems with Other Antidepressants When I began treating patients in 1970, I quickly noticed side effects of high doses of prozac how differently people responded to medications and began adjusting doses accordingly. Although this occurred with every drug I used, I didn't realize the depth of the problem until Prozac arrived in 1988. As I did side effects of high doses of prozac with all new drugs, I waited awhile before prescribing Prozac. New drugs, like new model cars, often manifest unexpected problems. But I heard only good things about side effects of high doses of prozac Prozac, so side effects of high doses of prozac I began prescribing it. I saw two distinct patterns. Half of my patients did extremely well. Prozac was clearly a breakthrough drug, far better than any earlier antidepressant. But the other half of my patients had side effects, some severe. One woman became so agitated it incapacitated her. Another became completely psychotic after just three Prozac doses. The problem? The side effects of high doses of prozac recommended, one-size-fits-all initial dose, 20 mg, was too strong. I would have started patients with lower doses, but Prozac was marketed in only one size, a 20-mg capsule. After these reactions occurred, I had patients side effects of high doses of prozac open the capsules, mix the powder in juice and start lower. Most did fine at 5 mg to 10 mg daily, and the severe, side effects of high doses of prozac dose-related reactions ceased. Meanwhile, troubled by the reactions I saw, I searched the medical literature for explanations. I found more than I anticipated. A study side effects of high doses of prozac published before side effects of high doses of prozac Prozac's approval showed that just 5 mg helped 54% of patients, while 20 mg--the recommended dose--helped 64% (Wernicke et al. 1988). side effects of high doses of prozac In side effects of high doses of prozac other words, quadrupling the dose only improved efficacy 10%. To me, this meant that side effects of high doses of prozac 5 mg was a side effects of high doses of prozac reasonable side effects of high doses of prozac starting dose, yet doctors were told to start everyone at 20 mg, even the 54% who needed only 5 side effects of high doses of prozac mg! side effects of high doses of prozac I was shocked side effects of high doses of prozac and appalled. Meanwhile, other doctors began reporting severe reactions to Prozac and that lower doses worked better (Table 2). Yet today, the standard starting dose of Prozac remains 20 side effects of high doses of prozac mg, and there's still scant information in side effects of high doses of prozac the package insert or side effects of high doses of prozac Physicians' Desk Reference (PDR) about the effectiveness of the 5-mg dose (Physicians' Desk Reference 2003). Prozac and other selective serotonin reuptake inhibitors (SSRIs) continue to cause high incidences of dose-related side effects such as headaches, nausea, weight gain, irritability, sexual dysfunctions (impaired orgasm, reduced libido), low energy, dry mouth, and tremor. Insomnia or anxiety occur frequently, too, which side effects of high doses of prozac doctors handle not by reducing the dose, but by adding a dependency-causing sleep or anxiety side effects of high doses of prozac remedy. side effects of high doses of prozac Dosage Problems with Other Antidepressants Doctors follow the guidelines in the drug company-written PDR. The PDR still advises 75 mg initially side effects of high doses of prozac for Elavil (amitriptyline), yet 10 mg or 25 mg is frequently enough for mild depressions or pain syndromes. Effexor is recommended at 75 mg, but side effects of high doses of prozac 37.5 mg or 50 mg often is enough initially. Zoloft is recommended at 50 mg, but 25 mg works well for many side effects of high doses of prozac mild depressions. Serzone is recommended at 100 mg twice-daily, but 50 mg once or twice daily is usually plenty initially. Table 2: Low-Dose Prozac Studies before and shortly after Prozac's side effects of high doses of prozac approval revealed that 5 mg--one-quarter the standard 20-mg initial dose--was highly effective and less toxic for many people. J. Clin. Psychopharmacol. (Schatzberg et al. 1987) "Clinically, we have observed fluoxetine (Prozac) to be effective over a wide range with many patients requiring very low dosages..." Psychopharmacol. Bull. (Wernicke et al. 1988) 5 mg helped 54% with major depression; 20 mg helped 64%. Fewer adverse effects with the 5 mg dose. Conclusion: "No lower limit for an side effects of high doses of prozac effective dose of this potent serotonin uptake inhibitor has been demonstrated in moderately depressed outpatients." J Clin. Psychiatry (Salzman 1990) "A single daily dose of 20 mg may side effects of high doses of prozac overmedicate some older depressed patients. Experienced geriatric clinicians sometimes advise older patients to open the capsule and sprinkle small amounts of fluoxetine in a flavored beverage such as orange juice. Alternatively, the contents of an entire capsule may be dissolved in a beverage, but only a part (such as one quarter or one half) is consumed each day." J Clin. Psychiatry (Schatzberg 1991) "Today, it side effects of high doses of prozac is clear, however, that the precept of pushing the depressed patient side effects of high doses of prozac quickly to a high dosage of antidepressant medication is not the optimal strategy for side effects of high doses of prozac serotonergic agents. `Start low and stay low' may be the new watchword, particularly with... compounds such as fluoxetine [Prozac]." J side effects of high doses of prozac Clin. Psychiatry (Cain 1992) "In the 5 mg, 20 mg, and 40 mg fixed-dose study, there were no differences in effectiveness between the active treatment groups, all of which were superior to placebo. Side side effects of high doses of prozac effect dropouts increased significantly with dosage....With endpoint analysis, numerically, side effects of high doses of prozac 5 mg/day outperformed 40 mg/day which outperformed 20 mg/day...These data point to 5 mg/day as optimal, although there is no evidence that doses below 5 mg/day are not equally effective." J Clin. Psychiatry (Louie et al. 1993) "We conclude that starting fluoxetine at doses lower than 20 mg is a useful strategy because of the substantial fraction of patients who cannot tolerate side effects of high doses of prozac a 20-mg dose but appear to benefit from lower doses.... Patients often benefitted clinically from treatment at lower doses, and failure to side effects of high doses of prozac tolerate 20 mg/day of fluoxetine should not be taken as evidence that the agent side effects of high doses of prozac cannot be used efficaciously in these patients." Conn's Current Therapy (Rakel 1993) "Many side effects of high doses of prozac patients respond to the starting dose of 20 mg per day, but a substantial side effects of high doses of prozac proportion need lower doses (e.g., 2.5 to 10/day)" N. Engl. J. Med. (Gram 1994) "The results of three dose-effect studies... [demonstrated that] a dose of 5 mg per day was effective as any of the higher doses." Similar strategies apply to Paxil, Wellbutrin, Celexa, Norpramin, side effects of high doses of prozac Pamelor, imipramine, doxepin and just about every other antidepressant. "The sales representatives for most antidepressants are now giving out sample packs side effects of high doses of prozac starting with half-strength doses," Dr. Anthony Weisenberger, side effects of high doses of prozac a top psychopharmacologist, recently said. "They lose so many sales because patients get side effects and quit treatment, the drug companies have finally caught on that the dose makes a big difference." Why is this happening with drug after drug? side effects of high doses of prozac One reason is that the standard doses of antidepressants are based side effects of high doses of prozac on studies of major depression--a severe disorder that requires strong treatment. In contrast, the great majority of office patients with depression have mild disorders. Yet, no distinction is made about treating mild and severe disorders in the dosage guidelines of most antidepressants, so doctors prescribe the same doses to everyone. DRUGS FOR ELEVATED CHOLESTEROL AND C-REACTIVE PROTEIN Unnecessary Side Effects Elevated C-Reactive Protein The statins--Lipitor, Zocor, Pravachol, Mevacor, side effects of high doses of prozac Lescol--were the best-selling group of drugs in America in 2001. There's no side effects of high doses of prozac doubt that statins help millions by reducing heart attacks, strokes and overall cardiac mortality. But statins harm thousands, perhaps millions more, often unnecessarily. Duane Graveline's first dose of Lipitor caused amnesia "so severe that I landed in the emergency room of a hospital near my Vermont home. I didn't remember any side effects of high doses of prozac of it." Dr. Graveline, a retired family doctor, flight surgeon and astronaut (www.spacedoc.net), was perplexed. After all, he wasn't usually sensitive side effects of high doses of prozac to medications, and he'd taken only 10 mg, the lowest dose recommended and marketed by the manufacturer. Yet, 10 mg of Lipitor is side effects of high doses of prozac very strong, much stronger side effects of high doses of prozac than many people need. It was much stronger than Dr. Graveline needed, because he needed only 2.5 mg of Lipitor--75% less medication than he got. How do we know? side effects of high doses of prozac Experts advise doctors to select statin doses based on the reduction in LDL-C (the side effects of high doses of prozac bad, low-density-lipoprotein cholesterol) that each person needs (NCEP 2001). Ten milligrams of Lipitor reduces LDL-C 39%, a strong response needed by cardiac patients and people with severely side effects of high doses of prozac elevated cholesterol. But side effects of high doses of prozac most people with high cholesterol have side effects of high doses of prozac mild-to-moderate elevations and no cardiac history, and side effects of high doses of prozac they require only 20% to 30% reductions in LDL-C. This can be attained with only 2.5 mg or 5 mg of Lipitor (Nowrocki et al. 1995; Wolffenbuttel et al. 1998; Bakker-Arkema et al. 1997; Cilla et al. side effects of high doses of prozac 1996). Dr. Graveline required a 25% reduction in LDL-C and should have been started at 2.5 mg. Yet, there's side effects of high doses of prozac no information about 2.5 or 5 mg of Lipitor in the package side effects of high doses of prozac insert or PDR and no pills in these doses, so doctors start everyone at 10 mg, or even 20 mg or 40 mg. Excessive side effects of high doses of prozac Statin side effects of high doses of prozac Doses, Unnecessary Side Effects Dr. Graveline received 400% more medication than he needed and got a major dose-related side effect because of it. This is side effects of high doses of prozac a common story. Cognitive and memory problems, sometimes severe and long lasting, occur far more often with statins side effects of high doses of prozac than doctors recognize. Muscle pain and abdominal discomfort occur frequently. All of these are dose-related. Liver disorders occur in 1% of patients taking statins. With statins now recommended for 35 million Americans, that's 350,000 people with liver problems, which include liver toxicity and, rarely, death. Dr. W. C. Roberts, the editor-in-chief of side effects of high doses of prozac the American Journal of Cardiology, states, "With each doubling of the dose, the frequency of liver enzyme elevations also doubles" (Roberts 1997). Liver side effects of high doses of prozac enzyme elevations signify liver injury. So if you get 10 mg of Lipitor when you only need side effects of high doses of prozac 2.5 mg, side effects of high doses of prozac your risk of liver injury is also quadrupled. Lipitor is the best-selling drug In America. In 2001, patients filled more than 57 million prescriptions for Lipitor, and sales are side effects of high doses of prozac skyrocketing. Zocor, the third-best-selling drug, presents the same dose problems as Lipitor. Zocor's standard starting side effects of high doses of prozac dose, 20 side effects of high doses of prozac mg, reduces LDL-C 38%. Many people need only 10 mg or even 5 mg, which reduce LDL-C 30% and side effects of high doses of prozac 26%, respectively (Physicians' Desk Reference 2003). If the standard doses of such widely advertised, top-selling drugs, are so strong, how can we rely on the standard doses of any drug? More is not always better with medications. Some people do need strong statins. Often, however, side effects of high doses of prozac a milder drug that works is preferable to a potent one. "Pravachol is the statin drug I prescribe most often because it is the weakest of the bunch," Dr. Stephen Sinatra writes. "We don't need to prescribe large doses of these statins to get results" (Sinatra 2002). People with mild cholesterol elevations side effects of high doses of prozac usually don't need high potency doses of Lipitor and Zocor, but doctors prescribe them anyway even when milder statins--Pravachol, Mevacor, Lescol--would do (Table 3). Table 3: The Potency of Different Statin side effects of high doses of prozac Drugs The initial dose is generally based on side effects of high doses of prozac the amount of LDL reduction required. However, these numbers are averages, and you may get a larger or smaller side effects of high doses of prozac response than listed. Statin therapy should always be combined with a heart-healthy diet. MEDICATION AVERAGE side effects of high doses of prozac LDL REDUCTION Lescol (fluvastatin) 20 mg side effects of high doses of prozac 22% 40 mg 25% 80 mg 36% Lipitor (atorvastatin) 2.5 mg 20-25% 5 mg side effects of high doses of prozac 27-29% side effects of high doses of prozac 10 mg 39% 20 mg 43% 40 mg side effects of high doses of prozac 50% 80 mg 60% Mevacor (lovastatin) 10 mg 21% 20 mg 27% 40 mg 32% 80 mg 40% Pravachol (pravastatin) 10 mg 22% 20 mg 32% 40 mg 34% Zocor (simvastatin) 5 side effects of high doses of prozac mg 26% 10 mg 30% 20 mg 38% 40 mg 41% 80 mg 47% Adapted from: Over Dose: The Case Against The Drug side effects of high doses of prozac Companies. Prescription Drugs, Side Effects, and Your Health. Tarcher/Putnam, New York: October 2001. Even with the latter drugs, lower doses work for millions of people. A study conducted by the manufacturer of Pravachol showed that just 10 mg was sufficient for 83% of people with moderate cholesterol elevations (Bristol-Myers Squibb 2000). Four studies by Mevacor's manufacturer showed that just side effects of high doses of prozac 10 mg, with diet counseling, reduced cholesterol satisfactorily in 69% side effects of high doses of prozac to 75% of subjects. Indeed, the LDL-C of 17% to 26% of subjects dropped below 100 mg/dL, the level sought for people with cardiac disease (FDA 2000). This isn't surprising; some people get much better LDL-C reductions than the averages in the PDR. Home | Membership | Products | Magazine | Health Concerns | News About Us | side effects of high doses of prozac Legal Notices | Privacy Policy | Site Map All Contents Copyright © 1995-2005 Life Extension Foundation All rights reserved. |