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Copyright © 2005 by The Trustees of Columbia University Mac users: please note that our site is optimized for the Safari browser. Medications Will a break from Prozac keep me awake when I prozac and alcohol drink? Originally Published: November 14, 2003 Dear Alice, I am currently prozac and alcohol on prozac and alcohol Prozac and at college. I'm just wondering, what would happen if I stopped taking Prozac for one or two days before the weekend so that I could drink alcohol without feeling extremely prozac and alcohol sleepy? When I start taking the Prozac the next morning after drinking, will it be like starting the Prozac from square one? How prozac and alcohol long does Prozac stay in the body for? thanks! perplexed about prozac Dear perplexed about prozac, Prozac, generically known as fluoxetine, is a drug prescribed for depression and obsessive compulsive and panic disorders. Fluoxetine takes a few days to leave your system after you stop prozac and alcohol taking it. Even if you lay off before the weekend, you probably won't escape whatever side effects or interactions the drug prozac and alcohol causes in you, with or without alcohol. Similarly, if you start taking fluoxetine again after a prozac and alcohol few days off, you won't be starting again from square one. While skipping a day or two of fluoxetine may not be particularly harmful, it's a bad idea to stop taking the medication cold-turkey — fluoxetine and other anti-depressants, such as venlafaxine HCl, need to tapered off gradually in order to give the body time to prozac and alcohol adjust to the change. Fluoxetine is part of a family of drugs called selective serotonin reuptake inhibitors (SSRIs). SSRIs are used to treat depression because they affect how the brain absorbs serotonin, a chemical that transmits impulses between nerves and affects mood. Information conflicts prozac and alcohol on the effects of drinking alcohol while taking fluoxetine. Some studies suggest that SSRIs don't make the effects of alcohol stronger; nonetheless, prozac and alcohol SSRI manufacturers advise against drinking while taking an SSRI. They say that the combination can prozac and alcohol make a person drowsy (similar to what you describe),decreasing coordination and impairing judgment — more so than would be caused by drinking alcohol alone. Many health care providers also recommend against drinking alcohol while taking SSRIs because alcohol, a depressant, may interfere with the prozac and alcohol medicine's therapeutic benefits. Again, anti-depressant drugs other than fluoxetine may interact differently with booze. A family of anti-depressants drugs called tricyclics (drugs such as amitriptyline prozac and alcohol and nortriptyline), for example, can cause serious problems if taken with alcohol. You might consider your drinking patterns. For example, if your medication works for you, then why mess with it or change your medication routine to drink? What does drinking alcohol offer you? How would you feel about not drinking? How prozac and alcohol much prozac and alcohol do you usually drink at a time, over what period on a weekend? How much alcohol do you drink when you get so sleepy? Rather than altering your medication, a different plan could help you be a more-awake weekend partier. You could cut back prozac and alcohol on the amount of alcohol you drink, imbibe more slowly, sip rather than gulp, drink water between sips, and be sure to eat, to help absorb the alcohol. Finally, since drugs affect people differently, it's smart to pay prozac and alcohol attention to how you react to any drug. Since you're concerned about your drowsiness or any other ways alcohol affects you while you're taking this anti-depressant, a conversation with your health care provider is a good idea. It can give the provider information s/he may prozac and alcohol need to make necessary changes in your medication, dosage, or treatment plan. Alice Related Q&As Wellbutrin (buproprion) gets me wired! Respond to prozac and alcohol this Q & prozac and alcohol A Send this page to a friend Go Ask prozac and alcohol Alice! is not an emergency or instant response service. If you are in an urgent situation, please click here to view a prozac and alcohol list of 24 hour support services and hotlines. MIT Medical: news/health@mit 9.3 Fall 2003/Ask Lucy Periodically orange Dear Lucy: I'm 37 years old. prozac and alcohol About two days into my period, the flow turns orange. Is that normal? If not, what could be the cause?—Aunt Flo Dear Flo: For help prozac and alcohol with your question, prozac and alcohol Lucy turned to OB/Gyn nurse practitioner Dolores Vidal, R.N. According to Vidal, everyone's menstrual flow is slightly different in color, but most women describe it as red, pink, dark brown, bright red, or dark red—not orange. "Orange might be a color one could associate with a vaginal infection," Vidal notes, "but if this was the case here, I would expect an orange discharge to be noticed between periods, as opposed prozac and alcohol to the second day of the menstrual flow." And since you report no other symptoms, such as pain, irritation, or itching, Vidal thinks you are probably describing a menstrual flow that is normal for you. But, she adds, one way to settle the issue would be prozac and alcohol for you to be examined by your primary care provider or one of the OB/Gyn clinicians on a day you are having the orange flow you describe.—Lucy On the Blink Dear Lucy: What causes eye tics? I have heard that it could be the result of a magnesium deficiency or too much calcium.—Ticked Off Dear Tick: According to MIT Eye Service Chief, Robert Gross, O.D., a simple eyelid twitch does not normally indicate any underlying disease or nutritional imbalance and may occur in healthy people of any age. The condition involves fine prozac and alcohol twitching of the upper and/or lower eyelid(s) of one eye—more specifically, the orbicularis muscle, which is responsible for closing the eye. Episodes are generally brief, lasting seconds to minutes, and come and go for several days or longer. Though usually benign, an eyelid twitch may be sending an important message nonetheless—and not only to that woman across the prozac and alcohol room who thinks you just winked at her. Gross notes that this condition is often associated with fatigue, anxiety, nicotine use, or excessive caffeine intake. So, if you often experience eyelid twitching, you might try cutting back on your consumption of coffee, tea, or caffeinated soft drinks. You should also take sufficient "eye-rest breaks" from the intensity of close work. For example, while working on the computer, pause every 15 minutes prozac and alcohol to spend 20 seconds prozac and alcohol looking around the room. Learning relaxation techniques to cope with stress may also be helpful. Hope these suggestions help to keep the twitching at bay, but if it continues to be a problem despite such measures, you should have an eye exam.—Lucy Wanna java Dear Lucy: I love coffee. I drink maybe one prozac and alcohol to two cups per day. I also work out regularly at the gym, take a whey protein supplement, and eat about 30 to 40 grams of protein (fish, red meat, chicken, or the like) at each meal. Recently I heard that prozac and alcohol caffeine inhibits protein absorption into the muscles. Is there any truth to this?—Cuppa Joe Dear Joe: MIT Medical nutritionist Anna Jasonides, R.D., tells Lucy that she doesn't know of any research showing that caffeine inhibits protein absorption. "And even if it did," she prozac and alcohol adds, "I doubt one to two cups of coffee a day would make prozac and alcohol a significant difference—especially as this person's protein intake seems more than adequate." Jasonides also asked Lucy to remind you that prozac and alcohol muscle growth depends not only on adequate protein, but also on sufficient calories from carbohydrate and fat. "Whey protein is high quality, but this individual needs to be careful prozac and alcohol that the sheer amount of protein in his diet does not displace other nutrients," she cautions. Jasonides notes that healthy carbohydrate sources include whole grains, legumes, fruits, and vegetables and that healthy fats can prozac and alcohol be found in olive oil and nuts. Good luck with the bodybuilding, and enjoy that next latte!—Lucy Prozac and alcohol Dear Lucy: I am on 80 mg./day Prozac. I drink moderately most of the time, but every now and prozac and alcohol then, I "celebrate" a little too much. Does Prozac slow the metabolism of alcohol in the liver, thus keeping one's blood alcohol level higher prozac and alcohol longer?—Party Hearty Dear PH: To answer your question, Lucy turned to Ratna Bhojani, R.Ph., MIT Medical's chief pharmacist, and MIT Medical psychiatrist Adam Silk, M.D., who has been active in campus alcohol education activities. Bhojani and Silk agree that prozac and alcohol Prozac does not affect alcohol metabolism. However, Bojani cites one study indicating that alcohol use might enhance some potential adverse side effects of Prozac, prozac and alcohol including prozac and alcohol headache, nervousness, insomnia, or anxiety. But, says Silk, even though most people will experience no clinically significant effects of combining Prozac and alcohol, it may not be a good idea. "Patients who are prescribed antidepressants are usually warned not to consume alcohol while taking the medication," he explains. "Research tells us that alcohol prozac and alcohol abuse can cause depression or exacerbate an existing depression." prozac and alcohol Silk knows of no prozac and alcohol data on moderate alcohol use—not abuse—while taking an antidepressant. He defines "moderate alcohol use" as no prozac and alcohol more than two drinks at a time, no more often prozac and alcohol than twice a week, for a person with no history of substance abuse problems. Many people with a history of substance abuse problems cannot drink at all without sliding into a major relapse, Silk says. And, prozac and alcohol he adds, anyone who has been diagnosed with depression should carefully monitor his moods with a mental health clinician to determine whether even a moderate prozac and alcohol level prozac and alcohol of drinking could be adversely affecting the mood disorder. Lucy agrees with this advice. Your pattern of alcohol use may or may not be a problem for you, but given a history of depression, it's certainly prozac and alcohol worth discussing with a mental health professional.—Lucy Out of step Dear Lucy: For prozac and alcohol the last four weeks I have been experiencing a sharp, prozac and alcohol knife-cutting pain in prozac and alcohol my left arch. It occurs about two times a day. I am 55 years old and have been doing low-impact step aerobics three times a week for the last 13 years. I changed from Nike to New Balance tennis shoes three months prozac and alcohol ago. Also, two months ago, prozac and alcohol I started doing a low/high-impact aerobic class once a week. The pain is paralyzing and lasts for about ten seconds each time. What should I prozac and alcohol do?—Body and Sole Dear Stepper: First of all, Lucy commends your perseverance and diligence. It's not easy to keep up with a consistent exercise program for 13 years, and you must find this foot pain prozac and alcohol discouraging. For an answer to your question, Lucy turned to podiatrist Harry Papazian, D.P.M., of Massachusetts General Hospital, who sees MIT Medical patients prozac and alcohol by referral. Papazian immediately prozac and alcohol zeroed in on your comment about the tennis shoes and suggests that you begin trying to address your foot-pain problem prozac and alcohol with the purchase of a well-fitting shoe specifically designed for aerobics. Tennis shoes and aerobic footwear prozac and alcohol both protect the foot during quick side-to-side movements, prozac and alcohol but shoes designed for aerobic conditioning also have extra shock absorption prozac and alcohol in the sole. This is important, because impact forces from aerobics—especially the high-impact aerobics you've recently started—can reach up to six times prozac and alcohol the force of gravity. Papazian also notes that you prozac and alcohol should probably avoid aerobics for a few weeks to give your feet a chance to recover. If your pain does not resolve with the new shoes and a period of rest, you should seek professional attention. Good luck, and keep exercising!—Lucy Prozac Information - What does it do to you? 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Debt Consolidation - Settle debts and find real debt relief. Your Text Ad Here... Prozac Overview / Prozac Side Effects What Is Prozac? Fluoxetine ( Prozac ) prozac and alcohol a serotonin-specific drug is used then the patient does not respond to heterocyclic antidepressants. Fluoxetine is in a class of drugs called selective serotonin reuptake inhibitors. Fluoxetine affects chemicals in the brain prozac and alcohol that may become unbalanced and cause depression prozac and alcohol or mood disturbances, eating disorders, or obsessive prozac and alcohol or compulsive symptoms. Prozac is an SSRI. Specific Uses for Prozac: This drug is used mainly in the treatment of depression. It is also used to treat other psychological disorders, these include: prozac and alcohol OCD ( obsessive-compulsive disorder), panic disorder, and antiphobic effects. This drug may also be used in the treatment of bulimia. Fluoxetine is also used to treat premenstrual dysphoric disorder (PMDD), symptoms of which occur in the week or two before a woman's prozac and alcohol menstrual period and commonly include irritability, mood swings, and tension as well as the physical symptoms of bloating and breast tenderness. Prozac Side Effects: Anxiety or nervousness. Abnormal sweating, change in appetite, constipation, diarrhea, headache, nausea, sedation, seizure, skin rash, stomach cramps, or trouble sleeping. (If you experience any of the above serious side effects, stop taking Prozac and seek emergency medical attention or contact your doctor immediately) Click here to read what SSRI user are saying about their side effects. Prescription Drug Warnings for Prozac: Prozac is habit forming. You can become physically and psychologically dependent on the medication. Do not take more than the prescribed amount of prozac and alcohol medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if Prozac is stopped suddenly after several weeks of continuous use. DO NOT use Prozac for more than 12 months without speaking to your doctor. Do not take fluoxetine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last 2 weeks. prozac and alcohol Serious, and sometimes fatal, reactions have occurred when these medicines prozac and alcohol have been used together. Also, do not take fluoxetine if you are taking thioridazine (Mellaril). Dangerous, even fatal irregular heartbeats may occur if these medicines are taken together. You must wait 5 weeks after stopping fluoxetine before taking thioridazine (Mellaril). Avoid alcohol while taking Prozac. Alcohol may increase drowsiness and dizziness caused prozac and alcohol by Prozac. You should tell your prozac and alcohol doctor if you are pregnant, plan to become pregnant, or are breast-feeding while you are taking Prozac. prozac and alcohol Use caution prozac and alcohol when driving, operating machinery, or performing other hazardous activities. Fluoxetine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these prozac and alcohol activities. Prozac may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you prozac and alcohol are taking, and do not take any medicine without first talking to your doctor. Alternatives to SSRI's like Prozac: If you prozac and alcohol are considering taking an SSRI like Prozac, I would ask that you give an alternate solution a try. SSRI's did nothing for me but make me dependant on them and prozac and alcohol when I tried to stop taking them, I sank into very deep states of depression for weeks at a prozac and alcohol time. When you stop taking the SSRI, it will prozac and alcohol really mess up the chemical balance in your brain. Remember, prozac and alcohol by taking an SSRI, your brain is synthetically forced to create the chemicals in the brain that help to rebalance your condition. When these chemicals are no longer being forced into your body by the SSRI, the results can be hazardous and dangerous. If you start taking an prozac and alcohol SSRI, plan on taking it for a very long time as it is very hard to quit prozac and alcohol and stay sane. In addition, you will literally spend thousands of dollars prozac and alcohol on prescription costs over the years you have to take the drug. There are a few excellent alternative solutions out there. Alternative herbal medicines like St. Johns Wort, Kava Kava, prozac and alcohol Valerian Root, 5-HTP and SAM-e have all been used in clinical studies with excellent results in patients with anxiety and depression related symptoms. Combination therapy products like Clarocet NRI can help provide natural chemical mood enhancement without the dangerous side effects of prescription drugs. Remember that any sort of chemical balancer, be it a prescription drug like Prozac or a natural alternaitve, only targets the symptoms prozac and alcohol of anxiety and prozac and alcohol depression. Though they can provide short term and long term relief, the only permanent solution is identifying your feelings and developing coping techniques that can help. Cognitive behavior therapy or consulting with a therapist can help you prozac and alcohol do this. Featured Prescription Medication Resource Partners Mental Health Center - Learn about modern medications and what they do. 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By Jake Van Der Borne (08/07/03) Side Effects and More - An article that overviews the side effects of popular prescription drugs. By Jake Van Der Borne (09/03/04) The Real prozac and alcohol Cost of Your Prescription Drugs - Are the prescription drug companies ripping you off? You will be surprised at the actual cost of your prescription drugs. prozac and alcohol By Sharon prozac and alcohol Davis and prozac and alcohol Mary prozac and alcohol Palmer prozac and alcohol (07/03/04) Selective Serotonin Reuptake Inhibitors (SSRI) - SSRI's: What they are and how they are believed to work. prozac and alcohol Read about warnings and side effects. By Jake Van Der Borne prozac and alcohol (08/12/03) MAOI: Monoamine Oxidase Inhibitor - What is an MAOI? How does it work? What can it do prozac and alcohol to you?. By Jake Van Der Borne (09/04/04) Anxiety Attack Management - Causes of anxiety, treatment options for anxiety, information resources for Xanax and more. By Dr. Johnson. (03/15/05) An Overview prozac and alcohol of Serotonin Syndrome - What is serotonin syndrome and what can I do to avoid it? By Jake Van Der Borne (04/21/04) Death of Our Daughter Due to Zoloft - A true story of zoloft and its effects. By Alan Kennedy (11/04/04) SUBMIT AN ARTICLE OR PERSONAL EXPERIENCE Prozac Top If you experience anxiety, depression or related symptoms, it is recommended that you consult a professional about your treatments options. Anxiety, Depression, social anxiety prozac and alcohol and related disorders are serious conditions that require the assistance of a doctor, psychologist, psychiatrist or other qualified practitioner. Consult a physician about taking Prozac with any non-prescription alternative. If you prozac and alcohol are planning on discontinuing Prozac you must speak with a doctor about slowly stopping this drug. The anxiety and depression information on this website is intended solely for informational purposes. Anxiety and Depression Solutions reserves all right to content and material on this website. Copyright - Anxiety and Depression Solutions - 2002- 2004. ICFDA Alcohol Cravings Induced via Serotonin Alcohol Cravings Induced via Increased Serotonin by Ann Blake Tracy, Director, ICFDA There is an alarming connection between alcoholism and the various prescription drugs prozac and alcohol that increase serotonin. The prozac and alcohol most popular of those drugs are: PROZAC, ZOLOFT, PAXIL, prozac and alcohol LUVOX, SERZONE, EFFEXOR, ANAFRANIL, and prozac and alcohol the new diet pills, FEN-PHEN and REDUX. For seven years numerous prozac and alcohol reports have been made by reformed alcoholics (some for 15 years and longer) who are being "driven" to alcohol again after being prescribed one of these drugs. And many other patients who had no previous history of alcoholism have continued to prozac and alcohol report an "overwhelming compulsion" to drink while using these drugs. (A few personal accounts: #1 A young woman, a recovering alcoholic, reported that during the eight month period she had been using Prozac she found prozac and alcohol it necessary to attend AA meetings every day in order to fight off the prozac and alcohol strong compulsions to begin drinking again. prozac and alcohol #2 In the Southeastern United States a middle aged psychologist, also a recovering alcoholic, after being prozac and alcohol prescribed Prozac, found herself needing to attend AA meetings morning, noon, and night to keep from destroying the sobriety she had achieved. #3 A young prozac and alcohol father, who was Mormon and had never before in his life used alcohol, found himself drinking Ever prozac and alcohol Clear and exhibiting bizarre as well as violent behavior, after being prescribed Prozac and prozac and alcohol Ritalin. #4 A young mother prozac and alcohol who had never used alcohol before began drinking large amounts within weeks of being prescribed Prozac and quickly found herself committed to a mental institution due to the psychotic behavior that resulted. Added to her prozac and alcohol Prozac prozac and alcohol prescription were anti-psychotic meds and electric shock treatments. She then began to experience seizures and was started on anti-seizure meds. #5 A concerned neighbor reported prozac and alcohol her friend was drinking straight Vodka on a regular basis after being prescribed Zoloft. #6 A daughter reported prozac and alcohol her father, sober for 15 years, began drinking again on Prozac. The consistant report from these patients has been an "overwhelming craving or compulsion" for alcohol.) For some time we did not have specific medical documentation to help us understand prozac and alcohol why this was happening. Could it be that Prozac, Zoloft, Paxil, etc., being mood altering substances, were removing the inhibitions that individuals had placed upon themselves to stop their additions? But beyond this mood altering effect of Prozac, etc., there seemed to be a physiological cause for this alcoholic obsession as well. There were reports of prozac and alcohol people who rarely drank before Prozac, etc., consuming excessive amounts of alcohol after starting usage of these various drugs. For example prozac and alcohol we have the case of a young newly wed in Southern Utah who was given Prozac for a hormonal imbalance. Before that time she would have prozac and alcohol two or three social drinks a year, yet soon after being prescribed Prozac she began bringing alcohol home by the case. Many similar reports followed. Could prozac and alcohol it be that because these drugs have such a strong prozac and alcohol adverse effect upon the pancreas [Manufacturer's warnings include such side effects as hypoglycemia, diabetes and pancreatitis.] they are producing a potent disruption in the body's blood sugar balance? This would in turn cause a "craving" for alcohol as the body reaches out for a prozac and alcohol "quick fix" to raise prozac and alcohol the blood sugar prozac and alcohol level thus triggering a vicious self-perpetuating cycle as the alcohol pushes the blood sugar level even lower after the brief high it produces. This means that those suffering a tendency toward alcoholism or any other blood sugar disorder prozac and alcohol would suffer the prozac and alcohol most disastrous repercussions of Prozac, etc., prozac and alcohol (including psychosis, suicidal ideation and violence) much faster than most. Patient reports support this conclusion. In November of 1994 Yale published prozac and alcohol a study that gave us one answer to the alcohol cravings associated with these prozac and alcohol drugs. The study demonstrated that an increase in brain levels of either of two neurotransmitters (brain hormones), serotonin or noradrenalin, prozac and alcohol produces: #1 a craving for alcohol, #2 anger, #3 anxiety. They found this to be especially true for those who have prozac and alcohol a history prozac and alcohol of alcoholism. All of prozac and alcohol the drugs listed above are designed in one way or another prozac and alcohol to increase prozac and alcohol serotonin which in turn also increases noradrenalin. Anyone who has a history of alcoholism should heed the warning contained in these prozac and alcohol reports. And anyone who has developed a problem with alcoholism while using these drugs deserves answers as to why they have experienced such an prozac and alcohol overwhelming compulsion to drink. America already has an estimated 10 -15 million alcoholics. To increase that number with a reaction from prescription drugs which causes a compulsion to drink is prozac and alcohol a tragedy! What a sad state of affairs prozac and alcohol that drugs which are actually being promoted as a treatment for alcoholism have the potential to create alcohol craving behavior. This is not only frightening, but absurd. It is heart-rending to listen to those who have had years of sobriety destroyed almost overnight or those who have never touched alcohol before Prozac, yet began drinking compulsively due to prozac and alcohol a medication prescribed by doctors unfamiliar with this connection. By chemically inducing an overwhelming urge to drink this effect also causes patients to mix alcohol with these powerful drugs. When alcohol and drugs are combined, one can compound the effects of the other so the resulting impairment is far worse than if the two were taken separately...even small amounts, mixed with some medicines, will deaden your senses or change your perceptions which can lead to psychotic behavior, seizures, etc. Those in this situation need to be made aware that they are not alone, and that this is a common report which is now substantiated by prozac and alcohol medical documentation. They also need to understand that it is possible to very gradually withdraw from these drugs and overcome these adverse drug reactions. For an in depth exploration of this subject see the book PROZAC: PANACEA OR PANDORA? by Ann Blake prozac and alcohol Tracy. For order information call 1-800-280-0730 or visit the website. Other references for this material: Krystal JH, Webb; E, Cooney N.; et al., "Specificity of Ethanol-like Effects Elicited in Serotonergic and Noradrenergic Mechanisms," ARCHIVES OF GENERAL PSYCHIATRY, Vol. 51, Issue 11, pgs 898-911. (This is the Yale study mentioned above.); In a study conducted by Liisa Ahtee and Kalervo Eriksson (Physiology and Behavior, Vol. prozac and alcohol 8, pp. 123-126, 1972) rats which preferred alcohol had 15-20% higher concentrations of serotonin in the brain. ICFDA prozac and alcohol Study This is Study number 17. Total number of studies in current database is 27 11/12/2001 Prozac triggers increase in aggression in mice http://www.newscientist.com/news/news.jsp?id=ns99991553 Emma YoungSan Diego New Scientist The anti-depressant Prozac causes prozac and alcohol a dramatic increase in aggressive behavior in mice the day after the drug is administered, US researchers have found. Prozac, or fluoxetine, has been associated prozac and alcohol with isolated reports of suicide and crimes of violence in people. "But this has been difficult to study in other animals," says George Wagner of Rutgers prozac and alcohol University. "Our findings represent the first demonstration that the drug can actually increase prozac and alcohol defensive aggression in other species.” When the mice received alcohol along with Prozac, their aggression scores on prozac and alcohol the following day were even higher. "Our data indicate a potentially serious interaction between Prozac and alcohol," Wagner adds. However, the implications prozac and alcohol for the millions of people who take Prozac worldwide are unclear, Wagner says. The mice in his study were given a single, very high dose of the drug. The effects of regular, much smaller doses over a long period of time might be prozac and alcohol different, he says. John Mann of Columbia University, US, says: "This is a very interesting observation. But individual case reports of people exhibiting suicidal or aggressive behavior have been found with practically every psychotropic prozac and alcohol medication. Every double blind study of people taking Prozac to date has not indicated an association with prozac and alcohol increased aggression. "Protruding prozac and alcohol object Mann's team investigated the effects prozac and alcohol of prozac and alcohol Prozac alone, alcohol alone, and Prozac plus alcohol on two types of aggression: offensive and defensive. "Offensive would be two males fighting over territory, for example," says Mann. "Defensive involves an aggressive response to a painful or frustrating stimuli. "Mice prozac and alcohol in the three drug groups were put in a cage together, to investigate offensive aggression, or given a mild electric shock, to investigate defensive aggression. In the second case, the mice's tendency to bite an inanimate object protruding into prozac and alcohol their cage in response to the shock was measured. Prozac prozac and alcohol is thought prozac and alcohol to work by prolonging the presence of the neurotransmitter serotonin in prozac and alcohol the brain. Low levels of serotonin are associated both with alcohol consumption and with aggression. The team expected that alcohol alone would prozac and alcohol boost aggression - and that this effect would be counteracted by an accompanying dose of Prozac. Prozac alone was expected to decrease aggressive behavior. On the day the drugs were given, that was exactly what they found. prozac and alcohol But on the second day, they found that defensive aggressive behavior in mice that had received Prozac prozac and alcohol alone prozac and alcohol rocketed by between 15 and 20 per cent, compared with baseline measurements. In mice that had prozac and alcohol also received alcohol, prozac and alcohol it increased by between 20 and 25 per cent. There was no effect on offensive aggressive prozac and alcohol behavior. Impulsive behavior Prozac causes a decrease in levels of a serotonin metabolite called 5-hydroxyindoleacetic acid (5HIAA). Low levels of 5HIAA have been associated with suicides, especially violent ones, as well as with other violent or impulsive behavior. Wagner's team recorded the lowest levels of 5HIAA on the day after the mice received the Prozac. "We found lower levels of 5HIAA in our mice long prozac and alcohol after they received fluoxetine," says Wagner. "That may help explain their increased aggression. "The team now plans to investigate the effects of chronic Prozac use on aggression in animals. Wagner presented his research at the Society for Neuroscience annual conference in San Diego.13:10 12 November 01For exclusive insights into the most important developments in science and technology this week, see New Scientist Print Edition Subscribe to New Scientist Print Edition prozac and alcohol and get free access to 10 years of the magazine in our prozac and alcohol online archive Correspondence about this story should be directed to latestnews@newscientist.com. Sign up for our free newsletterThe Society for Neuroscience |