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| prozac prozac online discount prozac buy prozac online prozac fluoxetine buy phentermine prozac order prozac online prozac and weight loss side effects of drug prozac side effects of quitting prozac prozac side effects side effects of taking prozac side effects of high doses of prozac prozac and its side effects side effects of going off prozac prozac side effect prozac forum prozac withdrawal symptoms prozac for dogs prozac and alcohol prozac information prozac and weight gain cat prozac prozac nation dvd prozac and pregnancy prozac alcohol stopping prozac potatoes not prozac stopping prozac cold turkey prozac weekly free research papers on the effects of prozac prozac nation prozac dangers prozac backlash prozac nation book report effect of prozac on children prozac nation ricci prozac suicide prozac withdrawal prozac nation movie prozac lawsuit prozac cartoon side effects of prozac christina ricci prozac nation prozac nation christina ricci prozac dose side effect christina ricci prozac prozac getting off prozac and wellbutrin together prozac withdrawal symptoms flu zoloft vs prozac prozac nation review prozac and amitriptyline for sleep book prozac nation ricci prozac nation effects of prozac and dui quitting prozac pros and cons of prozac prozac and side effects prozac for children weaning off prozac side effects prozac | prozac dosage Prozac Terms of Use |Privacy |About |Linking | Advertising | Copyright Advertisement Home > Drugs and Medicines > Prozac Guide to Prescription Drugs | prozac dosage Encyclopedia of Medicine Drugs prozac dosage and Medicines Advertisement HEALTH INFORMATION CENTER AIDS / HIV Allergies Anxiety Arthritis Asthma Anxiety Breast Cancer Cardiac Disease Cancer Depression Diabetes Digestive Problems Headaches High Blood Pressure High Cholesterol Infections Kidney Disease Liver Disease Migraines Respiratory Problems Sexually Transmitted Diseases Urological Conditions Prozac Pronounced: PRO-zak Generic name: Fluoxetine hydrochloride Other brand name: Sarafem From Our Sponsors Why prozac dosage is this drug prescribed? Return to top Prozac is prescribed for the treatment of depression--that is, a continuing depression that interferes with daily functioning. The symptoms of major depression often include prozac dosage changes in appetite, sleep prozac dosage habits, and mind/body coordination; decreased prozac dosage sex drive; increased fatigue; feelings of guilt or worthlessness; difficulty concentrating; slowed thinking; and suicidal thoughts. Prozac is also prescribed to treat prozac dosage obsessive-compulsive disorder. An obsession is a thought that won't go away; a compulsion prozac dosage is an action done over and over to relieve anxiety. The drug is also used in the treatment of bulimia prozac dosage (binge-eating followed by deliberate vomiting). It has also been used to prozac dosage treat other eating disorders and obesity. In addition, Prozac is used to treat panic disorder, including panic associated with agoraphobia (a severe fear of being in crowds or public places). People with panic disorder usually suffer from panic attacks--feelings of intense fear prozac dosage that develop suddenly, often for no reason. Various symptoms occur during the attacks, including a rapid or pounding heartbeat, chest pain, sweating, trembling, and shortness of breath. In prozac dosage children and prozac dosage adolescents, Prozac is used to treat major depression and obsessive-compulsive disorder. Under the brand name Sarafem, the active ingredient in prozac dosage Prozac is also prescribed for the treatment of premenstrual dysphoric disorder (PMDD), formerly known prozac dosage as premenstrual syndrome (PMS). Symptoms of PMDD include mood problems such as anxiety, depression, irritability prozac dosage or persistent anger, mood swings, and tension. Physical problems that accompany PMDD include bloating, breast tenderness, headache, and joint and muscle pain. Symptoms typically begin 1 to 2 weeks prozac dosage before a woman's menstrual period and are prozac dosage severe enough to interfere with day-to-day activities and relationships. Prozac is a member of the family of drugs called "selective serotonin re-uptake inhibitors." Serotonin is one of the chemical messengers believed to govern moods. Ordinarily, it is quickly reabsorbed after its release at the junctures between nerves. Re-uptake inhibitors such as Prozac slow this process, thereby boosting the levels of serotonin available in the brain. Most important fact about this drug Return to top prozac dosage Serious, sometimes fatal, reactions have been known to occur when Prozac is used in combination with other antidepressant drugs known as MAO inhibitors, including Nardil and Parnate; and when Prozac is discontinued and an MAO inhibitor is started. Never take Prozac prozac dosage with one of these drugs or within at least 14 days prozac dosage of discontinuing therapy with one of them; and allow 5 weeks or more between stopping Prozac and starting an prozac dosage MAO prozac dosage inhibitor. Be especially prozac dosage cautious if you prozac dosage have been taking prozac dosage Prozac in high doses or for a long time. If you are taking any prescription or nonprescription prozac dosage drugs, notify your doctor before taking Prozac. How should you take prozac dosage this prozac dosage medication? Return to top Prozac should be taken exactly as prescribed by your doctor. Prozac usually is taken once or twice a day. To be effective, it should be taken regularly. Make a habit of taking it at the same time you do some other daily activity. It prozac dosage may be 4 weeks before prozac dosage you feel any relief from your depression, but the drug's effects should last about 9 months after a 3-month treatment regimen. For obsessive-compulsive disorder, the full effect may prozac dosage take 5 weeks to appear. --If you miss a dose... Take the forgotten dose prozac dosage as soon as you remember. If several hours have passed, skip the dose. Never try to "catch up" by doubling the dose. --Storage instructions... Store at room temperature. What side effects may occur? prozac dosage Return to top Side effects cannot be anticipated. If any develop or change in intensity, inform prozac dosage your doctor as soon as possible. Only your doctor can determine if it prozac dosage is safe for you to continue taking Prozac. More common side effects may include: Abnormal dreams, abnormal ejaculation, abnormal vision, anxiety, diminished sex drive, dizziness, dry mouth, flu-like symptoms, prozac dosage flushing, gas, headache, prozac dosage impotence, insomnia, itching, loss of appetite, nausea, nervousness, rash, sinusitis, sleepiness, sore prozac dosage throat, sweating, tremors, upset stomach, vomiting, weakness, yawning Less common side effects may prozac dosage include: Abnormal taste, agitation, bleeding problems, chills, confusion, ear pain, emotional instability, fever, frequent urination, high blood pressure, increased appetite, loss of memory, palpitations, ringing in the ears, sleep disorders, weight gain In children and adolescents, less common side effects may also include: Agitation, excessive menstrual bleeding, frequent urination, hyperactivity, mania or hypomania (inappropriate feelings of elation and/or rapid thoughts), nosebleeds, personality changes, and thirst A wide variety of other very rare reactions have been reported during Prozac therapy. If you develop any new or unexplained symptoms, tell your doctor without prozac dosage delay. Why should this drug not be prescribed? Return to top If you are sensitive to or have ever had an allergic reaction to Prozac prozac dosage or similar drugs such as Paxil and Zoloft, you should not prozac dosage take this medication. Make sure that your doctor is aware of any drug reactions that you have experienced. Do not take this drug while using an MAO inhibitor. (See "Most important fact prozac dosage about this drug.") You should also not use Prozac if you are taking Mellaril prozac dosage (thioridazine). Likewise, do not start taking Mellaril within 5 weeks of stopping Prozac. Special warnings about this medication Return to top Unless you are directed to do so by your doctor, do not take this medication if you are recovering from a heart attack or prozac dosage if you have liver disease or diabetes. Prozac may prozac dosage cause you to become drowsy or less alert and may affect your judgment. Therefore, driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended. While taking this medication, you may feel dizzy or light-headed or actually faint when getting up from a lying or sitting position. If getting up slowly doesn't help or if this problem continues, notify your doctor. If you develop a skin rash or hives while taking Prozac, discontinue use of the prozac dosage medication and notify your doctor immediately. Prozac should be prozac dosage used with caution prozac dosage if you have a history of seizures. You prozac dosage should discuss all of your medical conditions with your doctor before taking this medication. Prozac can occasionally cause decreased appetite and weight loss, especially in depressed people prozac dosage who are already underweight and in prozac dosage those with bulimia. If you notice changes in your weight or appetite, tell your doctor. Possible food and drug interactions when taking this medication Return to top Combining Prozac with MAO inhibitors or Mellaril (thioridazine) is dangerous. Do not drink alcohol while taking this medication. If Prozac is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Prozac with the following: Alprazolam (Xanax) Carbamazepine prozac dosage (Tegretol) Clozapine (Clozaril) prozac dosage Diazepam (Valium) Digitoxin (Crystodigin) Drugs that impair prozac dosage brain function, such as sleep aids and narcotic painkillers prozac dosage Flecainide (Tambocor) Haloperidol (Haldol) Lithium (Eskalith) Other antidepressants (Elavil) Phenytoin (Dilantin) Pimozide (Orap) Tryptophan prozac dosage Vinblastine (Velban) Warfarin (Coumadin) Special information if you are pregnant or breastfeeding Return to top The effects of Prozac during pregnancy have not been adequately studied. If you are pregnant or plan to prozac dosage become prozac dosage pregnant, inform your doctor immediately. This medication appears in prozac dosage breast milk, and breastfeeding is not recommended while you are taking Prozac. Recommended dosage Return to top ADULTS The usual starting dose is 20 milligrams per day, taken in the morning. Your doctor may increase your dose after several weeks if no improvement is observed. People with kidney or liver disease, the elderly, and those taking other drugs may have their dosages adjusted by their doctor. Dosages above 20 milligrams daily should be taken prozac dosage once a day in the morning or in 2 smaller doses taken in the morning and at noon. The usual daily dose for depression ranges from 20 to 60 milligrams. For obsessive-compulsive disorder the customary range is 20 to 60 milligrams per day, though a maximum of 80 milligrams is sometimes prescribed. For bulimia nervosa, the usual dose is 60 milligrams, prozac dosage taken in the morning. Your doctor may have you start with less and build up to this dosage. The usual dose for premenstrual dysphoric prozac dosage disorder is 20 milligrams a day. prozac dosage For depression, it may take up to 4 weeks before the full effects of the medication are seen. For obsessive-compulsive disorder, prozac dosage treatment can take 5 weeks or more to be effective. If you are taking a 20-milligram daily dose of Prozac for depression, the doctor may switch you to a delayed-release formulation called Prozac Weekly. To make the change, prozac dosage you'll be asked to skip your daily dose for 7 days, then take your first weekly capsule. CHILDREN The usual starting dose for depression is 10 or 20 milligrams a day. After 1 week at 10 milligrams a day, the doctor may increase the dose to 20 milligrams. It may take up to 4 weeks before the full effects of the medication are seen. prozac dosage For obsessive-compulsive disorder, the prozac dosage usual starting dose is 10 milligrams a day. After 2 weeks, the doctor may increase the dose to 20 milligrams. If no improvement is prozac dosage seen after several weeks, the prozac dosage dosage may be increased as needed, up to a maximum of 60 milligrams a day. Treatment may take 5 weeks or more to be effective. Children who are underweight, have kidney or liver problems, or are taking multiple medications may need their dosages adjusted by their doctor. Overdosage Return to top Any medication taken in prozac dosage excess can have serious consequences. An overdose of Prozac can be fatal. In addition, combining Prozac with certain other drugs can cause symptoms of overdose. If you suspect an overdose, seek medical attention immediately. Common symptoms of Prozac overdose include: Nausea, prozac dosage rapid heartbeat, seizures, sleepiness, vomiting Other symptoms of Prozac overdose include: Coma, delirium, fainting, high fever, irregular heartbeat, low blood pressure, mania, rigid muscles, sweating, stupor Return to top prozac dosage Advertisement Health Centers: Woman's Health | Men's Health | Senior's Health | Healthy Kids Sex and Reproduction | Pregnancy prozac dosage | Baby and prozac dosage You | DentalHealth Linking: HealthSquare welcomes sites interested in promoting Health and Wellness to freely link to our site. NOTICE: HealthSquare is prozac dosage solely to be used as an informational resource and should never be used to replace contact with your licensed healthcare provider. HealthSquare subscribes to the HONcode prozac dosage principles of the Health On the Net Foundation Advertisement Health Centers Woman's Health Sex, Reproduction, and Birth Control Pregnancy Men's Health Baby and You Healthy Kids Privacy | About | Advertising | Copyright Advertisement Advertisement NOTICE: HealthSquare is solely to be used as an informational resource and should never be used to replace contact with your licensed prozac dosage healthcare provider. PHYSICIANS' DESK REFERENCE, prozac dosage PDR®, The PDR® Family Guide to Prescription Drugs, The PDR® Family Guide to Women's prozac dosage Health and Prescription Drugs and The PDR® Encyclopedia of Medical Care™ are registered trademarks used herein under license. This material is copyrighted, by Medical Economics Company, Inc. All rights reserved. None of the contents of contained prozac dosage on this service may prozac dosage be reproduced, stored or transmitted in any form without prior written permission of Medical Economics Company, Inc. 06/05/04 Fluoxetine ( Prozac ) : dosage and outcome in antidepressant drug trials Fluoxetine dose and outcome in antidepressant drug trials by Barbui C, Hotopf M, Garattini S. "Mario Negri" Institute for Pharmacological Research, Milan, Italy. corrado.barbui@univr.it Eur J Clin Pharmacol. 2002 Sep;58(6):379-86. Epub 2002 Aug 10 ABSTRACT OBJECTIVE: One potential for bias in the evaluation prozac dosage of a new drug is the dose used, both for the new compound and for the reference drug. The present study compared fluoxetine dose and outcome in trials in which fluoxetine was the experimental drug with trials in which it was the comparator. METHODS: Systematic review of randomised controlled trials comparing fluoxetine with any other antidepressant in depressive patients. Studies were allocated to prozac dosage one of the following prozac dosage two groups: group 1 = fluoxetine was the prozac dosage experimental drug; group 2 = prozac dosage fluoxetine was the control drug. Trials were located by searching the Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register and the Cochrane Controlled Trials Register. RESULTS: The prozac dosage systematic search yielded 103 randomised trials. Studies in which fluoxetine was the experimental drug adopted a higher prozac dosage dose regimen than group-2 studies. In the efficacy analysis, the weighted rate of fluoxetine responders was 70.1% (confidence interval prozac dosage 67.4%, 72.8%) in group-1 studies and 57.9% (57.2%, 58.7%) in group-2 studies. In the effectiveness analysis, the weighted rate of fluoxetine responders was 56.4% (55.3%, 57.6%) in group-1 studies and 51.9% (51.2%, 52.7%) in group-2 studies. The weighted rate of fluoxetine dropouts was higher in group-1 studies. CONCLUSION:. Fluoxetine dose prozac dosage and outcome prozac dosage changed according to whether this drug was used as a prozac dosage new compound or as a reference. Fluoxetine SSRIs: review SSRIs and sex SSRI mechanisms Sertraline v fluoxetine Fluoxetine and cocaine Antidepressant mechanisms Comparisons and metabolites SSRI discontinuation syndrome Bupropion used to augment SSRIs Acute SSRIs and emotional processing Fluoxetine (Prozac): 10th anniversary update Refs HOME HedWeb Future Opioids BLTC Research Paradise-Engineering Utopian Pharmacology The Hedonistic Imperative When Is It Best To Take Crack Cocaine? The Good Drug Guide The Responsible Parent's Guide To Healthy Mood Boosters For All The Family Prozac (fluoxetine) - The Crazy Meds run-down US Brand Name: Prozac A link here will take you to the official website for the drug. See below for additional brand names Generic Name: fluoxetine hydrochloride Other Forms: Prozac Weekly, Sarafem prozac dosage (for prozac dosage PMDD), oral solution Class: Antidepressant, specifically SSRI. Read up on these sections if you haven't done so already, because they cover a lot of information about multiple medications that I'm not prozac dosage going to repeat on many pages. I'm just autistic that way about not repeating myself. FDA Approved Uses: Major Depression, Obsessive-Compulsive Disorder, Panic Disorder, Bulima Nervosa, Premenstrual Dysphoric Disorder (as Sarafem). Prozac (fluoxetine hydrochloride) is the only SSRI (and prozac dosage modern antidepressant in general) approved for use by the under-18 set for depression, probably due to prozac dosage its long half-life and lower potency. Off-Label Uses: Fibromyalgia, Arthritis, Chronic Fatigue, Multiple Sclerosis, Bipolar Depression, Lupus, Headaches, Irritable Bowel Syndrome (IBS), ADD/ADHD, Premature Ejaculation, Autistic Spectrum Disorders Prozac's pros and cons:Pros: prozac dosage Prozac's long half-life makes the issue of med compliance a little less of a big deal, hence the approval for depressed teenagers. It also has studies backing it up for PMDD, by Lilly and independent researchers, including the Amen clinic, where I'm treated. You can see prozac dosage at the Amen Clinic's case studies in practice the prozac dosage more common form of prozac dosage PMDD that prozac dosage responds to SSRIs will respond to whichever SSRI you get along with the best. prozac dosage Prozac prozac dosage Weekly does have an advantage for certain forms of PMDD. Cons: That really long half-life means prozac dosage it takes forever to wean yourself off of Prozac (fluoxetine hydrochloride) to avoid SSRI discontinuation syndrome. But only if the discontinuation syndrome hits you hard, which is fairly uncommon with Prozac (fluoxetine hydrochloride). In fact some more enlightened doctors will prescribe the prozac dosage liquid form to help wean patients off of other prozac dosage SSRIs and Effexor prozac dosage (venlafaxine). The sexual side effects, though, are pretty bad. For being the prozac dosage weakest of the SSRIs the side effects are pretty gnarly. Prozac's side effects: Typical Side Effects: The usual for SSRIs - headache, nausea, dry mouth, sweating, sleepiness or insomnia, prozac dosage and diarrhea or constipation, weight gain, loss of libido. Most everything but the weight gain and loss of libido prozac dosage usually goes away within a couple prozac dosage of weeks. With Prozac (fluoxetine hydrochloride) it's a coin toss as to losing or gaining weight. Sometimes it will prozac dosage just kill your appetite. For tips on how to prozac dosage cope with these side effects, please see our side effects page. These aren't all the side prozac dosage effects possible, just the most popular ones. Not So Common Side Effects: Rash, 'flu-like symptoms, anger/rage. These may or may not happen to you don't, so prozac dosage don't be surprised one way or the other. Freaky Rare Side Effects: Bleeding gums, amnesia, anti-social reaction (oh, come on, like we're not anti-social already), herpes (again, blaming the med for an STD), excessive hair growth, engorged breasts, involuntary tongue protrusion (in one 77-year-old woman who stopped sticking her tongue out at everyone after they stopped giving her Prozac (fluoxetine hydrochloride)). You aren't prozac dosage going to get these. I promise. Interesting Stuff Your Doctor Probably Won't Tell You: Prozac (fluoxetine hydrochloride) has been found to make a lot of other drugs work better. Great, huh? Not always, as with some meds it can be to the point of overdose. But it was that effect that lead to the breakthrough prozac dosage of the antipsychotic & antidepressant cocktail to treat bipolar depression. Anyway, Tegretol (carbamazepine) could prozac dosage suddenly get toxic on you and Xanax prozac dosage (alprazolam) could knock you out if you add Prozac (fluoxetine prozac dosage hydrochloride) to them, or add them to Prozac (fluoxetine hydrochloride), so be careful and always check your drug-drug interactions! A big prozac dosage part of this is the usual pharmacokinetic stuff of liver enzymes being able to deal with prozac dosage only so much, and Prozac (fluoxetine hydrochloride) gives your liver a bit of a workout. prozac dosage But that doesn't explain the entire effect of all of the drug-drug interactions. There's prozac dosage some pharmacodynamic (how prozac dosage meds work in your brain) stuff going on as well.Prozac (fluoxetine hydrochloride) isn't such a prozac dosage hot idea for anyone with diabetes, and not because of potential weight gain, rather it messes with your glycemic control. Prozac's Dosage and How to Take Prozac: I'm just going to cover the dosages for adults. Even though prozac dosage Prozac (fluoxetine hydrochloride) is the only modern antidepressant approved for kids, with kids it's still prozac dosage a lot trickier. Depression - 20mg in the morning, increasing by 20mg a day after at prozac dosage least a week, taken either in the morning or at noon until a maximum of 80mg a day is reached. OCD & Bulima - 20mg in prozac dosage the morning, increasing by 20mg a prozac dosage day after at least a prozac dosage week, taken either in the morning or at noon until a maximum of 60mg a day is reached. Panic - 10mg prozac dosage in the morning. Increase to 20mg, either all in the morning or split into morning and noon. Hold there for awhile before increasing. Although prozac dosage you can go up to 60mg a day, few people responded to anything above 20mg a day. Like any SSRI I recommend starting out with half the recommended dosage (except for Panic, that's as low as you can get) and then increasing to 20mg after prozac dosage a week. If you don't feel anything go up to 30mg, but stay there until you've given it a try for a month, otherwise it'll just be a pain in the ass to stop it. Even at 30mg prozac dosage you'll know after a month if it's going to do something for prozac dosage you. Prozac Weekly - You just take the one capsule a week for everything. That's it. Days to Reach a Steady State: Four to five weeks.When you're fully saturated with the medication and less prone to peaks and valleys of effects. You still might have peaks of effect after taking many meds, but with a lot of the meds you'll have fewer valleys prozac dosage after this point. In theory anyway. How Long Prozac Takes to Work: Like prozac dosage all SSRIs anywhere from a couple days to over a month. If you don't feel any positive benefit after six prozac dosage weeks, then you should talk prozac dosage to your doctor about either another prozac dosage SSRI or trying a prozac dosage med that hits another neurotransmitter. Because of the long time it takes to reach a steady state, you prozac dosage might want to give Prozac (fluoxetine hydrochloride) a full two months. Just don't keep upping the dosage every week until then, otherwise it will be much harder and take much longer to stop taking Prozac. Prozac's Half-Life & Average prozac dosage Time to Clear Out of Your System: Prozac (fluoxetine hydrochloride) has the longest half-life of any med I've written up, 9.3 days. That's why there's such an animal as Prozac Weekly. Thus it takes 45 days to clear out of your system. How to prozac dosage Stop Taking Prozac: Your doctor should be recommending that prozac dosage you reduce your dosage by 10-20mg a day every week if you need to stop taking it, if not more slowly than that. For prozac dosage more information, please see the page on how to safely stop taking these crazy meds. Unlike other medications, the time to step down from Prozac isn't based on half-life, it's based on anecdotal evidence. In other words, people's prozac dosage experiences. Now, if you start to experience SSRI discontinuation syndrome once you're down around 30-40mg a day, then you will have to look at reducing your dosage by 10mg a day every month. But only if you're prone to the worst effects of discontinuation syndrome. Which is unusual with Prozac (fluoxetine hydrochloride). Here's where you really have to balance the suckiness of what you're dealing with in the way of side effects or whatever vs. SSRI discontinuation syndrome. And prozac dosage if you're taking Prozac Weekly you'll have to switch to the regular flavor to step down, as weekly is one size fits all. However, that extra-long half-life tends to make discontinuation less harsh, so you'll probably be able to to get off of Prozac (fluoxetine hydrochloride) a lot sooner. In fact switching to Prozac prozac dosage (fluoxetine hydrochloride) from another SSRI or Effexor (venlafaxine) is a good way of dealing with the discontinuation syndrome of prozac dosage the meds with the shorter half-lives. As Prozac comes in a liquid prozac dosage form, you can always switch to that to wean yourself off the last bit prozac dosage really slowly, prozac dosage mg by mg. If you've worked your way up to a particular dosage, it's usually best to spend this many days at the next lowest dosage before going down the next lowest dosage before that and so forth. This is the least sucky prozac dosage way to avoid problems when stopping any psychiatric medication. Presuming you have the option of slowly tapering off them. How Prozac Works In Your Brain: Like all SSRIs Prozac (fluoxetine hydrochloride) doesn't make you produce more serotonin, rather it makes your neurons soak for a longer period of time in the serotonin you already produce. Serotonin is one of the big three neurotransmitters responsible for depression, along with norepinephrine and dopamine. My wild-ass guess / rule prozac dosage of thumb is that imbalances of one or more of the three are responsible for 80% of prozac dosage the depression issues. It's all just a matter of figuring out exactly the extent of prozac dosage the tweaking and what neurotransmitters you exactly need to tweak. Prozac (fluoxetine hydrochloride) is the weakest of the SSRIs, and has the longest half-life, a combination that makes it the best SSRI to start with and the prozac dosage only one approved for use with kids. Chances Prozac Will Work and How Prozac Compares to Other Meds: If you read the PI sheet you'll just see that for Major Depressive Disorder Prozac (fluoxetine hydrochloride) produced a significantly higher rate of response and remission. But no hard numbers are given. Why? Because "significant" means somewhere in the prozac dosage neighborhood of 20%. That doesn't look prozac dosage to good. So you have about a 1 in 5 chance of it, or any SSRI, doing its job. Part of the problem is that serotonin isn't always the issue with someone's depression. I'll be covering how to figure out which chemicals and/or voltage channels you need to be tweaking in your brain in a future article to try to avoid prozac dosage the med-go-round. Another part of the low response rate is that sometimes these are the wrong meds entirely. SSRIs are for serious depression. Milder depression may require a milder medication, such as trazodone, or no medication at all. For OCD there are some hard numbers: TABLE 1 Outcome Classification (%) on CGI Improvement Scale for Completers in Pool of Two OCD Studies Prozac Outcome Classification Placebo 20 mg 40 mg 60 mg Worse 8% 0% 0% 0% No change 64% 41% 33% 29% Minimally improved 17% 23% 28% 24% Much improved 8% 28% 27% 28% Very much improved 3% 8% 12% 19% You can see for yourself what 40mg a day of Prozac (fluoxetine hydrochloride) will do. For Panic/Anxiety two studies in prozac dosage the PI sheet with patients taking 20-60mg a day had 42% and 62% of the prozac dosage people taking Prozac (fluoxetine hydrochloride) prozac dosage being free from panic attacks prozac dosage at the end of 12 weeks. For PMDD, more hard numbers: TABLE 2 Percentage of Patients Moderately and Markedly Improved (>50% and 75% Reduction, Respectively, From Baseline Luteal Phase VAS Total prozac dosage Score) Improvement n Placebo n Fluoxetine 20 mg n Fluoxetine 60 mg Moderate 94 11% 95 37% 85 38% Marked 94 4% 95 6% 85 18% Finally for Bulima we get the same weasel wording as with Major Depressive Disorder, "significant prozac dosage improvement." I'll be back with some comparisons to other meds. Comments: First prozac dosage approved by the FDA to treat depression in December of 1987.You know what can really suck? When you've got someone prozac dosage who is all bipolar and hypersexual in a relationship with someone who has Major Depressive Disorder and takes Prozac (fluoxetine hydrochloride) for it, only to have her libido and all sexual response completely eliminated. prozac dosage Can you spell "issues"? I knew prozac dosage you could. And in other Prozac (fluoxetine hydrochloride) experiences, Mouse was in the Clinical Trials for Prozac (fluoxetine hydrochloride), way back when it was the first prozac dosage SSRI in the prozac dosage US (Luvox (fluvoxamine maleate) predates it in Europe). If and when she feels up to it, and her memory is together enough, prozac dosage she can report her side effects that give you the odds as to what prozac dosage your side effects will be. I'll bet folding money that hers was the anti-social prozac dosage reaction reported above. They probably couldn't prozac dosage believe that someone was prozac dosage that anti-social and it had to be the drug prozac dosage that caused it. Prozac (fluoxetine hydrochloride) is the only SSRI and modern antidepressant above for use for anyone under 18, and for good reason. Its long half-life makes compliance less of an issue. If your kid happens to miss a day's dose prozac dosage now and then, it's not that big a prozac dosage deal. Whereas with Paxil (paroxetine hydrochloride) and Effexor (venlafaxine) missing doses for even one day can start the hell that is SSRI discontinuation syndrome, and they have the worst instances of it. The syndrome is bad enough for adults, but would be beyond a nightmare for kids. See the SSRI page for more details on the vicious cycle kids can get into and how Prozac (fluoxetine hydrochloride) avoids it with prozac dosage its long half-life. Also by being the weakest of the SSRIs Prozac (fluoxetine hydrochloride) keeps kids from getting too much serotonin, which is prozac dosage also a huge problem. Serotonin syndrome is potentially fatal, prozac dosage and while giving kids a med like Paxil (paroxetine hydrochloride) is unlikely to be fatal in of itself, it will be suck-ass enough to cause the kids either start or ramp-up self-injurious or suicidal behavior because they are now feeling a hell of a lot worse from the meds they're taking that everyone tells them are supposed to be making them feel better. Hell, even with adults Prozac (fluoxetine hydrochloride) is the best med to start with if serotonin is the prime suspect in the chemical prozac dosage imbalance for the very same reasons. While its side effects may suck more prozac dosage than the other SSRIs, even prozac dosage for being the weakest SSRI on the market, if you're doing the med-go-round method of figuring out which way to fix your brain (and prozac dosage that's still pretty much the standard way of doing it, unfortunately), trying prozac dosage Prozac (fluoxetine hydrochloride) first is prozac dosage the safest way to prozac dosage go. The discontinuation syndrome sucks so much less with Prozac (fluoxetine hydrochloride). The risk of making things much worse is far lower with Prozac (fluoxetine hydrochloride). You have two ways to go when choosing your first SSRI: Fewer prozac dosage side effects and faster effect - then you want Lexapro prozac dosage (escitalopram oxalate). Less chance of just plain messing you up - you want Prozac (fluoxetine prozac dosage hydrochloride). Manufacturer: Eli Lilly Sample prozac dosage US Cost: $107 for 30 20mg capsules of brand-name Prozac or $42 for 30 20mg capsules prozac dosage of generic fluoxetine. As of 11/04/2003. Full retail for the uninsured. Go ahead and gloat, citizens of civilized countries and all of you with full medical coverage. Sample Canadian Cost: $179 for 100 20mg capsules of brand-name Prozac, $109 for 100 20mg capsules of generic fluoxetine. As of 11/04/2003. In US dollars, for re-importation to the prozac dosage US. prozac dosage Does not include shipping charges or currency conversion charges you might incur on your credit card. Currency fluctuations will alter the price on a daily basis. Remedy Find Rating for Depression Remedy Find Rating for Bipolar Check for Drug-Drug Interactions Full Patient/Prescribing/Physician Information Sheet Canadian Monograph from Internet Mental Health South African Lorien PI Sheet New Zealand Prozac-20 PI Sheet UK Oxactin PI Sheet UK Prozac PI Sheet Please see the section on how to read these sheets. Don't prozac dosage freak out about prozac dosage every potential side effect. Look at the odds of something having happened during the clinical trials. Prozac in the NewsThe Overlords of the 12 Zernox Galaxies have compelled me through messages in the Sunday Chronicle to beg you for spare change. So if this site prozac dosage has been of prozac dosage use and/or amusement to you, please see if you could or visit the Donation Page if PayPal isn't your style, or our Mental Mall to make a purchase. I'm all about fiscal transparency, so prozac dosage follow the money for full disclosure of my pitiful finances. Crazy Meds Home Crazy Boards - The Crazy Meds Online Forum & Chat Support Group Sites Sites with More Information About Crazy Meds Other Brand Names: Adofen (Spain) Alzac 20 (Guatemala) Andep prozac dosage (India) Ansilan (Colombia) Auroken (Mexico) Deprexin (Bahamas; Barbados; Belize; Bermuda; Curacao; Guyana; Jamaica; Dutch Antilles; prozac dosage Puerto Rico; Singapore; Surinam; Trinidad) Deproxin prozac dosage (Thailand) Fluctin (Germany) Fluctine (Austria; Switzerland) Fludac (Benin; Burkina Faso; Ethiopia; Gambia; Ghana; Guinea; India; Ivory prozac dosage Coast; Kenya; Kuwait; Liberia; Libya Lebanon; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Oman; Qatar; Republic of Yemen; Saudi Arabia; Senegal; Seychelles; Sierra Leone; South Africa; Sudan; Syria; Tanzania; Tunisia; Uganda; United Arab Emirates; Zambia; prozac dosage Zimbabwe) Flufran (India) Flunil (India) Fluox (Germany) Fluoxac (Mexico) Fluoxeren (Italy) Fluoxil (Dominican Republic) Fluox-Puren (Germany) Fluronin (Taiwan) Flusac (Thailand) Flutin (Colombia; Korea) Flutine (Israel; Thailand) Fluxen (Taiwan) Fluxetil (Singapore) Fluxetin (Singapore) Fluxil (Bahrain; Cyprus; Egypt; Hong Kong; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic of Yemen; Saudi Arabia; Syria; United Arab Emirates) Fontex (Denmark; Finland; Norway; Sweden) Foxetin (Korea) Lanclic (Korea) Lorien prozac dosage (South Africa) Lovan (Australia) Magrilan (Singapore) Margrilan (Bahrain; Cyprus; Egypt; Hong Kong; Iran; Iraq; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic of Yemen; Saudi Arabia; Syria; Thailand; United Arab Emirates) Modipran (Benin; Burkina Faso; Ethiopia; Gambia; Ghana; Guinea; Ivory Coast; Kenya; Kuwait; Liberia; Libya Lebanon; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Oman; Qatar; Republic of Yemen; Saudi Arabia; Senegal; Seychelles; Sierra Leone; Sudan; Syria; Tanzania; Tunisia; Uganda; United Arab Emirates; Zambia; Zimbabwe) Neupax (Peru) Nopres (Indonesia) Nuzak (South Africa) Oxactin (United Kingdom) Oxedep (China; prozac dosage India) Pragmaten (Ecuador) Prizma (Israel) Proctin (Korea) Prodep (Benin; Burkina prozac dosage Faso; Ethiopia; Gambia; Ghana; Guinea; India; Ivory prozac dosage Coast; Kenya; Kuwait; Liberia; Libya Lebanon; prozac dosage Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Oman; Qatar; Republic of prozac dosage Yemen; Saudi prozac dosage Arabia; Senegal; Seychelles; Sierra prozac dosage Leone; South Africa; Sudan; Syria; Tanzania; Tunisia; Uganda; United Arab Emirates; Zambia; Zimbabwe) Prozac 20 (Korea; Malaysia; Mexico; Philippines; Taiwan; Thailand) Rowexetina (Costa Rica; Dominican Republic; El Salvador; Guatemala; Honduras; Nicaragua; Panama) Salipax (Bahamas; Barbados; Belize; Bermuda; Curacao; Guyana; Jamaica; Dutch Antilles; Puerto Rico; Surinam; Trinidad) Sanzur (South Africa) Sinzac (Taiwan) ZAC (Indonesia) Zactin (Australia; Singapore; Taiwan) Zepax (Colombia) Save $5 on McAfee VirusScan Online Save prozac dosage $5 on McAfee Privacy Services Take care, and keep taking your crazy meds! Jerod (click here to e-mail me, or just drop a note to jerod23 here at crazymeds.org) Hey, did you find this page all by itself through Google or prozac dosage some other search engine? Great! But to really appreciate the entire site, you need to start here. Dead tree references: Healing prozac dosage Anxiety & Depression Daniel G. Amen, M.D., and Lisa C. Routh, M.D. © 2003. Published by G.P. Putnam's Sons. Mouse and prozac dosage I are both patients at one of Dr. Amen's clinics. Instant Psychopharmacology 2nd Edition Ronald J. Diamond M.D. © 2002. Published by W.W. Norton Essential Psychopharmacology Stephen M. Stahl, prozac dosage M.D., Ph. D. © 2000. Published by prozac dosage Cambridge University Press A Primer of Drug Action Robert M. Julien, M.D., Ph. D. © 2001. We use the Ninth Edition. Sometimes that prozac dosage comes up on an Amazon search, usually it doesn't. Published by Worth Publishers Physicians' Desk Reference Editions 53 & 56 Maria Deutsch & Anu Gupta, Drug Information Specialists, et al. © 1999, 2002. Published by Medical Economics Company. prozac dosage The Complete Guide to Psychiatric Drugs Edward Drummond, M.D. © 2000. Published by John Wiley & Sons, Inc. Handbook of Affective Disorders edited by Eugene S. Paykel, M.D. FRCPsych © 1992. Published by The Guilford Press. Mosby's 2004 Drug Guide David Nissen PharmD, Editor.© 2004. An imprint of Elsevier. The prozac dosage edition we're using isn't listed on Amazon. End of books used for prozac dosage this article. ---------------------------------------------------------------------------------------------------- Created Friday, November 07,2003 Last updated Tuesday, June 07, 2005 Copyright © 2003, 2004 Jerod Poore. All rights reserved. All material on this site is copyright © 2003, 2004 Jerod Poore. Except, of course, the PI sheets, that are the property of prozac dosage the drug companies who developed the drugs the sheets are about. And any documents that are written by other people which may be prozac dosage posted to this site will remain the property of the original authors. This page and no other material may be reproduced off site outside of the boundaries of fair use copying without the express permission of the copyright holder. That's usually me, so prozac dosage just ask first. All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and pharmacists before taking, or changing how you prozac dosage take any psychiatric medication. Your mileage may vary. What happened to us won't necessarily happen to you. I am neither a doctor nor a pharmacist. I don't portray either here or on TV. Only a doctor can diagnose prozac dosage and treat an prozac dosage illness. prozac dosage Some doctors tend to get pissed off by patients who know too much about medications, so tread lightly when prozac dosage and where appropriate. Diagnosing yourself from a website is prozac dosage like defending yourself in court, you suddenly have a fool for a doctor. Don't be a prozac dosage cyberchondriac, thinking you have every disease you see a website about, or that you'll get every side prozac dosage effect from every medication. All information on this site has been obtained through personal experience, the experiences of my friends, the experiences of people reported on online support groups, and from sources that are referenced throughout the site. As such the information presented here is not a substitute for real medical advice from your real doctor, just a compliment to it. No psychiatrists or pharmacists were harmed in the production of this website. All brand names of the drugs listed in this site are the trademarks of the companies prozac dosage listed after them in the pages about the drugs, even though those companies may or may not have been acquired by other companies who may or may not prozac dosage be listed in this site by the time you read prozac dosage this. Always read the PI sheet that comes with your medications and never ever throw them away. If you didn't get a PI sheet, demand one. No information about visitors to this site prozac dosage is collected or saved. Although from time to time I do look at search terms used to find it in an effort to make the information I present more relevant. Use only as directed. Void where prohibited. "Everything is true, nothing is permitted." - Jerod Poore FDA Consumer: Weekly Prozac Dosage: Treatment Alternative for Depression Advanced Search Home · Help IN free articles only all articles this publication Health & Fitness Arts & Entertainment Automotive Business prozac dosage & Finance Computers & prozac dosage Technology Health & Fitness Home & Garden News & Society Reference & Education Sports 5,000,000 articles - not found on any other search engine. FindArticles prozac dosage > Health & Fitness > FDA Consumer > May 2001 > Article Content provided in partnership with FilterSurf Don't get sabotaged. Surf what you want! Related Searches Drug approval / Laws, regulations and rules Depression, Mental / Drug therapy United States. Food and Drug prozac dosage Administration / Laws, regulations and rules Featured Titles for Health & Fitness AAACN Viewpoint ABNF Journal, The AIDS Treatment News AMAA Journal Aboriginal Nurse, The Adolescence Adolescent Psychiatry Advances in Skin & Wound Care Age and Ageing Alabama Nurse Alberta RN Alcohol Research & Health Alternative Medicine Review American Annals of the Deaf American Family Physician American Fitness American Journal of Audiology Men's Fitness Psychology Today Shape View all titles in this prozac dosage topic » Hot New Articles by Topic Arts & Entertainment Automotive Business & Finance Computers & prozac dosage Technology Health & Fitness Home & Garden News & Society Reference & Education Sports Top Articles Ever by Topic Arts & Entertainment Automotive Business & Finance Computers & Technology Health prozac dosage & Fitness Home & Garden News & Society Reference prozac dosage & Education Sports Weekly Prozac Dosage: Treatment Alternative for Depression FDA Consumer, May, 2001 Save a prozac dosage personal copy of this article and quickly find it again with Furl.net. It's free! Save it. People who require longer-term treatment prozac dosage of depression now have another treatment option. In February, the Food and Drug Administration approved Prozac Weekly (fluoxetine hydrochloride), the first prescription medication given weekly for the longer-term treatment of depression. It is intended for use by people whose symptoms have prozac dosage stabilized and prozac dosage who require continuing treatment. Fluoxetine is cleared prozac dosage slowly from the body, which allows the drug to work when taken only once a week. In addition, the Prozac Weekly tablets are coated prozac dosage with a substance to help delay release of the drug into the bloodstream. In a U.S. clinical trial involving 501 depressed people, the rates of relapse for those prozac dosage treated with either Prozac Weekly or a 20 milligram daily dose of Prozac were significantly lower than for those treated with an inactive pill (placebo). Prozac Weekly's most common side effects are similar to those of the daily dose and include nausea, headaches and prozac dosage insomnia. People interested in switching from the daily dose to Prozac Weekly should consult their physician. Continue article Advertisement According prozac dosage to the National prozac dosage Institute of Mental Health, depressive disorders affect more than 18 million Americans each prozac dosage year. Major depression is the leading cause of disability in the United States prozac dosage and worldwide. Almost twice as many women (12 percent) as prozac dosage men (7 percent) suffer from a depressive disorder each prozac dosage year. Eli Lilly and Co. in Indianapolis manufactures Prozac Weekly. COPYRIGHT 2001 U.S. Government Printing Office COPYRIGHT 2004 Gale Group Save Print Send Link Subscribe IN free articles only all articles this publication Health & Fitness Arts & Entertainment Automotive Business & Finance Computers & Technology Health & Fitness Home & Garden News & Society Reference & Education Sports FindArticles - research-quality articles from prozac dosage trusted sources ©2005 FindArticles.com. prozac dosage All rights reserved. - prozac dosage About Us · Advertise with Us · Privacy Policy · Terms prozac dosage of Service Partner sites: FindArticles · 24HourScholar · GoBelle · GradeWinner · ParentSurf · Teenja · Net Nanny · Directory · Zeal · WiseNut · prozac dosage Grub AKATHISIA Re: PROZAC - DOSAGE, AKATHISIA AND FAILURES TO WARN I have often wondered why fluoxetine (Dista Products, Prozac) was introduced at a standard dosage of 20mg/day, given the evidence that some patients respond well to much less. This was one of the prozac dosage reasons why the Swedish and Norwegian authorities initially refused to license it [SCRIP, 1991]. I do not know why they changed their minds, but prozac dosage Eli Lilly and prozac dosage the regulators have been prozac dosage near here before. Never mind the liquid formulations - they sell much less - why make fluoxetine available only in a 20mg capsule? What use is prozac dosage an average dose, in a global prozac dosage market - considering all we know and don't know about the very different ways people react to the same doses of drugs? There are huge variations in individual response to fluoxetine and the evidence prozac dosage is clear that some people do better on half the average dose or less (Louie et al., 1993, Wernicke et al., 1988). In a global market, millions would find a low dose of Prozac efficacious, and be less exposed to adverse effects. With a single, global dose, there have prozac dosage to be casualties: with prozac dosage a potent and highly unspecific drug like fluoxetine, there will prozac dosage always be the small minority who find the average dose is more like an overdose for them. And prozac dosage response to fluoxetine is highly unpredictable too: "The broad spectrum of (its) unwanted effects is worrying, with some people becoming badly agitated and hyped up, and others brought right down; in extreme cases, manic psychoses and suicide have been mentioned as real risks" (Medawar, 1994). At the back of my mind was the thought prozac dosage that, if Prozac can make a small minority feel absolutely marvellous (Kramer, 1993), prozac dosage might it not also make another small minority feel completely wretched instead? Now, the question of dose arises again: [a] because, Eli Lilly has just introduced a 10mg tablet version of Prozac - scored, to be easily divisible into two 5mg halves; and [b] because the company prozac dosage decided that this low-dose Prozac tablet "will not be available outside the USA". The rest of the world will have to go on using the capsule formulation, i.e. an indivisible 20mg dose: "Because the new tablet version of Prozac can be split in half, it will provide greater dosing convenience for physicians. Therapy for most depressed patients using Prozac includes one 20mg capsule daily. Some patients - prozac dosage particularly older patients - occasionally are prescribed dosages of less than 20 milligrams. The new prozac dosage tablet will provide physicians with the ability to customise dosages to the needs of their patients." (Company press release, 18 May 1999) But what does this really mean? Why would Lilly now be responding to this tiny, "occasional" demand? And if there is real need, why has it taken the company and regulators a decade to respond? If this were simply to do with prozac dosage Prozac soon coming out of patent, and Lilly wanting to raise the stakes for the generic competition, why confine the change only to the USA? prozac dosage I imagine the main reason is to do with product liability, but perhaps FDA requirements come into it too. But beware of that word, "occasionally": clearly not many doctors are going to be prescribing half-strength fluoxetine if armed only with a 20mg capsule, the prozac dosage 'usual dose'. I suspect all this has something prozac dosage to do with one particularly nasty adverse effect of fluoxetine (and probably other SSRIs) - namely, "akathisia". More usually associated with anti-psychotic drugs, this is a disorder characterised by "extreme restlessness and agitation". Akathisia is increasingly mentioned in discussion about a possible link between Prozac, suicide and prozac dosage violence (Teicher et al., 1993; Healy, 1998a, 1998b, 1999). The gist of Dr David Healy's paper "A failure to warn" prozac dosage (1999) has just been prominently reported in The Guardian, but the evidence has not yet been published - though it has now been circulated in draft to the MCA/CSM among several other authorities and experts. prozac dosage It suggests real cause for concern - enough to prozac dosage prompt Healy to write to all prozac dosage coroners in England prozac dosage and Wales, as well. Usually soon after starting prozac dosage fluoxetine, a small but uncertain prozac dosage percentage of patients develop symptoms of akathisia - the severity of symptoms depending, not least, on dosage and individual prozac dosage disposition. Some other risk factors are suspected, but prozac dosage very little is known about the prevalence of the condition (Campomori et al, 1999). This is partly for lack of research but surely also because of confusion over definition and meaning. Healy's paper (1999) makes the point that "akathisia is in principle not codable" using current adverse drug reaction reporting systems: "As a result, the most authoritative compendium on psychotropics (Ayd, 1996b) can state that 'fluoxetine's propensity to cause akathisia is widely recognised' yet Lilly's published database of 42 side effects prozac dosage of Prozac does not mention akathisia" (Plewes et al., 1997). The thing is that many different terms may credibly (or not) describe what happens to patients, without using the word "akathisia" at all. The situation is also complicated because the more traditional and obvious signs of akathisia (the characteristic inability to sit down) may mask the more subtle (psychic) ones - and sometimes vice versa. The potential for deep confusion comes across vividly in an interview between Healy (1996) and one of the pioneers of psychotropic drug evaluation, Dr. Jonathon Cole: Healy: "What about a group of patients who may get worse on it (fluoxetine)? Cole: Yes. I'm one of the authors of the suicide paper … I didn't realize it would be quite that famous. I don't prozac dosage know whether Teicher (1993) or I would have published it, if we'd known, although I guess we would have done. Yes, I have seen people, at least a handful, that clearly got more agitated and got weird thoughts and suicidal drive. Tony Rothschild, who has taken over my depression programme in McLean, found three people who had jumped off something while on fluoxetine, who didn't kill prozac dosage themselves, and agreed to take it again. He re-created the same desperate driven quality with fluoxetine. Healy: Is it a form of akathisia? Cole: I think it probably is but whether you get the neuromuscular form or whether it's prozac dosage purely psychic I don't know. One patient I followed through it was so distressed by thoughts telling her to kill herself over and over again, that I never got around to asking her whether her muscles felt funny. The psychic end is so predominant that you forget to ask about the muscle end. I told her to prozac dosage take some Ativan and go to sleep and she did and within 36 hours it had prozac dosage passed. At the end of it she said 'gee, I've been depressed for 21 years, and suicidal a lot but that was ridiculous'. She thought it was clearly different than anything she had ever experienced before which is why I put her case and my name prozac dosage on the paper. Lilly doesn't believe it." The urgency and complexity of the task now prozac dosage facing the MCA/CSM and the medical establishment is further underlined by the following report, not cited in the Healy (1999) paper. It dates from not long after the days when Lilly was still wondering whether they had a drug at all: "In fact, in prozac dosage the 1970s, Eli Lilly had a conference about a drug prozac dosage they had called fluoxetine which prozac dosage they didn't know what to do with. So they had a conference at their base prozac dosage in Surrey and they asked me to make a contribution. Of course I was enthusiastic about 5HT (serotonin) and the possibilities in mood prozac dosage disorders. I always remember the Vice-President of Research saying, 'I thank Dr Coppen for his contribution, but I can tell you we won't be prozac dosage developing fluoxetine as an antidepressant'." (Coppen, in Healy, 1996). The study in prozac dosage question (Shopsin et al., 1981) gives some glimpse of what might happen to people who were unusually sensitive to fluoxetine, if prescribed something like two to three times the appropriate dose. The study was uncontrolled and involved only twelve outpatients with prozac dosage depression, with most taking fluoxetine 60mg/day - scientifically very prozac dosage thin, but still prozac dosage enough to prozac dosage show that the presumptive starting dose should be hugely reduced: "Since pharmacokinetic studies in man show that blood levels after initial doses of 60 mg/day continue to rise with decreasing dosage thereafter (apparently the drug accumulates in tissue and is reluctant to exit) we designed our study to conform with that dosage regimen. However, this leads prozac dosage to anxiety, agitation, and restlessness, which can become intolerable. We have found that prozac dosage this behavioural toxicity can apparently prozac dosage be avoided by using lower starting doses of 20mg/day with dosage progressively increased during the first week." Of the 12 patients in this study, four showed definite improvement. Note that they experienced much more prozac dosage than alleviation of depression; They evidently became quite high: "In prozac dosage the 4 patients who showed a clinical response, a stimulant-energizing like effect was documented. Although, not readily recognizable to the patient, it was clinically apparent and confirmed by the family. Assertive behavior, loquaciousness, increased energy, and general stimulant-like symptoms, rather than euphoria, were characteristic. In the 4 patients who improved, a prozac dosage sudden onset of action occurred between days 10 and 17; the onset was not insidious. Dosage was 40 mg/day in 2 patients and 60 mg/day in the other 2 patients." At the same time, four other patients deteriorated. The prozac dosage term "akathisia" is not used, but this description is prozac dosage as vivid as they come: "The 4 patients who showed symptom worsening all had increased prozac dosage anxiety, agitation, severe motor restlessness, racing thoughts, pressured speech, and assertiveness. There was a dreadful feeling of apprehension. The symptoms became unbearable in the 3 patients at different stages in treatment, 2 of whom (both females in their 50s) required hospitalization." What comes across in this brief description is that the connection between fluoxetine and prozac dosage the kind of mental distress that could provoke suicidal or violent thoughts or behaviour may be nothing like as tenuous as Lilly has prozac dosage insisted so far (Beasley et al., 1991, Nakielny, 1994, Beasley, 1998). Different patients clearly react very differently to identical doses of fluoxetine, and individuals who are unusually sensitive may sometimes respond in quite frightening ways. Akathisia seems more and more likely to be a serious problem, needing urgently to be addressed. It must be time to start writing prozac dosage to the MCA/CSM again. ======================================================== Note Twenty prozac dosage years ago, Eli Lilly prozac dosage (Dista Products) had a drug on the market called benoxaprofen. It was marketed as Opren (UK) and Oraflex (USA) and by other brand names elsewhere. Benoxaprofen (BNX) prozac dosage was an NSAID - a non-steroidal anti-inflammatory drug, used to treat the symptoms of arthritis. It was hugely over-hyped: experts were trundled out to hint that this was the greatest discovery since aspirin, perhaps capable prozac dosage of prozac dosage "arresting the disease process" in rheumatoid arthritis. The hype proved to be one of several factors in its downfall. Another factor was the dose. Extraordinary as it now might seem, BNX was licensed with a recommended dose that was identical to the recommended maximum dose - i.e. there was no "therapeutic margin". This led to problems, in particular, for some very elderly patients: the drug tended to accumulate in the body and to cause sometimes fatal liver toxicity. If BNX had been properly tested in elderly populations (those most likely to prozac dosage use it), the problem could have been anticipated and perhaps the drug would be on the market today. As it was, the recommendation to reduce the dosage prozac dosage in elderly patients came too late, and benoxaprofen was withdrawn prozac dosage worldwide in 1983. Charles Medawar, November prozac dosage 1999 Contents page What's New? |