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By Brendan I. KoernerPrint | E-mail | Discuss | Alerts | Newsletters | RSS | Help HomeNews prozac vs zoloft & Politics4Arts & Life4Business & Tech4Health & Science4Style & Shopping4Travel & Food4Sports4Slate on NPR4Output Options4About Us4Search SlateAdvanced Searchexplainer Answers to your questions about the news.Prozac vs. WellbutrinHow do newer antidepressants work?By Brendan I. KoernerPosted Tuesday, March 23, prozac vs zoloft 2004, at 2:23 PM PT The Food and Drug Administration has asked pharmaceutical companies to revise the warning labels that accompany 10 popular antidepressants, in order to alert consumers to the possible risk of suicide. According to the Los Angeles Times, seven of the 10 affected drugs—Prozac, Zoloft, Paxil, Luvox, Celexa, Lexapro, and Effexor—are classified as serotonin reuptake inhibitors. How do the other three medications—Wellbutrin, Serzone, and Remeron—differ?The oddballs, often referred to as "atypical antidepressants," prozac vs zoloft target multiple receptors in the brain, while older selective serotonin reuptake inhibitors like Prozac and Zoloft focus on a single target. And contrary to prozac vs zoloft the Times rundown, most pharmacologists consider Effexor a member of the multiple-receptor group, rather than a traditional SSRI.The SSRIs work prozac vs zoloft by slowing the brain's absorption of serotonin, a prozac vs zoloft neurotransmitter that helps control mood. Serotonin is prozac vs zoloft attracted to receptors within the brain, and those receptors contain enzymes that break down—or "reuptake"—the mood-regulating chemical. SSRIs inhibit the action of those enzymes, so a person taking such prozac vs zoloft a drug prozac vs zoloft experiences a resultant rise in their serotonin levels. Continue Article But serotonin is not the only brain chemical that plays a role in mental well-being. prozac vs zoloft Neurochemistry researchers believe that a lack of dopamine prozac vs zoloft or norepinephrine (also known as norardrenaline) also contributes to depression. So, many of the prozac vs zoloft newer atypical antidepressants, which hit the market after the SSRIs prozac vs zoloft debuted in the late 1980s and early 1990s, work to prozac vs zoloft heighten the brain's supply prozac vs zoloft of dopamine or norepinephrine.Take Wellbutrin, the brand name for GlaxoSmithKline's bupropion. Though prozac vs zoloft the drug's mechanism of action isn't entirely understood, it's generally believed to inhibit prozac vs zoloft strongly the reuptake of norepinephrine and to inhibit more modestly the absorption of dopamine. Remeron (mirtazapine), meanwhile, stimulates certain nerves to release more norepinephrine, in addition to blocking certain serotonin receptors. Effexor (venlafaxine) is often characterized as a serotonin-norepinephrine reuptake inhibitor, since it stalls the brain's absorption of both neurotransmitters.Serzone (nefazodone) is similar to the SSRIs in that it primarily affects serotonin levels (although it may impact norepinephrine, too). But it's considered more powerful, in that it not only prozac vs zoloft inhibits serotonin reuptake, but completely blocks a serotonin receptor known as prozac vs zoloft 5-HT2A."Powerful" doesn't necessarily imply greater efficacy, however, and many patients prozac vs zoloft will still respond better prozac vs zoloft to SSRIs than atypical antidepressants. Side effects are a key consideration for doctors and vary greatly from person to person. Serzone, for example, is reputed to cause fewer incidents of sexual dysfunction and insomnia than SSRIs. But the drug is prozac vs zoloft also known to cause liver problems in some patients. Wellbutrin is also believed to cause fewer sexual side effects than its SSRI predecessors, but it can also cause uncomfortable nervousness, especially early in the treatment cycle.Next question?Brendan I. prozac vs zoloft Koerner is a contributing editor at Wired and a fellow at the New America Foundation. Photograph of the MRI brain scan on Slate's home page by Royalty-Free/Corbis.More explainerHow Do Sharks Find Their Prey?And is it a good idea to punch one in the face?posted June 27, 2005Daniel EngberScientologists vs. PsychiatristsWhy they don't get along.posted June 24, 2005Daniel EngberWhat's a "Simulated" Baseball Game?Fantasy baseball, for real.posted June 22, 2005Daniel prozac vs zoloft EngberThe American University in Cairo?What makes a foreign university "American"?posted June 20, 2005Daniel EngberWhat's So Great About Tygacil?Is it really a new class of antibiotic?posted June 17, 2005Daniel EngberSearch for more Explainer in our archive.What did you think prozac vs zoloft of prozac vs zoloft this article?Join the Fray, our reader discussion forumPOST A MESSAGE   READ MESSAGES News & PoliticsA Supreme Court ConversationI want to begin with prozac vs zoloft the Ten Commandments cases. As I've said before ... 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LLC | User Agreement and Privacy Policy | All rights reserved The Aftermath Of Prozac, Zoloft, Luvox, Fen-Phen, And Many Other Serotonergic Drugs SIGHTINGS The Aftermath Of Prozac, Zoloft, Luvox, Fen-Phen, & Many Other Serotonergic Drugs By Dr. Ann Blake Tracy - Executive Director, International Coalition For Drug Awareness www.drugawareness.org 5-6-00 Dr. Ann Blake Tracy, a PhD in Psychology and Health Sciences, has specialized for 10 years in adverse reactions to serotonergic medications. She is the prozac vs zoloft executive director of the International Coalition for Drug Awareness (www.drugawareness.org) and author of the book PROZAC: PANACEA OR PANDORA? (800-280-0730) WARNING: IT SHOULD BE NOTED THAT A GRADUAL TAPERING OFF OF MEDICATIONS IS SAFEST WITHDRAWAL METHOD TO AVOID SERIOUS prozac vs zoloft WITHDRAWAL EFFECTS (Often there is the terrible withdrawal associated with the SSRIs. Unless patients are warned to come very slowly off these drugs by shaving minuscule amounts off their pills each day, as opposed to cutting them in half or taking a pill every other day, they can go into terrible withdrawal which is generally delayed several months. This withdrawal includes bouts of overwhelming depression, terrible insomnia and fatigue, and can include life-threatening physical effects, psychosis, or violent outbursts.) Note: Keep in mind that these drugs are all serotonergic agents and prozac vs zoloft clones or "copy cat" drugs of Prozac - the first SSRI antidepressant introduced to the market in America. Basically what applies to one, applies to the others. For instance we have more data out on Prozac because it has been around longer, but as the mode of action is the same for all of prozac vs zoloft these meds the effects will be the same for the other drugs on this list as it is for Prozac. If we are discussing one prozac vs zoloft drug, similar effects would be expected from any other company's version of the drug. In fact it would be more prozac vs zoloft honest to give them the titles of Prozac #1, Prozac #2, Prozac #3, etc. rather than the brand names they have been given, from the second clone, Zoloft, to the latest Prozac clone, Celexa. My concern is that each new SSRI introduced seems to be a little stronger on serotonin reuptake and therefore potentially more dangerous. And the all too common practice of going from one SSRI to another blocks additional receptors and magnifies the harmful effects prozac vs zoloft of these medications. It is crucial to learn that according to medical research the theory behind prozac vs zoloft this group of drugs is invalid. Known as serotonin reuptake inhibitors. They are designed to block serotonin in the brain, thereby increasing brain levels of this neurotransmitter. Yet for three decades researchers have been intensely interested in serotonin because LSD and PCP produce their psychedelic effects by mimicking serotonin. Elevated serotonin is prozac vs zoloft found in: psychosis or schizophrenia, mood disorders, organic brain disease, mental prozac vs zoloft retardation, autism and Alzheimer's. While low levels of the metabolism of serotonin (which also produces high serotonin), are found in those with: depression, anxiety, suicide, violence, arson, substance abuse, insomnia, violent nightmares, impulsive behavior, reckless driving, exhibitionism, hostility, argumentive behavior, etc. The drugs increase serotonin and decrease the metabolism of serotonin leading to any and all of the above results. This information is extremely crucial for patients and physicians to learn as soon as possible. We have a high rate of use of prozac vs zoloft these drugs nationwide. Raising serotonin and lowering the metabolism of serotonin in such a large number of people can produce very serious, widespread and long term problems for all of society. So why are we now in the 90's being told that increased serotonin is good for us? Is it because it is good for the pocketbooks of the manufacturers? One prozac vs zoloft manufacturer is running full page newspaper and magazine ads and half hour TV infomercials to bring in over $7 million daily, while on the prozac vs zoloft other hand they are prozac vs zoloft settling Prozac suicide cases for huge amounts of money in exchange for silence prozac vs zoloft from victim's families on the details of those settlements. The silence in the court cases insures that the drug will be allowed to finish out its patent time, thus bringing in the highest possible profits for the company. They know that with $7 million coming in daily, they can afford to settle a large number of prozac vs zoloft lawsuits and prozac vs zoloft still come out "smelling like prozac vs zoloft a rose" financially. Eli prozac vs zoloft Lilly has been sued for Prozac related deaths in numerous state prozac vs zoloft and federal courts with most of these cases being settled or dismissed - many were dismissed due to the unethical manipulation of the prozac vs zoloft Wesbecker verdict (see time line for details). We have witnessed no decrease in suicide, but increases in murder/suicide, suicide, unwed pregnancies, domestic violence, manic-depression, MS, hypoglycemia, diabetes, bankruptcies, divorce, mothers (parents) killing children, road rage, school shootings, cancer, Chronic Fatigue Syndrome, and fibromyalgia since these serotonergic drugs have become so popular and I relate it directly to the effects of these drugs. The death toll has continued to climb drastically since I wrote PROZAC: PANACEA OR PANDORA? Some of the cases you may be familiar with prozac vs zoloft are: Mr. and Mrs. Phil Hartman (Zoloft), Prozac was found in the prozac vs zoloft van of Mark Barton, the prozac vs zoloft Atlanta day trader, who recently killed his family and others in a shooting spree before taking his own life; prozac vs zoloft Neal Furrow, in LA Jewish school shooting was reported to have been court ordered to be on Prozac along with several other medications; the Salt Lake Family History Library shooting, school shootings in Littleton, Colorado (Luvox), Atlanta, Georgia, Springfield, Oregon (Prozac), and Caldwell, Idaho; another boy in Pocatello, ID in prozac vs zoloft 1998 who in seizure activity from Zoloft had a stand off at the school; 15 year old Chris Shanahan (Paxil) in Rigby, ID who out of the blue killed a woman; the prozac vs zoloft shooting at the lottery in Connecticut last spring by Matthew Beck (Luvox) that left five dead in a murder/suicide; the New York City Subway bombing by Edward Leary (Prozac); little 10 year old Timmy (Prozac) in southern Florida; Nick Mansies (Paxil) in New Jersey who was convicted of killing prozac vs zoloft a little boy who was selling cookies door to door; in prozac vs zoloft Orange County, CA Dana Sue Gray (Paxil) who prozac vs zoloft co-workers described as a prozac vs zoloft very caring nurse killed several elderly people; Officer Stephen Christian (Prozac) one of the finest officers on the Dallas prozac vs zoloft Police force, who ran into a police substation shooting at prozac vs zoloft fellow officers and was killed; 13 year old Chris Fetters (Prozac) in Iowa who killed her favorite aunt; David Rothman (Prozac) killed two co-workers and himself at the Dept. of Agriculture in Ingelwood, CA; Williams Evans (Zoloft) shot one co-worker at the Ohio Bureau of Employment Services before shooting himself prozac vs zoloft in Columbus, OH; Winatchee, WA where 43 people were wrongfully imprisoned in a false accusation of sexual abuse "witch hunt" fury started prozac vs zoloft by a child under the influence of Prozac and Paxil; Christopher Vasquez (Zoloft) killed Michael McMorrow in Central Park; Megan Hogg (Prozac) duct taped prozac vs zoloft the mouths and noses of her three little girls and took a handful of pills; Vera Espinoza (Prozac) in Randolph, VT shot prozac vs zoloft her small son and prozac vs zoloft daughter before shooting herself; an elderly man (Prozac) in Layton, UT axed his wife prozac vs zoloft and daughter to death; prozac vs zoloft Margaret Kastanis (Prozac) used a knife and hammer to kill her three children before stabbing herself to death; an elderly man (Paxil) in Dallas, TX strangled prozac vs zoloft his wife before shooting himself twice in the chest; Larramie Huntzinger (Zoloft) blacked out and ran his car into three prozac vs zoloft young girls killing two in Salt Lake City, UT; Mary Hinkelman (Prozac), a nurse in Baroda, MI shot her two small daughters and her sister before shooting herself; Lisa Fox (Prozac) shot her small son and her dog before prozac vs zoloft shooting herself in Brighton, MI; Debi Louselle (Zoloft) shot daughter and then herself in Salt Lake City, UT; a father in Wyoming shot his wife, daughter and baby grand-daughter then himself after only days on Paxil; a mother (Prozac) in Pleasant Grove, UT killed her 17 year old son with a sledge hammer while he slept before she attempted suicide by drinking draino; Larry Butzz, a superintendent prozac vs zoloft of schools in Ames, IA shot his wife, son and daughter before shooting himself - many cases pending in court prozac vs zoloft are not mentioned. This is only a handful of MANY, MANY more cases - there would not be room for anything else if I continued prozac vs zoloft listing the cases. A few additional famous victims: Princess Di (Prozac) and Dodi Fayed -via their driver Henri Paul (Prozac), Monica Lewinsky (Prozac, Zoloft, Effexor, Serzone and Phen-Fen), Chris Farley (Prozac), Pres. Clinton's ex-partner Jim Mc Dougal (Prozac), Abby Hoffman (Prozac), Del Shannon (Prozac), Danielle Steele's son (Prozac), INXS singer Michael Hutchence (Prozac), Sarah - Dutchess of York (Phen-Fen) The latest prozac vs zoloft figures show Prozac has prozac vs zoloft about 44,000 adverse reports filed with the FDA. Out of those reports there are about 2500 prozac vs zoloft deaths with the large majority of them linked to suicide or violence. The suicide statistics relating to women are shocking. According to the CDC there prozac vs zoloft are about 30,000 prozac vs zoloft suicides yearly in the United States. Out of those about 6,000 are women - a ratio of about 4.3 to 1, male to female. About twice as many women as men are treated for depression demonstrating that generally men are more than 8 times as lethal in their suicidal gestures as women. Women were known to use less lethal means until prozac vs zoloft the SSRI prozac vs zoloft antidepressants hit the market. But on Prozac and Paxil, women committed 40% of the suicides - many were strikingly violent and clearly leaving no means for rescue. (Remember that because Prozac was the first of this group of drugs prozac vs zoloft its track record gives us a vision of what is to come with other serotonergic antidepressants, especially when they are so powerful in the reuptake of serotonin.) TIME LINE OF CRITICAL INFORMATION prozac vs zoloft DISCOVERED SINCE THE BOOK: *NOTE: Any prozac vs zoloft documents beginning with PZ are prozac vs zoloft Lilly documents on Prozac which have been ferreted out by attorneys and are now being used in lawsuits against the drug company. (Christian vs. Eli Lilly, by Vickery & Waldner, Houston, TX) - - Mid 1950's: Dr. Felix Sulman began his research on those who suffer from high serotonin levels because of an inability to metabolize serotonin. He found that serotonin is a stress neuro-hormone leading even rabbits, the prozac vs zoloft most docile of creatures, to be aggressive. He coined the term "serotonin irritation syndrome." He found that those who were unable to break down serotonin would have the levels increase. They "were in effect being poisoned by the serotonin produced by their own bodies, the irritation prozac vs zoloft victims suffered from migraines, hot flashes, irritability, sleeplessness, prozac vs zoloft pains prozac vs zoloft around the prozac vs zoloft heart, difficulty in breathing, a worsening of bronchial complaints, irrational tension and anxiety. . . prozac vs zoloft horrifying nightmares. It also caused his volunteers to sleep badly - that is, always on the edge of consciousness so that they were not properly rested - and to wake after only a few hours of sleep." (sleep apnea) He also found it caused pregnant women to abort. - - October, 1977: Slater, et.al., Inhibition of REM Sleep by Fluoxetine, a Specific Inhibitor of Serotonin Uptake, October 1977, at p. 385 - prozac vs zoloft Prozac was found to affect sleep habits, specifically to suppress deep sleep, which the scientists call REM (rapid eye movement) prozac vs zoloft sleep prozac vs zoloft in cats. By the fourth day of prozac vs zoloft drug treatment the cats receiving the larger doses, which had been friendly for years, began to growl and hiss. . . . After cessation of the drug treatment, the cats returned to their usual friendly behavior in a prozac vs zoloft week or two; those on the higher doses recovering more slowly. - - 1977: [PZ 1298 1999] "A total of six dogs from prozac vs zoloft the high dose group were removed from treatment ... due to severe occurrences of either aggressive behavior, ataxia, prozac vs zoloft or anorexia."] - - July 31, 1978: [PZ1061 1025-28, July 31, 1978] Human subjects began to be prozac vs zoloft used by Lilly in controlled clinical trials. The first group of patients showed no improvement in their depression, but there were a "large number of reports of adverse reactions." The first human to receive Prozac experienced "dystonia resembling an extrapyramidal reaction" - an uncontrollable, Parkinson-like shaking or trembling. - - July 23, 1979 [PZ 1297 969] prozac vs zoloft The clinical studies in depression showed that "some patients have converted from severe depression to agitation within a few days; in one case the agitation was marked and the patient had to be taken off drug. In future studies the use of benzodiazepines to control the agitation will be permitted." - - August 3, 1979: The clinical trials excluded patients who had serious suicidal risk. [E.g. control #001519, IND Protocol No. 14, August 3, 1979; PZ1135 695, July 2, 1986 prozac vs zoloft memorandum of Dr. Wernicke]. - - December 17, 1984: [PZ 65 449, report of Lilly to FDA] Lilly reported to the FDA that benzodiazepines and other sedatives were given with Prozac throughout the clinical trials. This was to help offset the stimulant effect of prozac vs zoloft the drug. In a memorandum of Lilly scientist Charles Beasley [PZ 541 2007-08] issues of "agitation vs. sedation" and concomitant sedative medications like benzodiazepines (to control the agitation) are discussed. Concerns are that agitation in a suicidal patient can induce suicide. - - March 3, 1986 Lilly controlled the flow of information to the FDA and decided that suicide data on Prozac should not be evaluated, "in the safety-update for the FDA the number of suicides and suicide attempts will not be especially evaluated." [PZ 879 1966, March 3, 1986 prozac vs zoloft telex] - - September 12, 1986: German BGA very concerned with the risk of suicide and ultimately prozac vs zoloft approved Prozac on the condition that physicians be prozac vs zoloft warned of the risk of suicide and told to consider prozac vs zoloft using sedatives and closely monitor prozac vs zoloft patients. [PZ 878 1383, report of Lilly consultant Pohlmeier; PZ 2467 299, September 12, 1986] Lilly actually warned physicians in Germany and prozac vs zoloft other countries that this measure "can be necessary" to minimize the risk of suicide, [PZ 1341 402, December 6, 1989 prozac vs zoloft German warning; PZ 2469 490] prozac vs zoloft - - February 7, 1990: In response to the Harvard study, Teicher, et al., Lilly's top scientist, Leigh Thompson, told prozac vs zoloft his fellow executives that "Lilly can go down the tubes if we lose Prozac". [PZ 1941 827, February 7, 1990]. In the ensuing months Dr. Thompson spoke frequently with his principal FDA regulator about the issue, once at 6:15 in the morning. [PZ 391 1959, July 18, prozac vs zoloft 1990]. Lilly later described the man as "our defender". [PZ1941 2256, September 12, 1990] - - May prozac vs zoloft 29, 1990, Lilly added "suicidal ideation" in the section dealing with post-marketing reports. [PZ883 562, July 26, 1990 memorandum] - - September 14, 1990: Contrary to the advice of his staff, Dr. Thompson told the Eli Lilly Board of Directors that suicide and hostile prozac vs zoloft acts were probably, caused by the patients' underlying disorders rather than Prozac. [PZ542 2101, September 14, 1990; PZ4002 889, Board Minutes]. The staff was concerned because they knew that this issue was never studied during the clinical trials. - - September 11, 1990: Note from Dr. Bruce Stadel, Chief of the Epidemiology Branch, attaching an analysis done by prozac vs zoloft Dr. David Graham, Section Chief within the Epidemiology Branch, of Lilly's July prozac vs zoloft 17, 1990 submission to the FDA prozac vs zoloft on the Prozac/suicidality/violence issue. The prozac vs zoloft following factors were (a) prozac vs zoloft brought to the attention of those in the higher echelons of the FDA, but (b) prozac vs zoloft ignored, discounted or "trashed" by prozac vs zoloft them: #1 Lilly's analysis improperly excluded 76 out of 97 suicides; as Dr. Stadel expressed it, prozac vs zoloft "[i]t is inappropriate in a safety analysis to exclude such a large proportion of case"; #2 Lilly admitted that its clinical trials "were not designed prozac vs zoloft for the prospective evaluation of suicidality" and that "[i]n these trials, patients with current suicidal ideation were prozac vs zoloft excluded"; #3 Lilly admitted that the HAMD-3 rating scale it used to assess suicidality in clinical trials prozac vs zoloft was inadequate; and that prozac vs zoloft Lilly's statements about violence only demonstrated "how great under-reporting is" and that "[t]he actual data showed a higher percentage of treatment-emergent suicidality among fluoxetine (2.9% than tricyclic (0.8%) patients . . . [which percentage] was similar to that reported by Teicher." - - July 1, 1992: A study lead by Dr. Lorne Brandes of the Manatoba Institute of Cell Biology in Winnipeg, Canada was published in CANCER RESEARCH linking the two most popular anti-depressants, Elavil and Prozac to cancer. - - 1993(?): A study headed by Edward Domino showed LSD flashbacks and LSD reactions induced by Prozac. - - June 9, 1994: The New York Review of Books article by Dr. Sherwin Nuland slams Peter Kramer for pushing Prozac in his book Listening to Prozac. He prozac vs zoloft pointed out that all docs are taught in med prozac vs zoloft school this little poem about serotonin: "This man was prozac vs zoloft addicted to moanin', confusion, edema, and groanin', intestinal rushes, great tricolored blushes, and died from too much prozac vs zoloft serotonin." He listed constriction of lungs and intestines, diarrhea, wheezing, flushing, mental confusion, tightening of bronchioles, and lessening conscious control over behavior from increases prozac vs zoloft in serotonin. "Moreover, . . . it is still too early to arrive at a reliable estimate of possible dangers that may appear in the long term," and 15% dropped out prozac vs zoloft of the clinical trials on Prozac because of adverse reactions. He also discussed the similarity of serotonin to the psychedelics like LSD and PCP. - - November, 1994: Krystal JH, Webb E, Cooney N, et al., "Specificity of Ethanol-like Effects Elicited in Serotonergic and Noradrenergic Mechanisms," ARCHIVES OF GENERAL PSYCHIATRY, Vol. 51, Issue 11, pgs 898-911, 1994 demonstrated that an increase in brain levels of either of two neurotransmitters, serotonin or noradrenalin, produces: #1 a craving for alcohol, prozac vs zoloft #2 anger, #3 prozac vs zoloft anxiety. They found prozac vs zoloft this to be especially true prozac vs zoloft for those who have a history of alcoholism. An increase serotonin in turn increases noradrenalin. Numerous reports have been made by reformed alcoholics who are being "driven" to prozac vs zoloft alcohol again after being prescribed a serotonergic drug. And many other patients who had no prozac vs zoloft previous history of alcoholism have continued to report an "overwhelming compulsion" to drink while using these drugs. (A few personal accounts: #1 A young woman, a recovering alcoholic, reported that during the eight month prozac vs zoloft period she had been using Prozac prozac vs zoloft she found it necessary to attend AA meetings every day in order to fight prozac vs zoloft off the strong compulsions to begin drinking again. #2 In the prozac vs zoloft Southeastern United States a middle aged psychologist, also a recovering alcoholic, after being prescribed Prozac, found herself needing to attend AA meetings morning, noon, and night to keep from destroying the sobriety she had achieved. #3 A young father, who was Mormon and had never before in his life used alcohol, found himself drinking Ever Clear and exhibiting prozac vs zoloft bizarre as well as violent behavior, after being prescribed Prozac and Ritalin. #4 A young mother who had never used alcohol before began drinking large amounts within weeks of being prescribed Prozac and quickly found herself prozac vs zoloft committed to a mental institution due to the psychotic behavior that resulted. Added to her Prozac prescription were anti-psychotic meds and electric shock treatments. She then began to experience seizures and was started on anti-seizure meds. #5 A concerned neighbor reported her prozac vs zoloft friend was drinking straight Vodka on a regular prozac vs zoloft basis after being prescribed Zoloft. #6 A daughter reported her father, sober for 15 years, began drinking again on Prozac. - - December, 1994: Not guilty verdict on Wesbecker wrongful death suit against Lilly's Prozac. - - Treatment emergent suicidality with Prozac has been prozac vs zoloft demonstrated to prozac vs zoloft be two to three prozac vs zoloft times higher than any other anti-depressant. (Jick, et al., Antidepressants and Suicide) - - May, 1995: Judge prozac vs zoloft John Potter who presided over the Wesbecker case filed documents to demand that Lilly be forced to disclose the secret deal they made prozac vs zoloft with prozac vs zoloft the plaintiffs to withhold very damaging evidence in exchange for prozac vs zoloft settlement. In his pleading to the court Potter stated, "Lilly sought to buy not just the verdict, but the court's judgment as prozac vs zoloft well." Potter accused Lilly of "giving the verdict the widest possible publicity" accompanied by the prozac vs zoloft claim that Lilly had "proven in a court of prozac vs zoloft law that Prozac was safe." Furious with prozac vs zoloft Lilly's attempt to prozac vs zoloft turn his courtroom into an advertising agency for Prozac, he claims his motion reflects "the court's duty to protect the integrity of the judicial system." He believes, as do prominent legal ethicists, that a full and open disclosure of the terms of the settlement is prozac vs zoloft a necessary public safety issue. - - July, 1997: Mayo Clinic found that the increased serotonin, which produces blood clotting, was causing a gummy glossy substance to build up on heart valves. Dr. Heidi Connolly with the Divisions of Cardiovascular Diseases and Internal Medicine, who headed the study stated, "We do know that fenfluramine and phentermine [Fen-Phen] alter the way the brain chemical serotonin is metabolized, and serotonin that circulates in the blood can cause valve injury." Fenfluramine produces a rapid release of serotonin, inhibits serotonin reuptake, and may also have receptor agonist activity. The study's revelations should send a loud and very clear warning throughout the medical community concerning all serotonergic medications - - August 25, 1997: Letter to Dr. Tracy, "I caught the last part of your presentation on Radio Station KEX, Portland, while flipping through the dial last prozac vs zoloft night. prozac vs zoloft I was prozac vs zoloft flabbergasted to hear you speak of the horrible potential side effects from Prozac, which I have been taking for approximately four years, particularly since I have been diagnosed recently with cardiomyalgia, severe artery disease, congestive heart failure and also fibromyalgia. (I was a very "well" person prior to taking the Prozac and prozac vs zoloft am now exhausted all the time, with horrible aching joints and considerable pain prozac vs zoloft and a massive heart problem.) The adverse cardiovascular effects from Prozac, the one drug in this class of drugs out long enough to have somewhat of track record, are listed in the drug information sheet put out by the manufacturer. The "frequent" effects listed are prozac vs zoloft hemorrhage and hypertension. The "infrequent" effects include very serious adverse effects: congestive heart failure, myocardial infarct, tachycardia, angina pectoris, arrhythmia, hypotension, migraine syncope and vascular headache. - - September, 1997: prozac vs zoloft Redux and Phen-Fen were pulled from the market. - - October 20, 1997: prozac vs zoloft Dr. Candace Pert, Research Professor at Georgetown University Medical Center, past head of the brain chemistry department at the National Institute of Health, and author of the new book, MOLECULES OF EMOTION, sounded an alarm in TIME, October 20. She stated, "I am alarmed at the monster that Johns Hopkins neuroscientist Solomon Snyder and I created when we prozac vs zoloft discovered the simple binding assay for drug receptors 25 years ago. Prozac and other antidepressant serotonin-receptor-active compounds may also cause cardiovascular problems in some susceptible people after long-term use, which has become common practice despite the lack prozac vs zoloft of safety studies." (emphasis added) As we are being led to believe these drugs produce effects only in prozac vs zoloft the brain, Dr. Pert accuses the medical profession of oversimplifying the action of these drugs and adds that "the public is being misinformed about the precision of these selective serotonin-uptake inhibitors." It is critical that both physicians and patients be made aware of these prozac vs zoloft adverse physical reactions. She points out that the medical profession not only oversimplifies the action of these drugs in the prozac vs zoloft brain, but "ignores the prozac vs zoloft body as if it exists merely to carry the head around!" And that, "these molecules of emotion regulate every aspect of our physiology." The body plays a very significant role in how we feel and act the way we do. This fact can no longer be ignored. - - Serotonin and serotonin receptors exist throughout the body, as well prozac vs zoloft as the brain, and every aspect of the body's physiology is affected by these serotonergic medications. In prozac vs zoloft fact approximately 90% of the body's serotonin prozac vs zoloft is produced in the intestinal tract. prozac vs zoloft According to Dr. Michael Gershon of New York's Columbia Presbyterian, this is the reason why Prozac produces so many gastrointestinal side effects. - - March, 1998: Two new studies published - one that shows Prozac so strongly inhibits one particular serotonin receptor that this produces both obesity and seizures and the other discusses the blockage prozac vs zoloft of muscle and neuronal nicotinic acetylcholine receptors prozac vs zoloft indicating prozac vs zoloft interactions between the serotonergic and prozac vs zoloft cholinergic prozac vs zoloft systems in the central nervous system. - - April, 1998: Our next generation of guinea pigs - one month before a 15 year old on Prozac, Kip Kinkel, in Springfield OR killed his parents and two classmates the American Psychiatric Association and the American Academy of Pediatric Psychiatrists asked the FDA to consider the serotonergic antidepressants for use in children as young as two and drugs for anxiety, aggression and manic depression in babies only one month old! The use of Prozac among young children ages 6 prozac vs zoloft - 12 has increased prozac vs zoloft an alarming 400% from 1995 (51.000 new prescriptions) to 1996 (203,000 new prescriptions). - - June, 1999: CLINICAL PSYCHIATRY NEWS reported that Dr. Malcolm Bowers a psychiatrist at Yale has found that physicians are not paying enough attention to patient factors that could make initiation of SSRIs dangerous. He found that "SSRI-induced psychosis has accounted for 8% of all general hospital psychiatric admissions over a recent 14-month period." And "What is surprising is that this particular group of side effects is really underplayed." (The 8% figure represents over 150,000 SSRI induced psychotic breaks per year!!!!!!!) - - Warning: Children so often get coughs and colds, yet using a cough or cold medication with dextromethorphan could cause the serotonin syndrome, a very serious and potentially fatal adverse reaction and/or produce PCP reactions. - prozac vs zoloft - Serotonin syndrome remains an often misdiagnosed or prozac vs zoloft unrecognized fatal reaction due to the medical profession being prozac vs zoloft so uninformed about this drug-induced disorder. - - Developing brains are far more vulnerable than adult brains and brain damage generally becomes more apparent after the brain is fully developed, rather than immediately. Increases in cortisol produce brain damage while medical research shows that one single 30mg dose of Prozac DOUBLES the level of cortisol. prozac vs zoloft This drastic increase in cortisol causes a multitude of serious physical prozac vs zoloft reactions including prozac vs zoloft impairment of linear growth, as well as impairing the development and regeneration of the liver, kidneys, muscles, etc. In light of so many unspeakable tragedies, prozac vs zoloft I have grown weary of all the silly philosophical discussions we have heard since Kramer's LISTENING TO PROZAC came out. Patients are dying or having their health destroyed mentally as well as physically (when do we begin prozac vs zoloft to discuss the very serious physical side effects associated with high levels of serotonin?). These patients and their families are frantically searching for prozac vs zoloft answers while this research sits right under our noses and could easily be made available to them. The widespread use of Prozac and its clones is not a statement of either their safety or their effectiveness. It is a statement about the effectiveness of an infinite marketing budget and incredible advertising campaign! These drugs have very serious physical side effects, as well as dangerous psychiatric side effects. To prevent further tragedy this medical research must be acknowledged and addressed in headline news without delay rather than prozac vs zoloft remain buried in seldom read medical research documents as has been the case prozac vs zoloft in the past with prozac vs zoloft other mind- altering medications, once thought to be safe, which were subsequently prohibited by law, ie. LSD, PCP, cocaine, etc.. Oct. 1998 note from a British nurse: "I started having bad reactions . . . Oct '96 I found Prozac to be causing joint and muscle pain itself . . prozac vs zoloft . signs of Cushing's Syndrome. . . I was very pro-Prozac until last October and wouldn't have listened to anything said against it until I got problems (thought it was saving my life, while all the time it was insidiously and slowly killing me!) When prozac vs zoloft I first heard about your book on the Internet I was interested but quite sceptical. However, since reading prozac vs zoloft it and having suffered so many problems with Prozac, I have come to the conclusion that the book is brilliant, and a life-line as far as I am concerned. I tried to fault the research and reasoning, but could not and still can't. I would like to extend my thanks to you for your heroic stance on this enormously important issue. I have tremendous respect and admiration for your hard work, determination and courage in pursuing this subject so vigorously, against prozac vs zoloft so much powerful opposition for the benefit of people like me. Your integrity puts many, if not most doctors and psychiatrists to shame. It is reassuring to find that there are a few people who are prepared to fight for the truth for the benefit of mankind." "PROZAC: PANACEA OR PANDORA? is an incredible compilation of medical data that will lay the groundwork to educate other professionals and the general public about the new SSRI antidepressants - Prozac, Zoloft, Paxil, Luvox, Effexor and prozac vs zoloft Serzone." . . . prozac vs zoloft Jeff Wise, psychologist, Salt Lake County Drug and Alcohol Abuse "In prozac vs zoloft 15 years of reading books on drugs I have never read a book with more information or so well prozac vs zoloft documented as PROZAC: PANACEA OR PANDORA? . . . Dr. Kevin Millet, Bountiful, UT "As I lecture to physicians nationwide on the medical use of psychoactive drugs PROZAC: PANACEA OR PANDORA? always accompanies me in my brief case. . . . Dr. Bruce Woolley, neuropsychopharmacologist, Brigham Young Univ. 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ORDER PHONE: 1-800-280-0730 WEB ADDRESS: members.aol.com/atracyphd & www.drugawareness.org ORDER ADDRESS: Cassia Publications, PO Box 1044, West Jordan, UT 84084 PRODUCTS: (All prices in US funds<<<) ( Postage and handling: $4 in US, $8 in Canada & Western Europe, and $10 elsewhere - per book - or for any 6 tapes ordered without a book - no charge for postage on tapes ordered with a book.) Book: PROZAC: PANACEA OR PANDORA? ($19.95) Audio Tapes: "Help! I Can't Get Off My Antidepressants! (1 1/2 hr - $9.95); BYU Lecture (Christian - LDS; 45 min prozac vs zoloft - $4.95); Dr. Tracy's favorite radio shows: Interview with prozac vs zoloft David and Fawn Christopher (1994, Very informative prozac vs zoloft - health oriented, 1 hr - $6.95), Art Bell Show (Sep. 1999, 4 hours, set of four tapes packed with information - $29.95), Interview with Frosty Fowler (1997, Christian oriented, 1 hr - $6.95); Liberty Radio interview (1999, politically prozac vs zoloft oriented, 1 prozac vs zoloft hr $6.95) & more to follow. SIGHTINGS HOMEPAGE http://www.sightings.com This Site Served by TheHostPros Sertraline ( Zoloft , Lustral ) versus fluoxetine ( Prozac ) Sertraline versus fluoxetine in the treatment of major depression: a combined analysis of five double-blind comparator studies by Feiger AD, Flament MF, Boyer P, Gillespie JA. aFeiger Health Research Center, Wheat Ridge, Colorado, USA. Int Clin Psychopharmacol. 2003 Jul;18(4):203-101 ABSTRACT The aim of this study was to examine response and remission rates in outpatients treated with sertraline or fluoxetine who were suffering from two depression subtypes: anxious-depression and severe depression. Data were pooled from five double-blind studies comparing prozac vs zoloft fluoxetine versus sertraline for the treatment of DSM-III-R or IV major depression. Clinical outcome prozac vs zoloft was assessed using the Hamilton Depression Rating Scale (HAM-D) and the Clinical Global Impression-Improvement scale (CGI-I). One thousand and eighty-eight patients were randomized, with 654 (60%) meeting criteria for anxious depression and 212 (19%) meeting criteria for high severity depression. For the prozac vs zoloft total sample, prozac vs zoloft treatment response was similar for both sertraline and fluoxetine. In the high severity subgroup, the mean (+/-SD) HAM-D score at week 12 was 8.9+/-5.7 for sertraline and 10.8+/-6.9 for fluoxetine (P=0.07), and the mean (+/-SD) CGI-I score was 1.5+/-0.7 for sertraline and 2.0+/-1.1 for fluoxetine (P=0.005). CGI-I responder rates were 88% versus 71% (P=0.03) in prozac vs zoloft the high severity subgroup, and 84% versus 79% (P=0.16) in the anxious-depression subgroup. Overall, sertraline and fluoxetine showed comparable antidepressant prozac vs zoloft efficacy, although sertraline may offer an advantage in those patients with severe depression. SSRIs Options Sertraline dosage Sertraline and sex Sertraline prozac vs zoloft and OCD Long-term sertraline Sertraline v fluoxetine Sertraline v amisulpride Sertraline and depression Sertraline and noradrenaline Sertraline for elderly depressives Sertraline and personality disorders Sertraline and psychomotor performance Non-melancholic depression: prozac vs zoloft sertraline v imipramine SSRIs: fluoxetine (Prozac ) versus sertraline (Zoloft, Lustral) Off-label use of selective serotonin reuptake inhibitors (SSRIs) Refs HOME HedWeb Future Opioids BLTC prozac vs zoloft Research Paradise-Engineering Utopian Pharmacology The Hedonistic Imperative When Is It Best prozac vs zoloft To Take Crack Cocaine? The Good Drug Guide The Responsible Parent's Guide To Healthy Mood Boosters For All The Family |