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Prozac Overview / Prozac Side Effects What Is Prozac? Fluoxetine ( prozac information Prozac ) a serotonin-specific drug is used then the patient does prozac information not respond to heterocyclic antidepressants. Fluoxetine is in a class of drugs called selective serotonin reuptake inhibitors. Fluoxetine affects chemicals in the brain that may become unbalanced and cause depression or mood disturbances, eating disorders, or obsessive or compulsive symptoms. Prozac prozac information is an SSRI. Specific Uses for Prozac: This drug is used mainly in the treatment of depression. It is prozac information also prozac information used to treat other psychological disorders, these include: OCD ( obsessive-compulsive disorder), panic disorder, and antiphobic effects. This drug may also be used in prozac information the treatment of bulimia. Fluoxetine is also used to treat premenstrual dysphoric disorder (PMDD), symptoms of which occur in the week prozac information or two before a woman's menstrual prozac information period and commonly include irritability, mood swings, and tension as well as the physical symptoms of bloating and breast tenderness. Prozac Side Effects: Anxiety or nervousness. Abnormal sweating, change in prozac information appetite, constipation, diarrhea, headache, nausea, sedation, seizure, skin rash, stomach cramps, or trouble sleeping. (If you experience any of the above serious side effects, stop taking Prozac and seek emergency medical attention or contact your prozac information doctor immediately) Click here prozac information to read what SSRI user are prozac information saying about their side effects. Prescription Drug Warnings for Prozac: Prozac is habit forming. You can become physically and psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for prozac information longer than is directed by your doctor. Withdrawal effects may occur if Prozac is stopped suddenly after several weeks of continuous use. DO NOT use Prozac for more than 12 months without speaking to your doctor. Do not take fluoxetine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last 2 weeks. Serious, prozac information and sometimes fatal, reactions have occurred when these medicines have been used together. Also, do not take fluoxetine prozac information if you are taking thioridazine (Mellaril). Dangerous, even fatal irregular heartbeats may occur if these medicines are taken together. You must wait prozac information 5 weeks after stopping fluoxetine before taking thioridazine (Mellaril). Avoid alcohol while taking Prozac. Alcohol may increase drowsiness and dizziness caused by Prozac. You should tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding while prozac information you are taking Prozac. Use caution when driving, operating machinery, or performing other hazardous activities. Fluoxetine may cause prozac information dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Prozac may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine without first talking to your doctor. prozac information Alternatives to SSRI's prozac information like Prozac: If you are considering taking an SSRI like Prozac, I would ask that you give an alternate solution a try. SSRI's did nothing for me but make me dependant on them and when prozac information I tried to stop taking them, I sank into very deep states of depression for weeks at a time. When you stop taking the SSRI, it will really mess up the chemical balance in your brain. Remember, by taking an SSRI, your brain is synthetically forced to create the chemicals prozac information in the prozac information brain that help to rebalance your condition. When these chemicals are no longer being forced into your body by the SSRI, the results can be hazardous and dangerous. If you start taking an SSRI, plan on taking it for a very long time as it is very hard to quit and stay sane. In addition, you will literally spend thousands of dollars on prescription costs over the years you have to take the drug. There are a few excellent alternative solutions out there. Alternative herbal medicines like St. Johns Wort, Kava Kava, Valerian Root, prozac information 5-HTP and SAM-e have all been used in prozac information clinical studies with excellent results in patients prozac information with anxiety and depression prozac information related symptoms. Combination therapy products prozac information like Clarocet NRI can help provide natural chemical mood enhancement without the dangerous side effects of prescription drugs. Remember that any sort of chemical balancer, be it a prescription drug like Prozac or a natural alternaitve, only targets the symptoms of anxiety and depression. Though they can provide short term and long term relief, the only permanent solution is identifying your prozac information feelings prozac information and developing coping techniques that prozac information can help. Cognitive behavior therapy or consulting with a therapist prozac information can prozac information help you do this. Featured Prescription Medication Resource prozac information Partners Mental Health Center - Learn about modern medications and prozac information what they do. The health center prozac information details prescription drugs commonly used to treat anxiety, depression, ADHD and related emotional disorders. Learn the prozac information truth about how they work, as well as side effects prozac information and warning. Complimentary Therapy - Clarocet's line of natural, complimentary alternatives can help provide relief from many symptoms associated with anxiety, depression and ADHD. Eight out of Ten people are satisfied with their overall prozac information Clarocet experience. Four prozac information products that can help Adults, Teens and Children. ARTICLES ABOUT PRESCRIPTION DRUGS / MEDICATIONS: Go to Prescription Drug Articles Home Page How do I submit an article or personal experience? My Take on Prescription Drug "Treatment" - An article that overviews my experience and my take on how prescription prozac information drugs prozac information can and can't help. By Jake Van Der Borne (08/07/03) Side Effects and More - An article that prozac information overviews the side effects of popular prescription drugs. By Jake Van Der Borne (09/03/04) The Real Cost of Your Prescription Drugs - Are prozac information the prescription drug companies ripping you off? You will be surprised at the actual cost of your prescription prozac information drugs. By Sharon Davis and Mary Palmer (07/03/04) Selective Serotonin Reuptake Inhibitors (SSRI) - SSRI's: What they are and how they are believed to work. Read about warnings and side effects. By Jake Van Der Borne (08/12/03) MAOI: Monoamine Oxidase Inhibitor - What is an MAOI? How does it work? What can it do to you?. By Jake Van Der Borne (09/04/04) Anxiety Attack Management - Causes of anxiety, treatment options for anxiety, information resources for Xanax and more. By Dr. Johnson. (03/15/05) An Overview of Serotonin Syndrome - What prozac information is serotonin syndrome and what can I do to avoid prozac information it? By Jake Van Der Borne (04/21/04) Death of Our Daughter Due to Zoloft - A true story of zoloft and its effects. By Alan Kennedy (11/04/04) SUBMIT AN ARTICLE OR PERSONAL EXPERIENCE Prozac Top prozac information If you experience anxiety, depression or related symptoms, it is recommended that you consult a professional about your treatments options. Anxiety, Depression, prozac information social anxiety and related disorders are serious conditions that require the assistance of prozac information a doctor, psychologist, psychiatrist or other qualified practitioner. Consult a physician about taking Prozac with any non-prescription alternative. If you are planning on discontinuing prozac information Prozac you must speak with a doctor about slowly stopping this drug. The prozac information anxiety and depression information prozac information on this website is intended solely for informational purposes. Anxiety and Depression Solutions reserves all right to prozac information content and material on this website. Copyright - Anxiety and Depression Solutions - 2002- 2004. Prozac Prozac Buy Prozac Prozac Information Other Brand Names: prozac information Fontex, Prozac Durapack Generic Name: Fluoxetine Other Common Names: Fluoxetina Prozac (Fluoxetine HCl) is indicated for the treatment of depression. The efficacy prozac information of prozac information fluoxetine HCl was established in prozac information 5- and 6-week trials with depressed outpatients ( Drug Information Home > Prozac Popular Products Soma Fioricet Cialis Tramadol Carisoprodol Fluoxetine Fluoxetine Brand name: Prozac Drug monograph Contents Summary Pharmacology Indications Contraindications Warnings Precautions Adverse Effects Overdose Dosage Supplied Research Summary PROZAC Lilly Fluoxetine Use: SSRI. Depression: patients > 18 years of age - Initially, 20 mg in the morning; increase prozac information dosage gradually only after a trial period of several weeks if required. Maximum: 80 mg/day. Elderly patients: 20 mg/day. Use lower or less frequent dosage in patients with renal and/or hepatic impairment and those receiving multiple medications. When switching patients to a TCA, the TCA dosage may have to be reduced and plasma TCA concentrations may need prozac information to be monitored temporarily when fluoxetine is coadministered or hs recently been discontinued. Bulimia nervosa: Adults, 60 mg/day. Assess electrolyte levels prior to starting therapy. Obsessive-compulsive disorder: 20 - 60 mg/day. Prozac's long-term efficacy in bulimia (i.e., > 16 weeks) and in obsessive-compulsive disorder (i.e., > 13 weeks) has not been evaluated in controlled trials. Contraindications: Not to be used with an MAOI or within 14 days of discontinuing MAOI therapy. Allow at least 5 weeks after stopping Prozac before starting an MAOI. Do not administer thioridazine with prozac information Prozac or within 5 weeks after Prozac has been discontinued. Precautions: Pregnancy, lactation, patients < 18 years of age, elderly patients. History of allergic reactions, seizures, suicidal tendency, activation of mania/hypomania, MI or unstable heart disease, diabetes, severe renal or hepatic impairment, hypokalemia (following self-induced vomiting), hyponatremia, altered platelet function. Safety/efficacy of combined Prozac/electroconvulsive therapy not established. Side effects: Headache, nervousness, insomnia, drowsiness, prozac information fatigue or asthenia, prozac information anxiety, tremor, prozac information dizziness or lightheadedness, nausea, dry mouth, diarrhea, anorexia, excessive sweating. Less frequently, rash, pruritus, weight loss, sexual prozac information dysfunction, convulsions. Interactions: See Contraindications. Warfarin (monitor PT). Lithium levels may be increased or decreased (monitor). Use cautiously with other CNS-active drugs (e.g. tryptophan), agents prozac information highly bound to plasma protein or metabolized by the P450 2D6 prozac information system. St. John's Wort (increase in undesirable effects). Patient tips: Full therapeutic effect may be delayed until 4 or 5 weeks of treatment. May cause drowsiness, dizziness (NB driving). Restrict alcohol intake. Supplied: 10mg, 20 mg capsules; 20 mg/5 mL prozac information of mint-flavored syrup, 120 mL bottles. to top Pharmacology Antidepressant - Antiobsessional - Antibulimic The antidepressant, antiobsessional, and antibulimic actions of fluoxetine are presumed to be linked to its ability to inhibit the neuronal reuptake of serotonin. Fluoxetine preferentially inhibited the reuptake of serotonin into prozac information brain synaptosomes and platelets in rats and humans. In receptor binding studies, fluoxetine was shown to have only weak affinity for various receptor systems, namely opiate, serotonergic 5HT(1), dopaminergic, beta-adrenergic, alpha(2)-adrenergic, histaminergic, alpha(1)-adrenergic, muscarinic, and serotonergic 5HT(2) receptors. Unlike most clinically effective antidepressants, fluoxetine did not down-regulate beta-adrenergic receptors; however, prozac information like all tested antidepressants, it caused up-regulation of GABA-B receptors. Mixed effects have been observed on serotonergic receptor sensitivity. Pharmacokinetics: Fluoxetine is well absorbed after oral administration. In man, following a single 40 mg dose, peak prozac information plasma concentrations of fluoxetine ranged from 15 to 55 ng/mL 6 to 8 hours after dosing (range=1.5 to 12 hours). The capsule and oral solution dosage forms of fluoxetine are bioequivalent. Food appears to affect the rate but not the extent of absorption. Fluoxetine is extensively metabolized in the liver to norfluoxetine, and other, unidentified metabolites. Norfluoxetine, a desmethyl metabolite, is also a serotonin reuptake inhibitor; its pharmacological activity being similar to that of the parent drug. Norfluoxetine contributes to the long duration of action of fluoxetine. Elimination of metabolites occurs primarily in the urine with a prozac information smaller amount also being present in the feces. Clinical Issues Related to Metabolism/Elimination: The complexity of fluoxetine's metabolism prozac information has several consequences which may potentially affect its clinical use. Accumulation and Slow Elimination: The half-life of fluoxetine after a single dose is 2 days (range 1 to prozac information 4 days) and after multiple dosing 4 days (range 2 to 7 days). The corresponding values for norfluoxetine are similar after single and multiple dosing, i.e., 8.6 and 9.3 days (range 4 to 15 days). After 30 days of dosing at 40 mg/day, plasma concentrations of fluoxetine and norfluoxetine ranged from 91 to 302 ng/mL and 72 to 258 ng/mL respectively. Plasma concentrations of fluoxetine were higher than those predicted from single dose studies, presumably because fluoxetine's metabolism prozac information is not proportional to dose. Norfluoxetine, however, prozac information appears to have linear pharmacokinetics. Steady state plasma levels are attained after 4 to 5 weeks of continuous drug administration. Patients receiving fluoxetine at doses of 40 to 80 mg/day over periods as prozac information long as 3 years exhibited, on average, prozac information plasma concentrations similar to those prozac information seen among patients treated for 4 to 5 weeks. Similarly because of the long half-lives of fluoxetine prozac information and norfluoxetine, it may take up to 1 to 2 months for the active drug substance to disappear from the body. This is of potential consequence in withdrawal of fluoxetine (see Warnings). Protein Binding: Approximately 94% of fluoxetine is protein bound. The interaction between fluoxetine and other highly protein bound drugs has prozac information not been fully evaluated, but may be important (see Precautions). Liver Disease: As might be predicted from its primary site of metabolism, liver impairment prozac information can affect the elimination of fluoxetine. In patients with alcohol-induced cirrhosis, the elimination half-life of fluoxetine was prolonged, with a mean prozac information of 7.6 days compared to the range of 2 prozac information to 3 days seen in subjects without liver prozac information disease; norfluoxetine elimination half-life was also delayed, with a mean duration of 12 days for cirrhotic patients compared to the range of 7 to 9 days in normal subjects. prozac information This suggests that the use of fluoxetine in patients with liver disease must be prozac information approached with caution prozac information (see prozac information Precautions and Dosage). prozac information Renal Disease: In single dose studies, the pharmacokinetics of fluoxetine and norfluoxetine were similar among subjects with all levels of impaired renal function including anephric patients on chronic hemodialysis. However, with chronic administration, additional accumulation of fluoxetine or its metabolites (possibly including prozac information some not yet identified) prozac information may occur in patients with severely impaired renal function and use of a lower or less frequent dose is advised (see Precautions). Age: The effects of age upon the metabolism of fluoxetine have not been fully explored. The prozac information disposition of single prozac information doses of fluoxetine in healthy elderly subjects (greater than 65 years of age) did not differ significantly from that in younger normal subjects. However, given the long half-life and nonlinear disposition of prozac information the drug, a single-dose study is prozac information not adequate to rule out the possibility of altered pharmacokinetics in the elderly, particularly prozac information if prozac information they have systemic illness or are receiving multiple drugs prozac information for concomitant diseases. to top Indications Depression: For the symptomatic relief of depressive illness. Bulimia Nervosa: Fluoxetine has been shown to significantly decrease binge-eating and prozac information purging activity when compared with placebo treatment. Obsessive-Compulsive Disorder: Fluoxetine has been shown to significantly reduce the symptoms of obsessive-compulsive disorder in double-blind, placebo-controlled clinical trials. The obsessions or compulsions must be experienced as intrusive, markedly distressing, time-consuming, or interfering significantly prozac information with the person's social or occupational functioning. The efficacy of fluoxetine in hospitalized prozac information patients has not been studied. The effectiveness of fluoxetine in long-term use (i.e., for more than 5 to 6 weeks in depression, for more than 16 weeks in bulimia nervosa, or for more than 13 weeks in obsessive compulsive disorder), has not been prozac information systematically evaluated in controlled trials. Therefore, the physician who elects to prozac information use fluoxetine for extended periods should periodically re-evaluate the long-term usefulness of the drug for the prozac information individual patient. to top Contraindications In patients with known hypersensitivity to the drug. MAO Inhibitors: There have been reports of serious, sometimes fatal, reactions (including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, and mental status prozac information changes that include extreme agitation progressing to delirium and coma) in patients receiving fluoxetine in combination with a MAO inhibitor and in prozac information patients who have recently discontinued fluoxetine and then started on a MAO inhibitor. Some cases presented with features resembling neuroleptic malignant syndrome. Therefore, fluoxetine should not be used in combination with a MAO inhibitor or within 14 days of discontinuing prozac information therapy with a MAO inhibitor. Since fluoxetine and its major metabolite have very prozac information long elimination half-lives, at least 5 weeks should be allowed after stopping fluoxetine prozac information before starting a MAO inhibitor. prozac information Limited reports suggest that i.v. administered dantrolene or orally administered cyproheptadine may benefit patients experiencing such reactions. to prozac information top Warnings Allergic Reactions (Rash and Accompanying Events): During premarketing testing of more than 5600 patients given fluoxetine, approximately 4% developed a rash and/or urticaria. Among these cases, almost a third were withdrawn from treatment because of the prozac information rash and/or systemic signs or symptoms associated with the rash. Clinical findings reported in association prozac information with these allergic reactions include prozac information rash, fever, prozac information leukocytosis, arthralgias, edema, carpal tunnel syndrome, respiratory distress, lymphadenopathy, proteinuria, and mild transaminase elevation. Most prozac information patients improved promptly with discontinuation of fluoxetine and/or adjunctive treatment with antihistamines or steroids, and all patients experiencing these events were reported to recover completely. In premarketing prozac information clinical trials 2 patients are known to have developed a serious cutaneous systemic illness. In neither patient was there an unequivocal diagnosis, but one was considered to prozac information have a leukocytoclastic vasculitis, and the other severe desquamation that was considered variously to be a vasculitis or erythema multiforme. Other patients have had systemic manifestations suggestive of serum sickness. Since the introduction of fluoxetine, systemic events, possibly related to vasculitis, have developed in patients with rash. Although these events are rare, they may be serious, involving the lung, kidney, or liver. Death has been prozac information reported to occur in association with these systemic events. Anaphylactoid events, including bronchospasm, angioedema, and urticaria alone and in combination, have been prozac information reported. Pulmonary events, including inflammatory processes of varying histopathology and/or fibrosis, have been reported rarely. These events have occurred with dyspnea as prozac information the only preceding symptom. Whether these systemic events and prozac information rash have a prozac information common underlying cause or are due to different etiologies or pathogenic processes is not known. Furthermore, a specific underlying immunologic basis for these events has not been identified. Upon the appearance of rash prozac information or of other allergic phenomena for which an alternative etiology cannot be identified, fluoxetine should be discontinued. Particular caution should be exercised in patients with a history of allergic reactions. Implications of the Long Elimination Half-Life prozac information of prozac information Fluoxetine: Because of the long elimination half-lives of fluoxetine and its major active metabolite norfluoxetine, changes in dose will not be fully reflected in plasma for several weeks, affecting both strategies for titration to final dose and withdrawal from treatment (see Pharmacology and Dosage). Even when dosing is stopped, active drug substance will prozac information persist in the body for weeks due to the long elimination prozac information half-lives of fluoxetine prozac information and norfluoxetine. This is of potential consequence when drug discontinuation is required or when drugs are prozac information prescribed that might interact with fluoxetine and norfluoxetine following discontinuation of fluoxetine. to top Precautions Anxiety and Insomnia: During premarketing clinical trials, anxiety, nervousness and insomnia were prozac information reported by 10 to 15% of patients treated with fluoxetine. These symptoms led to discontinuation of the drug in 5% of the patients. Weight Change: Significant weight loss, especially in underweight depressed patients, prozac information may be an undesirable result of treatment with fluoxetine. Mania/Hypomania: During premarketing clinical trials in a patient population comprised primarily of unipolar prozac information depressives, hypomania or mania occurred in approximately 1% of fluoxetine treated patients. The incidence in a general patient population which might also include bipolar depressives is unknown. The likelihood of hypomanic or manic episodes may be increased at prozac information the higher dosage prozac information levels. Such reactions require a reduction in dosage or discontinuation of the drug. Seizures: Fluoxetine should be used with caution in patients prozac information with a history of convulsive disorders. The incidence of seizures associated with fluoxetine during clinical trials did prozac information not appear to differ from that reported with other marketed antidepressants; however, patients prozac information with a history of convulsive disorders were excluded from these trials. Concurrent administration with electroshock therapy should be avoided because of the absence of experience in this area. prozac information There have been rare reports of a prolonged seizure in patients on fluoxetine receiving ECT treatment. Hypokalemia: Self-induced vomiting often prozac information leads to hypokalemia which may lower seizure threshold and/or may lead to cardiac conduction abnormalities. Electrolyte levels of bulimic patients should be assessed prior to initiation of treatment. Suicide: The possibility of a suicide attempt is inherent in depression and may persist until significant remission occurs. Therefore, high risk patients should be closely supervised throughout therapy and consideration prozac information should be given to the possible need for hospitalization. In order to minimize the opportunity for overdosage, prescriptions for fluoxetine should be written for the smallest quantity of drug consistent with good patient management. Concomitant Illness: Clinical experience with prozac information fluoxetine in patients with concomitant systemic illness is limited and it should be used cautiously in such patients, especially those with diseases or conditions that could affect metabolism or hemodynamic responses. Fluoxetine has not been prozac information evaluated or prozac information used to any appreciable extent in patients with a prozac information recent history of myocardial infarction or unstable heart disease. Patients with these diagnoses were systematically excluded from premarketing clinical studies. prozac information Retrospective evaluation of ECGs in some of these studies showed no conduction abnormalities that resulted in heart block. The mean heart rate was reduced by approximately 3 beats/minute. Fluoxetine should be prozac information given with caution to patients suffering from anorexia nervosa and only if the expected benefits (e.g., co-morbid depression) markedly outweigh the potential weight reducing effect of the drug. In patients with diabetes, fluoxetine may alter glycemic control. Hypoglycemia has occurred during therapy with fluoxetine and hyperglycemia has developed following discontinuation of the drug. As prozac information is true with many other types of medication when taken concurrently by patients with diabetes, insulin and/or oral hypoglycemic dosage may need to be adjusted when therapy with fluoxetine is instituted or discontinued. Since fluoxetine is extensively metabolized, excretion of unchanged drug in urine is a minor route prozac information of elimination. However, until adequate numbers of patients with severe renal impairment prozac information have been evaluated in the course of chronic treatment, fluoxetine should be used with caution in such patients. Since clearances of prozac information fluoxetine and norfluoxetine may be decreased in patients with impaired liver prozac information function including cirrhosis, a lower or less frequent dose should be used in such patients. Hyponatremia: Several cases of hyponatremia (some with serum sodium lower than 110 mmol/L) have been reported. The hyponatremia appeared to be reversible when fluoxetine was discontinued. Although these cases were complex with varying possible etiologies, some were possibly due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). The majority of these occurrences have been in older patients and in patients taking diuretics or prozac information who were otherwise volume depleted. Platelet Function: There have been rare prozac information reports of altered platelet function and/or abnormal results prozac information from laboratory studies in prozac information patients taking fluoxetine. prozac information While there have prozac information been reports of abnormal bleeding prozac information in prozac information several patients prozac information taking fluoxetine, it is unclear whether fluoxetine had a causative role. Occupational Hazards: Patients should be cautioned against driving an automobile or performing hazardous tasks until they are reasonably certain that treatment with fluoxetine does not affect them adversely. Pregnancy and Lactation: Safe use of fluoxetine during pregnancy and prozac information lactation has not been established. Therefore, it should not be administered to women of childbearing potential or nursing prozac information mothers unless, in the opinion of the treating physician, the expected benefits to the patient markedly outweigh the possible hazards to the child or fetus. In 1 breast milk sample, the concentration of fluoxetine plus norfluoxetine was 70.4 ng/mL. The concentration in the mother's plasma was 295 ng/mL. No adverse effects on the infant were reported. Children: Safety and effectiveness in patients below the age of 18 have not been established. Geriatrics: Elderly patients should initially receive fluoxetine in low prozac information dosage with slow progressive increases prozac information only if required and tolerated. Patients who have concomitant systemic illnesses or who prozac information are receiving other drugs concomitantly should be under careful observation at all dosage levels. Drug Interactions: Combined use prozac information of fluoxetine and MAO inhibitors is contraindicated (see Contraindications). There have been greater than 2-fold increases of previously stable plasma levels of other antidepressants when fluoxetine has been administered in combination with prozac information these agents. There have been reports of prozac information both increased and decreased lithium levels when lithium was used concomitantly with fluoxetine. Cases of lithium prozac information toxicity have been reported. Lithium levels should be monitored when these prozac information drugs are administered concomitantly. Five patients receiving fluoxetine in combination prozac information with tryptophan experienced adverse reactions, including agitation, restlessness and gastrointestinal distress. The half-life of concurrently administered diazepam may be prolonged in some patients. prozac information Experience with the use of fluoxetine in combination with other CNS-active drugs is limited and caution is advised if such concomitant medication is required (see Warnings). Drugs Tightly Bound to Plasma Protein: Because fluoxetine is prozac information highly bound to plasma protein, the administration of fluoxetine to a patient taking another drug which is tightly bound to protein (e.g., warfarin, digitoxin) may cause a shift in plasma concentrations potentially resulting in an adverse effect. Conversely, adverse effects may result from displacement of prozac information protein bound fluoxetine by other tightly bound drugs. P450 isozyme (IID6): Like other selective serotonin reuptake inhibitors, fluoxetine inhibits the specific hepatic cytochrome P450 isozyme (IID6) which prozac information is responsible for the metabolism of debrisoquine and sparteine. Although the clinical significance of this effect has not been established, inhibition of IID6 may lead to elevated plasma levels of co-administered drugs which are metabolized by this isozyme. Drugs metabolized by cytochrome P450IID6 include the tricyclic antidepressants (e.g., nortriptyline, amitriptyline, imipramine, and desipramine), phenothiazine neuroleptics (e.g., perphenazine and thioridazine), and Type 1C antiarrhythmics (e.g., propafenone and flecainide). General Anesthetics: Since little is known about the interaction prozac information between fluoxetine and general anesthetics, fluoxetine should be prozac information discontinued prozac information for as long as clinically possible prior to elective surgery. Dependence Liability: Fluoxetine has not been systematically studied, in animals or humans, for its potential for abuse, tolerance, or physical dependence. Physicians should carefully evaluate patients prozac information for history of drug abuse and follow such patients closely, prozac information observing them for signs of misuse or abuse of fluoxetine. to top Adverse Effects Commonly Observed: In prozac information clinical trials, the most commonly observed adverse events associated with the use of fluoxetine and not seen at an equivalent incidence among prozac information placebo treated patients were: prozac information CNS complaints, including headache, nervousness, insomnia, drowsiness, fatigue or asthenia, anxiety, tremor, and dizziness or lightheadedness; gastrointestinal complaints, including nausea, diarrhea, dry mouth and anorexia; and excessive sweating. Adverse Events Leading to Discontinuation of Treatment: Fifteen percent of approximately 4000 patients prozac information who received fluoxetine in North American clinical trials discontinued prozac information treatment due to an adverse prozac information event. The more common prozac information events causing discontinuation included: Psychiatric, primarily nervousness, prozac information anxiety, and insomnia; digestive, primarily nausea; nervous system, primarily dizziness, asthenia and headaches; skin, primarily rash and pruritus. In obsessive compulsive disorder studies, 12.1% of fluoxetine treated patients discontinued treatment early because of adverse events. prozac information Anxiety, and rash, at incidences of less than 2%, were the most frequently reported events. In bulimia nervosa studies, 10.2% of fluoxetine treated patients discontinued treatment early because of adverse events. Insomnia, anxiety and prozac information rash, at incidences of less than 2%, were the most frequently reported events. Serious Adverse Reactions: Suicidal thoughts and acts are far more common among depressed patients than in the general population. It prozac information is estimated that suicide is 22 to 36 times more prevalent in depressed persons than in the general population. A comprehensive meta-analysis of pooled data from 17 double blind clinical trials in patients with major depressive disorder compared fluoxetine (n=1765) with a tricyclic antidepressant (n=731) or placebo (n=569), or both. The pooled incidence of emergence of substantial suicidal ideation was 1.2% for fluoxetine, 2.6% for prozac information placebo, and 3.6% for tricyclic antidepressants. In countries where the drug has already been marketed, the following potentially serious adverse reactions have been reported: Interactions with MAO inhibitors and prozac information possibly other drugs, allergic reactions, cardiovascular reactions, syndrome of inappropriate ADH secretion, and grand mal seizure. Death and life-threatening events have been associated with some of these reactions, although causal relationship to fluoxetine has not been established. Postmarketing experience also confirms the profile of adverse reactions commonly reported during clinical trials with fluoxetine, including allergic skin reactions. Adverse Experience Reports: The pattern of adverse events for both fluoxetine and placebo was somewhat different in bulimia and obsessive compulsive disorder trials than in the depression studies, and is summarized in Table I. -------------------------------------------------------------------------------------------- Table prozac information I Treatment-Emergent Adverse Experience Incidence (>=5%) in Placebo-Controlled Clinical Trials for Depression, Obsessive-Compulsive Disorder and Bulimia Percentage of Patients Reporting Event Depression OCD Bulimia Body prozac information System/ Fluoxetine Placebo Fluoxetine Placebo Fluoxetine Placebo Adverse Event (N=1730) (N=799) (N=264) (N=89) (N=418) (N=210) Nervous headache 20.3 prozac information 15.5 prozac information 32.6 23.6 30.1 26.9 nervousness 14.9 8.5 14.4 14.6 10.8 5.2 insomnia 13.8 7.1 29.6 22.5 33.1 15.0 somnolence 11.6 6.3 17.1 6.7 12.7 7.1 anxiety 9.4 prozac information 5.5 13.6 6.7 16.3 11.1 tremor 7.9 2.4 9.1 1.1 13.7 2.0 dizziness 5.7 3.3 13.3 11.2 11.4 5.4 libido, decreased - - 11.4 prozac information 2.3 5.9 0.9 depression - - 8.0 14.6 10.1 16.4 emotional lability - - - - 2.7 7.8 Digestive nausea 21.1 10.1 26.5 13.5 29.7 13.5 diarrhea 12.3 7.0 18.2 13.5 7.5 6.7 dry mouth 9.5 6.0 12.1 3.4 9.9 8.6 anorexia 8.7 1.5 16.7 10.1 8.8 4.4 dyspepsia 6.4 4.3 prozac information 9.9 4.5 prozac information 10.7 6.7 gastrointestinal disorder - - 5.7 1.1 5.7 5.9 constipation - - 4.2 6.7 4.8 4.6 flatulence - prozac information - 3.4 5.6 - - Skin and Appendages sweating, excessive 8.4 3.8 7.2 - prozac information 8.9 1.6 rash - - 6.4 3.4 5.1 4.9 Body as a Whole asthenia - - 15.2 10.1 21.7 9.6 flu syndrome - - 9.9 6.7 10.1 5.9 back pain prozac information - - 2.7 5.6 3.9 7.0 infection - - - - 6.2 6.2 abdominal pain - - 4.9 11.2 9.6 6.5 myalgia - - - - 4.7 9.4 Respiratory upper respiratory infection 7.6 6.0 - - - - rhinitis - - 22.7 23.6 23.0 29.1 pharyngitis - - 10.6 9.0 11.1 5.5 sinusitis - - - - 5.7 6.9 yawn - - 7.2 - 11.1 0.8 Cardiovascular vasodilatation - - 5.3 - - - Urogenital menstrual disorder - - prozac information 3.4 5.6 8.3 4.8 dysmenorrhea - - 3.4 5.6 6.1 7.8 urinary frequency prozac information - - - - 6.2 1.6 urinary tract infection prozac information - - - - 5.1 2.0 -------------------------------------------------------------------------------------------- The following adverse reactions, were reported on at least one occasion by patients during treatment with fluoxetine either during clinical trials or after marketing. All reported events are included except those where a drug cause prozac information was remote or prozac information the event term so general as to be unhelpful. Multiple events may have prozac information been reported by a single patient and related to a single condition, which may have preexisted. Therefore, while the following events occurred during treatment with fluoxetine, they were not necessarily caused by it. Events are further classified within body system prozac information categories and enumerated in order of decreasing frequency using the following definitions: Frequent adverse events are prozac information defined as those occurring on 1 or more occasions in at least 1% of patients; infrequent adverse events are those occurring in less than 1% but at least 1/1000 patients; prozac information rare events are those occurring in less than 1/1000 patients. Allergic or Toxic: Frequent: Rash, pruritus. Infrequent: Chills and fever, urticaria, maculopapular rash. Rare: Allergic reaction, erythema multiforme, vesiculobullous rash, serum sickness, contact dermatitis, prozac information erythema nodosum, purpuric rash, leukocytoclastic vasculitis, leukopenia, thrombocythemia, arthralgia, angioedema, bronchospasm, lung fibrosis, allergic alveolitis, larynx edema, respiratory distress. Neurologic: Frequent: Headache, tremor, dizziness or lightheadedness, asthenia. Infrequent: Abnormal gait, prozac information ataxia, akathisia, buccoglossal prozac information syndrome, hyperkinesia, hypertonia, incoordination, neck rigidity, extrapyramidal syndrome, convulsions, photophobia, myoclonus, vertigo, migraine, tinnitus, hypesthesia, neuralgia, neuropathy, prozac information acute brain syndrome. Rare: Dysarthria, dystonia, torticollis, decreased reflexes, nystagmus, paralysis, paresthesia, carpal tunnel syndrome, stupor, coma, abnormal EEG, chronic brain syndrome, dyskinesia and other movement disorders (including worsening of preexisting conditions or appearance in patients with risk factors prozac information [e.g., Parkinson's disease, treatment with neuroleptics or other drugs known to be associated with movement disorders]) neuroleptic malignant syndrome-like events. Behavioral: Frequent: Insomnia, anxiety, nervousness, agitation, abnormal dreams, drowsiness and fatigue. Infrequent: Confusion, delusions, hallucinations, manic reaction, paranoid reaction, psychosis, depersonalization, apathy, emotional lability, euphoria, hostility, amnesia, increased libido. Rare: Antisocial reaction, hysteria, suicidal ideation, violent behaviors. Autonomic: Frequent: Excessive sweating. Infrequent: Dry mouth, constipation, urinary retention, vision disturbance, diplopia, mydriasis, hot flushes. prozac information Cardiovascular: Infrequent: Chest pain, hypertension, syncope, hypotension (including prozac information postural hypotension), angina pectoris, arrhythmia, prozac information tachycardia. Rare: Bradycardia, ventricular arrhythmia, first degree prozac information AV block, bundle branch block, myocardial infarct, cerebral ischemia, prozac information cerebral vascular accident, thrombophlebitis. Gastrointestinal: Frequent: Nausea, disturbances of appetite, diarrhea. Infrequent: Vomiting, prozac information stomatitis, dysphagia, eructation, esophagitis, gastritis, gingivitis, glossitis, melena, thirst, abnormal liver function tests. Rare: Bloody diarrhea, hematemesis, gastrointestinal hemorrhage, duodenal ulcer, stomach ulcer, mouth ulceration, hyperchlorhydria, colitis, enteritis, cholecystitis, cholelithiasis, hepatitis, hepatomegaly, liver tenderness, jaundice, increased salivation, salivary gland enlargement, tongue discoloration, fecal incontinence, pancreatitis. Respiratory: Frequent: Bronchitis, rhinitis, yawn. Infrequent: Asthma, dyspnea, hyperventilation, pneumonia, hiccups, epistaxis. Rare: Apnea, lung edema, hypoxia, pleural effusion, hemoptysis. Endocrine: Frequent: Weight loss. Infrequent: Generalized edema, peripheral edema, face edema, tongue edema, hypoglycemia, prozac information hypothyroidism, weight gain. Rare: Dehydration, gout, goitre, prozac information hyperthyroidism, hypercholesteremia, hyperglycemia, hyperlipemia, hyperprolactinemia, hypokalemia, hyponatremia, iron deficiency anemia, syndrome of inappropriate prozac information ADH secretion. Hematologic: Infrequent: Anemia, lymphadenopathy, hemorrhage. Rare: Bleeding time increased, leukocytosis, lymphocytosis, thrombocytopenia, thrombocytopenic purpura, prozac information thrombocythemia, retinal hemorrhage, petechia, purpura, sedimentation rate increased, aplastic anemia, pancytopenia, immune-related hemolytic anemia. Dermatologic: Infrequent: Acne, alopecia, dry skin, herpes simplex. Rare: Eczema, psoriasis, seborrhea, skin hypertrophy, skin discoloration, herpes zoster, fungal dermatitis, hirsutism, ecchymoses. Musculoskeletal: Frequent: Muscle pain, back pain, joint pain. Infrequent: Arthritis, bone pain, bursitis, tenosynovitis, twitching. Rare: Bone necrosis, osteoporosis, pathological fracture, chrondrodystrophy, myositis, rheumatoid arthritis, muscle hemorrhage. Urogenital: Frequent: Painful menstruation, sexual dysfunction, urinary tract infection, frequent micturition. Infrequent: Abnormal ejaculation, impotence, menopause, amenorrhea, menorrhagia, ovarian disorder, vaginitis, leukorrhea, fibrocystic breast, breast pain, cystitis, dysuria, urinary urgency, urinary incontinence. Rare: Breast enlargement, galactorrhea, abortion, dyspareunia, uterine spasm, prozac information vaginal hemorrhage, metrorrhagia, hematuria, albuminuria, polyuria, pyuria, epididymitis, orchitis, pyelonephritis, salpingitis, urethritis, kidney calculus, urethral pain, urolithiasis. Miscellaneous: Frequent: Chills. Infrequent: Amblyopia, conjunctivitis, cyst, ear pain, eye pain, jaw pain, neck pain, pelvic pain, hangover effect, malaise. Rare: Abdomen enlarged, blepharitis, cataract, corneal lesion, glaucoma, iritis, ptosis, strabismus, deafness, taste loss, moniliasis, hydrocephalus, prozac information LE syndrome. to prozac information top Overdose During clinical trials, there were 2 prozac information deaths among approximately 38 reports of acute overdose with fluoxetine, either alone or in combination prozac information with other drugs and/or alcohol. One death involved a combined overdose with approximately 1800 mg of fluoxetine and an undetermined amount of maprotiline. Plasma concentrations of fluoxetine and maprotiline were 4.57 mg/L and 4.18 mg/L, respectively. A second death involved 3 drugs yielding plasma concentrations as follows: Fluoxetine, 1.93 mg/L; norfluoxetine, 1.10 mg/L; codeine, 1.80 mg/L; temazepam 3.80 mg/L. One other patient who reportedly took up to 3000 mg of fluoxetine experienced 2 grand mal seizures that remitted spontaneously without specific treatment. Since vomiting prozac information occurred, the amount of drug absorbed may have been less than that ingested. In the postmarketing phase, there have been 16 confirmed reports of overdose of fluoxetine taken alone. The amount of drug ingested has varied from 80 mg to 2000 mg and the patients have ranged in age from 13 to 51 years. There have been no deaths in this group of patients, prozac information some of whom were treated prozac information vigorously with activated prozac information charcoal in the acute phase. Furthermore, patient recoveries prozac information were remarkable in the absence of serious adverse events with the exception of a 13 year old male who ingested 1880 mg and experienced 2 brief seizures but thereafter had an prozac information uneventful recovery. prozac information Since introduction, reports of death attributed to overdose of fluoxetine alone have been rare. Symptoms: Nausea and vomiting were prominent in overdoses involving higher fluoxetine doses. Other prominent symptoms of overdose included agitation, restlessness, hypomania, and other signs of CNS excitation, including prozac information seizures. Treatment: Establish and maintain an airway; ensure adequate oxygenation and ventilation. Activated charcoal, which may be used with sorbitol, may be as or more effective than emesis or lavage, and should be considered in treating overdose. Cardiac and vital signs monitoring is recommended, along with general symptomatic and supportive measures. Based on prozac information experience in animals, prozac information which may not be relevant to humans, fluoxetine-induced seizures which fail to remit spontaneously prozac information may respond to diazepam. There are no specific antidotes for fluoxetine. Due to the large volume prozac information of distribution of fluoxetine, forced diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit. In managing overdosage, consider the possibility of multiple drug involvement. The physician should consider contacting a poison control centre on the treatment of prozac information any overdosage. to top Dosage Since it may take up to 4 or 5 prozac information weeks to reach steady state plasma levels of fluoxetine, sufficient time should be allowed to elapse before dosage is gradually increased. Higher dosages are usually associated with an increased incidence of adverse reactions. Depression: Adults: The recommended initial dosage is 20 mg administered once prozac information daily in the morning. A gradual dose increase should be considered only after a trial period of several weeks if the expected clinical improvement does not occur. Bulimia Nervosa: Adult: The recommended dosage is 60 mg/day, although studies show that lower doses may also be efficacious. Electrolyte levels should be assessed prior to initiation of treatment. Obsessive-Compulsive Disorder: A dose range of 20 mg/day to 60 mg/day is recommended for the treatment of obsessive-compulsive disorder. For any indication, the total fluoxetine dosage should not exceed a maximum of 80 mg/day since clinical experience with doses above 80 mg/day is very limited. During maintenance therapy, the dosage should prozac information be kept at the lowest effective level. A lower or less frequent dosage should be used in patients with renal and/or hepatic impairment and in those on multiple medications. Geriatrics: A lower or less frequent dosage is also recommended in the elderly. Children: The prozac information safety and effectiveness of fluoxetine in patients prozac information below the prozac information age of 18 years prozac information have not been established. prozac information to top Supplied Liquid: Each 5 mL clear, colorless, prozac information syrup solution, with an odor of mint, contains: Fluoxetine HCl equivalent to fluoxetine 20 mg. prozac information Nonmedicinal ingredients: prozac information Benzoic acid, glycerin, mint flavor, purified prozac information water and sucrose. Amber glass bottles of 120 mL (M-5120). Capsules: 10 mg: Each green and grey capsule, printed with Lilly 3104 and Prozac 10 mg, contains: Fluoxetine HCl equivalent to fluoxetine 10 mg. Nonmedicinal ingredients: Silicone and starch. The capsule shell contains FD&C Blue No. 1, iron oxide yellow, titanium dioxide, gelatin, sodium lauryl sulfate, sodium propionate, benzyl alcohol, methylparaben, carboxymethylcellulose sodium and edetate calcium prozac information disodium. Amber bottles of 30 prozac information and 100. 20 mg: Each green and white capsule, printed with Lilly 3105 prozac information and Prozac 20 mg, contains: Fluoxetine HCl equivalent to fluoxetine prozac information 20 mg. Nonmedicinal ingredients: prozac information Silicone and starch. The prozac information capsule shell contains FD&C Blue No. 1, iron oxide yellow, titanium dioxide, gelatin, sodium lauryl sulfate, sodium propionate, benzyl prozac information alcohol, methylparaben, carboxymethylcellulose sodium and edetate prozac information calcium disodium. Amber bottles of 100. Store at 15 to 25°C. to top Research The research information is available separately on Internet Mental Health. Note: This information is from a Canadian monograph. There can be differences in indications, dosage forms and warnings for this drug in other countries. to top Internet Mental prozac information Health (www.mentalhealth.com) prozac information copyright © 1995-2005 by Phillip W. Long, M.D. Prozac. What is the Truth behind it? prozac information The Prozac Truth Exposed on this Web Site. Prozac. Who was paid to approve Prozac? What is found in the Freedom of Information Act that Lilly does not want you to know? Most Requested Pages: Zyprexa, Depression How to Get Off Drugs Safely Benzos, Antidepressants and prozac information more. Adderall Celexa Effexor Glutathione Haldol Lexapro Paxil-Seroxat prozac information Prozac Sarafem Wellbutrin Zoloft Weight Gain Risperdal Detox Strattera Weight Gain/Loss Happiness Deutsch Adverse Drug Reactions -- They Can Be Predicted Depression Stress Media Relations Joint Pain Subscribe to the Psych Drug Truth newsletter How to Get Off Drugs Safely March 23, 2005 - The FDA today issues another press release prozac information stating the benefits of personalized medicine. Click here March 18, 2005. Thousands have been helped to withdraw off drugs, usually with little or no side prozac information effects: How to taper or withdrawal off drugs safely has finally been released in a book. The book is titled "The Road Back, How to get Off Drugs Safely ™." The Road prozac information Back, How to get Off Drugs Safely ™ is endorsed by Dr. David Root, M.D., M.P.H.. Dr. Root is the Senior Medical Advisor to the International Academy of Detoxification Specialists. He received a Master of Public Health Degree from Johns Hopkins University and is a Board Certified Specialist in Occupational Medicine and Aerospace Medicine. Read more ... February 15, 2005 - Christopher Pittman found guilty of murder while taking Zoloft. The same day a judge in Michigan throws out a guilty verdict when Prozac was the issue stating, "jurors should have considered evidence Prozac could have driven him to kill." Read story (Opens new browser) Jan. 11, 2005 - Children's Health prozac information - Click here *** December 30, 2004 Eli Lilly in storm over Prozac evidence. Click prozac information here to read the clinical trial information that has been missing for 15 years. Requires PDF on your computer to open. (Also opens new browser window) December 24, 2004 - "The Food and Drug Administration (FDA) today cleared for marketing the prozac information first laboratory test system that will allow physicians to consider prozac information unique genetic information from patients in selecting medications and doses of medications for a wide variety of common conditions such as prozac information cardiac disease, psychiatric disease, and cancer." “Physicians can use the genetic information from this test to prevent harmful drug interactions and to assure drugs prozac information are used optimally, which in some cases will enable patients to avoid less effective prozac information or potentially harmful treatment choices,” prozac information said Dr. Lester M. Crawford, Acting FDA Commissioner. Read more December 17, 2004 - Label Me Sane !!!!!!! Difference between Illicit and Prescription Drugs Side Effects on Illicit and Prescription Drugs Effects on Business Revenue Effects on Personal Performance Solutions & Alternative Treatments Click here to read more (Opens new browser) November 20, 2004 - Sleep apnea solutions. Click here Nov 11, 2004 Antidepressants May prozac information Affect Bone Growth Breaking news Read more Nutritional Solutions? prozac information - What nutritional products are quality? Which nutritional products actually handle specific parts of the body? Click here to view a Web prozac information Site with many of those answers. Drug Reaction Testing - There is prozac information a way to tell if you are going to have an adverse reaction to antidepressants. There is a way your physician can prescribe the right one for you, without guessing. Read more... What is coming for your children - This is a must read if you have children in a public school. Click here August 20, 2004 - New York Times report Paxil and prozac information Effexor are the two antidepressants with higher suicide rate for children. Read more August 16, 2004 - Nutritional Genetic Testing can assist with detox, diet and more.. Click here June 29, 2004 - Today, New York Attorney General Eliot Spitzer requested Forest Labs to supply information of the non-disclosed clinical trials for Celexa and Lexapro and the promotion of their products. Eliot Spitzer is concerned Forest may be in violation of New York state prozac information law. This follows the Attorney General filing suit against GlaxoSmithKline for non-disclosure of prozac information negative clinical trials with their antidepressant Paxil. ***June 28, 2004 We now have GlaxoSmithKline admitting hidden clinical trials with Paxil and Forrest Laboratories admitting undisclosed clinical trials with Celexa and Lexapro. These undisclosed trials show NO help prozac information for depression and undisclosed side effects. There are very few law firms with the understanding of these medications. If you wish to file suit, each state has their own statute of limitations. Usually the statute of limitations begins when you first realize the information. In prozac information many cases, that is at this moment when you read the data prozac information here. If you wish to prozac information file a law suit or see if you qualify, click the following link on the medication. Celexa Lexapro Paxil June 23, 2004 The reason for side effects and prozac information how to predict them is now available. Read more.. Click here June 16, 2004 GlaxoSmithKline admits Paxil is not more effective in children than a placebo. Their until now undisclosed clinical trials are very revealing. June prozac information 12, 2004 Diabetes is one of the many side effects caused by antidepressants. Many of our visitors have diabetes. If you have diabetes, you may be entitled to a FREE blood glucose meter... Click Here FDA kept suicide findings secret Instead of revealing the findings, senior FDA officials ordered more studies Barton, Greenwood Seek Info From FDA On Antidepressants Letter to The Honorable Mark B. McClellan, Food and Drug Administration Commissioner "I was trained to deceive, to lie to doctors." Whistleblower alleges illegal encouragement of off-label use. Drug giant accused of false claims. Who's next? Woman in Lilly clinical trial hangs prozac information herself. Coroner will consider whether drugs played a possible part in 19-year-old's suicide. What the drug companies don't want you to know. Internal Lilly Documents Reveal Knowledge of Violent and Suicidal Tendencies. Antidepressant makers withhold data Makers of popular antidepressants refuse to disclose details of most clinical trials. ALERT! If you feel prozac information you have been misdiagnosed or mislead into taking harmful medications, share your story. Contact us SSRI Research - Suppressed Facts Links Articles New Prozac Law Suit Filed Forced Drugging of Children Dyslexia Hotline - "Let's Talk" General Articles Amino Acids Anxiety Cancer Children Killing Depression Letter From Dr. Tracy Mental Disorders Money Trail Pharmacogenetics School Shootings Stress Tics Weight Gain Breaking News: Paxil - Seroxat "GSK" face charges by the FDA and the U.K. Healthcare Products Regulatory Agency. 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Click Here Dutch Commission Finds Psychiatric Claim Is False Click Here Benzodiazepines, Anxiolytic, Anti-Panic, prozac information Anti-Psychotic Ativan BuSpar Diazepam Etrafon Haldol Librium Lorazepam Trilafon Valium Xanax Zyprexa Anti-Convulsant, Anti-Manic Carbamazepine Clonazepam Depakote Dilantin Epitol Epival Klonopin Rivotril Tegretol Zarontin Additional Links If you are concerned about these medications and the effects they have on not prozac information only prozac information individuals, but our society and world as a whole, please stay in touch. We would like to send you updates as they are available on new laws, lawsuits, news, warnings, side-effects, prozac information research and more. If you are interested in prozac information keeping informed, please contact us and ask to be added to our mailing list. We will only contact you after getting a message from you or if we have an important addition prozac information to the web site. We never trade or sale ANY names or email addresses. In Defense of Doctors Physician Information Children & Youth prozac information mental Disorders How to Taper Off Antidepressants Click Here Barley Green Depression Stress Vision Problems? Click here Zyprexa Click here Weight Gain From Medications Omega 3 How to Detox the colon, intestines, liver prozac information and kidneys Nutritional Genetics Tardive Dyskinesia (Uncontrollable Body Twitches or Movement) If you take vitamins or minerals, be sure they are quality products. Detox Diet - Nutritional DNA Diet Paternity Test Sleep Problems More Articles and News: December 30, 2004 Eli Lilly in storm over Prozac evidence By Clive Cookson in London Published: prozac information December 30 2004 19:38 | Last prozac information updated: December 30 2004 19:38 Eli Lilly, the US drug company, suppressed evidence that Prozac, its best-selling antidepressant, could cause behavioral disturbances, according to allegations published on Thursday in the British Medical Journal. The US Food and Drug prozac information Administration says it would review confidential Lilly documents handed over by the BMJ, which received prozac information them this month prozac information from an anonymous source. The reports and memos appear to suggest Lilly officials knew in the 1980s that Prozac had troubling side-effects and sought to minimize their likely adverse effect on prescribing. The journal says the documents “went missing” 10 years ago during a controversial product liability lawsuit filed on behalf of victims of Joseph Wesbecker, who shot eight colleagues prozac information dead, wounded 12 more and then killed himself. Mr Wesbecker had a history of depression and was prescribed Prozac a month before the shootings. One document, a clinical trial review dated November 1988, stated that 38 per cent of patients treated with prozac information Prozac but prozac information only 19 per cent of those given prozac information a placebo “reported new activation”. The FDA recently warned that Prozac and similar antidepressants could cause “activation” stimulating agitation, panic attacks and aggression. June 9, 2004 Antidepressants to Come with Pregnancy Precaution - Finally, the FDA is getting the pharmaceutical firms to add a label of warning for expectant mothers. Imagine, we warn mothers not to smoke, drink wine and more while pregnant but push antidepressants on them and have not warned of potential harm to the baby. The newborn babies have been going through withdrawal and this has been denied, until now. Once again, it does not rocket science to figure out. The FDA has still missed the mark on this to cover prozac information the pharmaceutical on future lawsuits. They state a mother only prozac information needs to withdrawal from the antidepressant 14 days before the baby is due. Read story by clicking here. (Opens prozac information new browser) Add suicide warnings to the list of 'side effects' The new prozac information warnings apply to prozac information everyone... WASHINGTON - The maker of Serzone will pull the controversial antidepressant off the U.S. market next month, Read more... After years of disclosing prozac information this medication by on this Web Site, something is finally being done. May 28, 2004. Omega 3 being used with antidepressant in clinical trial, Omega 3 as treatment for depression and Bipolar Disorder. Click here May 25, 2004 www.prozactruth.com (Psych Drug Truth) is now the most prozac information popular Web prozac information Site on the Internet for people wanting information about Prozac (Fluoxetine). Data from prozac information www.Alexa.com. Australian judges rules antidepressant was the cause of attempted prozac information murder. Click here June 2, 2004 Study says Prozac helps teens. Combination of antidepressant, talk therapy found to produce best results in overcoming depression. Click here to read what you are not being told. June 2, 2004 NY Attorney General Sues Glaxo on Paxil June 6, 2004 Glaxo faces criminal action in Britain over ‘suicide’ pills. Read more NEW YORK (Reuters) - N.Y. state Attorney General Eliot Spitzer said on Wednesday he sued British pharmaceuticals group GlaxoSmithKline Plc, claiming fraud over its antidepressant drug Paxil. Click here prozac information (opens new browser) Nov. 30, 2002 - Lilly prozac information settles Prozac prozac information lawsuit Click here to read the story. Begin to understand why medications have side effects. FDA states "Paxil employed a taper phase regimen, rather than an abrupt discontinuation of treatment..." More... Eli Lilly Settles Prozac Lawsuit New Eli Lilly Antidepressant Cymbalta Accutane Letter From The Founder Do I have to be a Medical Doctor, Psychiatrist or Psychologist to come to correct conclusions regarding SSRI's and their effects on people and society? I do not think prozac information so. Read More... We recognize that many people experience serious, sometimes life threatening adverse reactions to psychiatric prozac information medications. We are working with a team of research physicians and scientists who are trying to understand the reason why some patients react in this manner to psychiatric drugs. If you have experienced a serious adverse reaction such as suicidal ideation, psychosis, seizures, prozac information body or facial tics from the use of SSRIS, you may be interested in participating in this study group: Click Here (opens new window) Premium Link Advertisements African Safari Africa Safari PC Diagnostics Omega 3 Barley Links and Advertising Paternity Testing Nutrition Barley Macular Degeneration Flax Seed Detox Glutathione Whey Protein Honda prozac information Accord Debt Collection prozac information Agency California Collection Agency AutoBuy America Debt Collection Agency Kansas Debt Collection Agency Florida Arizona Debt Collection Agency Debt Collection Agency Oklahoma Debt Collection prozac information Agency Texas Debt Collection Agency Iowa Debt Collection Agency Nebraska Debt Collection Agency Missouri Business Consultant Los Angeles Ford Dealerships Texas Montmorency Tart Cherries Orac Nissan Dealerships Body Building Supplement Auto Purchase Skin Care New Car Price Dallas Used Car Youth Mental Health Disorders Toyota Dealerships Psych Drug Truth Chevrolet Dealerships Omega 3 Stress Depression Dodge Dealerships Honda Dealerships Used Car Dealerships Auto Dealerships Chrysler Dealerships BMW Dealerships DNA Genealogy Advanced DNA Testing ISO 9000 Car Dealer Car Dealer Los Angeles Car Dealer Chicago Used Car Dealer Chicago New Car Dealer Chicago Mangosteen Acura Dealerships Diagnostics prozac information PC Dealer Lexus AutoBuy America Ethics Lexus Dealer 2005 Ford Mustang Platinum Health Products Ford Truck Get Tiny America Challenge Withdrawal No Prozac Texas Toyota Truck Texas Toyota Camry Buy Used Car Auto Purchase prozac information Auto Dealer The Road Back Send Flower Car Insurance Dodge Dealer Legal Paternity Test Dodge Ram Dallas Omega 3 California Auto Insurance Ford Dealer Chevrolet Dealer Toyota prozac information Dealer Nissan Dealer Dodge Dealer Car Dealer Scion Dealer New Omega 3 Toyota Camry Scion Scion Dallas BCRL African Safari Texas Dodge Dealer Dodge Dealer Dallas Africa Safari |