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Company X announces Product Y, a treatment for Condition Z, a problem that's baffled the best minds in pros and cons of prozac science pros and cons of prozac for years. The media jumps on Product Y's bandwagon, accentuating positives, eliminating negatives, and generally rhapsodizing about how great it's going to be without Z around, messing up all our lives. Sales skyrocket, caution is thrown to the wind, and everyone pros and cons of prozac basically hopes for pros and cons of prozac the pros and cons of prozac best. Sound familiar? If so, the rest of the story should, too. Times passes. A report is published, linking Y to Side Effects A, B, and C. The media weighs in again, now clucking that the early euphoria was pros and cons of prozac premature, and declaring that a closer, careful look at Y is clearly in order. Public-interest groups leap into the fray. They petition the U.S. Food and Drug Administration for [take your pick] new controls/warning labels/an outright ban. They charge that X rushed Y into release without sufficient concern for possible problems. The first lawsuits are filed. Attorneys for Ms. Q or Mr. E file $100 million liability suits, alleging that X knew all along that Y was dangerous, and pressed on in a callous display of greed to bring a bad product to a gullible market. More time passes. The public pros and cons of prozac is confused. Is Y still a cure for Z pros and cons of prozac or a deadly rip-off that causes A, B, and C? If the above scenario sounds absurd, it is. But it's often more fact than fiction. And it certainly covers most of the public perceptions about Prozac® over its first decade as blues-busting antidepressant Numero Uno. Prozac drew raves early on, due to its effectiveness in undoing depression and other problems. Later, it started getting hammered by critics who charged that it causes a range of adverse effects, even suicide and other acts of violence. Sound confusing? It is. That's one reason that a closer, careful look at Prozac — and the expanding universe of antidepressant drugs like it — clearly is in order. Because pros and cons of prozac the fact is that pros and cons of prozac both views have at least a little truth in them. And that's what makes sorting things out such a challenge — and so necessary. What is Prozac? Prozac is an example of a new class of drugs used to treat depression and other emotional problems. Its chemical name is fluoxetine. Released in 1987, pros and cons of prozac Prozac turned heads from the start, pros and cons of prozac both literally and figuratively. In the process, it became the most popular antidepressant in the United States (14 million Americans have used it so far) and one of the most talked-about drugs in the world. In fact, for a time, Prozac seemed more than just a drug. It was a cultural phenomenon, the subject of an intense media fascination that played itself pros and cons of prozac out on magazine covers and TV talk shows and best-seller lists for years, and an equally intense (and prolonged) debate into the ethics of using drugs to change our feelings the way we once could only change our underwear. The interest proved so profitable for its manufacturer that it inspired a frenzy of interest in the pharmaceutical industry pros and cons of prozac to develop chemicals like it. The result has been a tide of new act-alike drugs (including Paxil®, Zoloft®, and others), known collectively as selective serotonin reuptake inhibitors — SSRI's, for short. Similar to traditional antidepressants — including tricyclic antidepressants (TCA's) and monoamine pros and cons of prozac oxidase inhibitors (MAOI's) — in some ways, SSRI's differ in the way they actually work in pros and cons of prozac the body. How do they work? By altering the action of a specific set pros and cons of prozac of neurotransmitters, chemicals involved in the transfer of signals from cell to cell in the central nervous pros and cons of prozac system. Specifically, SSRI's increase the supply of serotonin, pros and cons of prozac a neurotransmitter that figures into mood, pain, sleep, and pros and cons of prozac a variety other body/brain processes. They do that by blocking removal of serotonin from its receptors in the brain. pros and cons of prozac By stopping these receptors from "turning off" serotonin, Prozac and drugs like it permit more of the transmitter to be available at the synapse, the gap between nerve cells. For pros and cons of prozac reasons no one fully understands, this simple biochemical change often results in improved mood. How are SSRI's different from other antidepressants? Other drugs affect more body systems — and cause more potential problems in the process. TCA's, for example, interact with other neurotransmitter systems. Like Prozac, they boost serotonin, but also pros and cons of prozac affect another neurotransmitter, norepinephrine. MAOI's work differently. They block monoamine oxidase, an enzyme that breaks down other neurotransmitters in addition to serotonin. Like Prozac, pros and cons of prozac MAOI's and TCA's all reduce depression. And also like Prozac, no one pros and cons of prozac really knows why they work — only that they usually do work, probably by increasing the available supply of serotonin. Which is better? That depends on who you ask. According to the Public Citizen Health Research Group, a Washington-based consumer health advocacy group, Prozac works well but is "somewhat less effective" than a common tricyclic, imipramine. Others give Prozac and the SSRI's higher marks, claiming that the drugs can trigger transformations of self so total that some users say they "feel like pros and cons of prozac [themselves] for pros and cons of prozac the first time" in their lives — which raises profound questions about who we are and how we know for sure. Still, even the biggest boosters of SSRI's acknowledge they only work about 60-70 percent of the time — the same as other pros and cons of prozac antidepressants. But even if the pros and cons of prozac new drugs don't always pros and cons of prozac work better, they are usually safer than older antidepressants. In fact, earlier drugs caused so many side effects that many users were unable to stay on them long enough to derive any real benefit. SSRI's have side effects, too, but they're usually milder and more manageable. What sort of side effects? That depends on the drug, but common initial problems often include nervousness and pros and cons of prozac insomnia, or drowsiness and fatigue. Skin rash, nausea, and diarrhea also occur. An effect common to many SSRI's is some degree of sexual dysfunction — ranging from an inability to achieve orgasm all the way to a complete loss of interest in sex. Some researchers guess the rate pros and cons of prozac of SSRI-related sexual impairment at up pros and cons of prozac to 50 percent. The risk of other problems is low, but real. In fact, Prozac's manufacturer admits that 15 percent of all patients receiving Prozac in pre-release trials stopped taking it due to adverse reactions. Still, most therapists (and pros and cons of prozac most of their patients) think SSRI's stack up pretty well against the competition, since both TCA's and MAOI's can cause weight gain, changes in blood pros and cons of prozac pressure and heart beat, constipation, and blurred vision. And SSRI's look better pros and cons of prozac still when you add in some of their "good" side effects. What 'good' side effects? One of the SSRI's "best" side effects — or, pros and cons of prozac at least, most users' favorite — is appetite reduction and weight loss. In fact, that was a big reason that Prozac found fame so fast. In one study, 65 percent of Prozac users lost at least a pound during a six-week testing period. And two tests involving subjects who were overweight but not depressed made Prozac (and presumably pros and cons of prozac the subjects) look even better, with an average loss of 10 pounds over 8 weeks. On pros and cons of prozac the other hand, Prozac doesn't fight fat for everyone. In pros and cons of prozac fact, underweight people tend pros and cons of prozac to gain weight while on the drug. And although researchers aren't sure why, they suspect it's linked to Prozac's pros and cons of prozac effects on serotonin and its role in appetite control. Do SSRI's pros and cons of prozac help with other problems? As a matter of fact, they do. They've been tried with varying degrees pros and cons of prozac of success against a variety of other problems, including obsessive-compulsive disorder, panic, eating disorders, Tourette's syndrome, borderline personality pros and cons of prozac disorder, and schizophrenia. More research is needed, but results thus far have advanced the view that pros and cons of prozac there may well be a single biochemical basis for these and other pros and cons of prozac mental health problems — and reinforced researchers' determination to prove it. And for the present, evidence strongly suggests that the common link is serotonin. Wonder Drugs If all the "wonder drugs" that have appeared in recent years, none has excited more interest or created more controversy than Prozac and the new antidepressants that have bubbled up in its wake. That shouldn't be surprising. If a drug is effective enough to attract major notice when it's released, it's probably powerful enough to generate a backlash. That's certainly been the case here. The fact is that Prozac is a powerful drug that operates at a deep level of the brain to correct a biochemical imbalance that not only seems to underlie depression, but a variety of other body/mind problems as pros and cons of prozac well. Does it work? It seems to, for most people who take it pros and cons of prozac as directed. Still, everyone who uses it or a drug like it should be aware of potential side effects and notify their physician of problems immediately — particularly if the depression worsens or they begin to feel suicidal. The fact is that the new SSRI's have produced amazing results for many users. But that shouldn't pros and cons of prozac obscure the fact that pros and cons of prozac others have had problems pros and cons of prozac with them. That's worth keeping in mind as we consider Prozac's risks and benefits and weigh pros and cons of prozac its pros and cons. Because even though Prozac is a wonder drug in many ways, it's also a wonder pros and cons of prozac how easily we forget that it — and drugs like it — can cause problems as easily as they take them away. Sidebar: Brave New Drugs: Downside Guide Drug® generic name Dose/day Possible Side Effects Effexor®/venlafaxine 75-375 mg high blood pressure sexual dysfunction Paxil®/paroxetine 20-50 mg fatigue sexual dysfunction Prozac®/fluoxetine 20-80 mg anxiety insomnia sexual dysfunction Serzone®/nefazodone 300-600 mg drowsiness Welbutrin®/buproprion 300-450 mg weight loss slight (.4%) risk of seizures Zoloft®/sertraline 50-200 mg drowsiness insomnia sexual dysfunction Sidebr: Violence & pros and cons of prozac Prozac: Is there a Connection? Although the initial response to Prozac was mostly euphoric, rumors have swirled around it since the early years, alleging a fearful, dark side to the drug, including incidents of murder and suicide by users. At times, the rumors have even seemed a roar as ex-users came forward with charges pros and cons of prozac that Prozac caused violent or suicidal impulses — a process helped along by critics in the Church of Scientology, which has coordinated an anti-Prozac information campaign as a part of pros and cons of prozac its larger pros and cons of prozac goal of discrediting psychiatry in pros and cons of prozac general and psychiatric drugs in particular. And while the furor may have died down, for many people the question still pros and cons of prozac remains: Does Prozac ever cause violence or suicide? The question pros and cons of prozac is complex, but the best answer seems to be no, according to the U.S. Food and Drug Administration. The FDA points out that all antidepressants can cause a level of arousal that can be disorienting, at first. And pros and cons of prozac these pros and cons of prozac feelings usually do emerge before the pros and cons of prozac full antidepressant effects of the drug kick in, and could pros and cons of prozac conceivably push a depressed user past the line that separates self-preservation from self-destruction. Regardless, Prozac advocates claim, the documented risk of suicide is greater with tricyclics pros and cons of prozac — and pros and cons of prozac even with placebos — than it is pros and cons of prozac with Prozac. And the highest known suicide risk pros and cons of prozac factor of all pros and cons of prozac is pros and cons of prozac untreated depression. The best solution, according to experts, is educating patients about possible pros and cons of prozac side effects and maintaining close communication with the prescribing physician to reduce the risk of side pros and cons of prozac effects ever getting out of hand. This is one in a series of publications on drugs, behavior, and health published by Do It Now Foundation. Please call or write pros and cons of prozac for a complete list of available titles, or check us out online at www.doitnow.org. Pros and pros and cons of prozac Cons of Prozac and Its Relatives -- 157 (3): 323 -- American Journal of Psychiatry HOME HELP FEEDBACK SUBSCRIPTIONS ALL ISSUES SEARCH TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is pros and cons of prozac posted Services Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Related Collections Antidepressants Anxiolytics Am J Psychiatry 157:323-325, March 2000 © 2000 American Psychiatric Association Editorial Pros and Cons of Prozac and Its Relatives The past decade has witnessed a tremendous shift in how we treat patients who suffer from depressive or anxiety disorders. Selective serotonin reuptake inhibitors (SSRIs) have become first-line agents pros and cons of prozac for pros and cons of prozac patients with major depression, dysthymia, panic disorder, obsessive-compulsive disorder, social pros and cons of prozac phobia, etc., and their U.S. sales top $6 billion annually. The effects of these agents on our social fabric have perhaps been even greater, with pros and cons of prozac brand names of specific drugs (e.g., Prozac) commonly used in English parlance. In fact, there are many in the lay population who worry we may be becoming too "dependent" on these agents to maintain our mental health. Fluoxetine (Prozac), the original SSRI in this country, remains the leader of the pack in dollar sales. In spite of pros and cons of prozac its widespread use, there are many academics who question whether it pros and cons of prozac is as effective as the older tricyclic antidepressants pros and cons of prozac or monoamine oxidase inhibitors (MAOIs) in a number of special circumstances—e.g., pros and cons of prozac severe depression, atypical depression. Four articles pros and cons of prozac in this issue of the Journal highlight some features and limitations of the wide-scale use of SSRIs, particularly fluoxetine. The study of Robinson et al. on poststroke depression pros and cons of prozac and recovery pros and cons of prozac indicates that fluoxetine is pros and cons of prozac not effective for these patients and is consistent with the previous observations by Roose et al. (1) of depressed patients with heart disease. In the Robinson et al. study, pros and cons of prozac fluoxetine was not more effective than placebo in poststroke depression, whereas nortriptyline was highly effective. Neither drug was effective in aiding recovery in nondepressed patients. Taken together, these studies suggest that norepinephrine reuptake blockade is important in elevating depressive affect in some elderly subjects. Of interest is another recent study by Roose pros and cons of prozac et al. (2), which demonstrated that both nortriptyline and paroxetine were effective in depressed patients with ischemic heart disease, suggesting that the observation of Nemeroff’s pros and cons of prozac group (3, 4) that paroxetine may block norepinephrine reuptake in addition to acting on the serotonin transporter may be clinically valid. Thus, all SSRIs may not enjoy equal efficacy in specific populations. A direct head-to-head comparison of paroxetine and fluoxetine in depressed patients with vascular disease (cardiac or cerebrovascular) would be of considerable interest to the field. Patients with atypical depression were shown several years ago to be more responsive to MAOIs than to imipramine or placebo (5, pros and cons of prozac 6). The article by McGrath and colleagues in this issue indicates equivalent efficacy of fluoxetine and imipramine for this disorder and thus suggests that fluoxetine may be less effective than an MAOI in atypical depression. Unfortunately, since we do not have such comparison data, we cannot be certain of this conclusion, and, as the authors point out, for practical reasons (e.g., the safety of MAOIs) we are unlikely to pros and cons of prozac ever have these data. Thus, in fluoxetine for atypical depression we have an agent that has clear efficacy (McGrath et al.), is safe and easy to use, but may not be the most effective medication available. Here too a head-to-head trial of fluoxetine versus phenelzine would be highly informative for clinical practice. Even if fluoxetine turned out to be not as effective as an MAOI in atypical depression, its relative efficacy as compared to placebo and its tolerability and wide safety pros and cons of prozac margin still make it a useful agent in this disorder. Indeed, these advantages for fluoxetine and pros and cons of prozac the other SSRIs largely explain their success to date. The earlier agents—tricyclic antidepressants and MAOIs—were problematic in regard to their side effects and smaller safety margins. SSRIs have pros and cons of prozac allowed for a wider range of patients, including those with milder disorders, to be treated successfully and easily in the community. In a sense, they may be more broadly effective but may not be more effective for specific populations than older agents. Herein lie their advantages and their potential limitations. The last two pros and cons of prozac studies in this group point to the ease of use pros and cons of prozac of SSRIs. Thompson and colleagues, using a variety of methods to assess pros and cons of prozac compliance in primary care, found significantly greater consistency of use for fluoxetine than for the European tricyclic antidepressant dothiepin. The pros and cons of prozac study used a medication event monitoring system—a computerized pill container—to assess how reliably patients took their medications. Using cruder assessments of pill-taking behavior, Thompson pros and cons of prozac et al. noted no superiority of fluoxetine over pros and cons of prozac dothiepin. In contrast, superior compliance for fluoxetine was determined with the more objective medication event monitoring system. Of particular importance was that the patients who pros and cons of prozac were more compliant also demonstrated greater improvement than those pros and cons of prozac who were not. Thus, taking one’s medications helps (thank the Lord), and that is one of the things SSRIs allow for—i.e., greater surety in compliance. A result of the extensive use of pros and cons of prozac SSRIs is highlighted in pros and cons of prozac the article by Mamdani and colleagues. Using an pros and cons of prozac Ontario pros and cons of prozac database on drug utilization, pros and cons of prozac they found that since the introduction of SSRIs into Canada, the utilization and costs pros and cons of prozac of antidepressants for the elderly have increased dramatically. Exploring prescriptions of antidepressants from 1993 to 1997, they noted an increase in the prevalence of antidepressant use by the elderly from 9.3% to 11.5%, with SSRIs growing from 9.6% of antidepressant prescriptions to 45.1% over that period. The increase pros and cons of prozac in total expense was due largely to a switch from almost entirely generic tricyclic antidepressants to the SSRIs. This increase occurred despite the fact that generic pros and cons of prozac fluoxetine pros and cons of prozac became pros and cons of prozac available in Canada in 1995. While the increased use of SSRIs and the resultant higher costs may pros and cons of prozac be of concern to health care economists, such costs must be weighed against such potential benefits as 1) better efficacy and restoration of function, because the agents are often better tolerated (a point questioned by Mamdani and colleagues in their article) and patients are understandably more compliant with their treatment (see preceding discussion), and 2) the potential savings in emergency room visits and stays in the intensive pros and cons of prozac care unit pros and cons of prozac associated with overdoses. pros and cons of prozac Further large-scale studies on the cost-benefit ratio would aid in assessing the value of switching from tricyclic antidepressants to pros and cons of prozac SSRIs. (As Mamdani et pros and cons of prozac al. argue, such studies should be performed with pros and cons of prozac nortriptyline, a secondary tricyclic antidepressant with fewer side effects than a tertiary agent, such as pros and cons of prozac amitriptyline.) Still, the increased prescriptions of SSRIs suggest that there is at least a reasonable level of satisfaction pros and cons of prozac with this class of agents in the elderly, and although this study did not focus on fluoxetine, the data are in keeping with the findings from a large-scale study of geriatric depression (7), in which fluoxetine was significantly more effective than placebo. Perhaps no other class of antidepressants has affected pros and cons of prozac our practice in the same way or to the same degree as the SSRIs. Today, 12 years since their introduction, we still need further studies on the similarities and differences among members of the class in both efficacy and tolerability, as well as further data on the relative efficacy and safety of the SSRIs versus tricyclic antidepressants or MAOIs for special populations. Such studies not only will help us to understand better how we can best use these agents but also will assist in laying a template for assessing new classes of antidepressants and anxiolytics in the future. FOOTNOTES Address reprint requests to Dr. Schatzberg, Department of Psychiatry, Stanford University Medical Center, 3rd Floor, 401 Quarry Rd., Stanford, CA 94305-5717; afschatz{at}leland.stanford.edu (e-mail). REFERENCES Roose SP, Glassman AH, Attia E, pros and cons of prozac Woodring S: Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia. Am J Psychiatry 1994; 151:1735–1739 Roose SP, Laghrissi-Thode F, Kennedy JS, Nelson JC, Bigger JT Jr, Pollock BG, Gaffney A, Narayan M, pros and cons of prozac Findel MS, McCafferty J, Gergel I: Comparison of paroxetine and nortriptyline in depressed patients with ischemic heart disease. JAMA 1998; pros and cons of prozac 279:287–291[Abstract/Free Full Text] Owens MJ, Morgan WN, Plott SJ, Nemeroff CB: Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther 1997; 283:1305–1322 Owens MJ, Knight DL, Nemeroff pros and cons of prozac CB: Paroxetine binding in the rat norepinephrine transporter in vivo. Biol Psychiatry (in press) Quitkin FM, Stewart JW, McGrath PJ, Liebowitz MR, Harrison WM, Tricamo E, Klein DF, Rabkin JG, Markowitz JS, Wager SG: Phenelzine versus imipramine in pros and cons of prozac the treatment of probable atypical depression: defining syndrome boundaries of selective MAOI responders. Am J Psychiatry 1988; 145:306–311[Abstract] Quitkin FM, McGrath PJ, Stewart JW, Harrison W, Tricamo pros and cons of prozac E, Wager SG, Ocepek-Welikson K, Nunes E, pros and cons of prozac Rabkin JG, Klein DF: Atypical depression, panic attacks, and response to imipramine and phenelzine: a replication. Arch Gen Psychiatry 1990; 47:935–941[Abstract] Flint AJ: Pharmacologic treatment of depression in late life. Can Med Assoc J 1997; 157:1061–1067 This Article Full Text (PDF) Alert me when this article is cited Alert me if pros and cons of prozac a correction is posted Services Email this pros and cons of prozac article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Related Collections Antidepressants Anxiolytics HOME HELP FEEDBACK SUBSCRIPTIONS ALL ISSUES SEARCH TABLE OF CONTENTS Prozac (fluoxetine) - The Crazy Meds run-down US Brand Name: Prozac A link here will take you to the official website for the drug. See below for additional brand names Generic Name: fluoxetine hydrochloride Other Forms: Prozac Weekly, Sarafem (for PMDD), oral solution Class: Antidepressant, specifically SSRI. Read up on these sections if pros and cons of prozac you haven't done so already, because pros and cons of prozac they cover a lot of information pros and cons of prozac about multiple medications that I'm not going to repeat on many pages. I'm just autistic that way about not repeating myself. FDA Approved Uses: Major Depression, Obsessive-Compulsive Disorder, Panic Disorder, Bulima Nervosa, Premenstrual pros and cons of prozac Dysphoric Disorder (as Sarafem). Prozac (fluoxetine hydrochloride) is the only SSRI (and modern antidepressant in pros and cons of prozac general) approved for use by the under-18 set for depression, probably due to its long half-life pros and cons of prozac and lower potency. Off-Label pros and cons of prozac Uses: Fibromyalgia, Arthritis, Chronic Fatigue, Multiple Sclerosis, Bipolar Depression, Lupus, Headaches, Irritable Bowel Syndrome (IBS), ADD/ADHD, Premature Ejaculation, Autistic Spectrum Disorders Prozac's pros and cons:Pros: pros and cons of prozac Prozac's long half-life makes the issue of med compliance a little less of a big deal, hence the approval pros and cons of prozac for depressed teenagers. It also has studies backing it up for PMDD, by Lilly and independent researchers, including the Amen clinic, where I'm treated. You pros and cons of prozac can see at the Amen Clinic's case studies in practice the more common form pros and cons of prozac of PMDD that responds to SSRIs will respond to whichever SSRI you get along with the best. Prozac Weekly does have an advantage for certain forms of PMDD. Cons: That really long half-life means it takes forever to wean yourself off of Prozac (fluoxetine hydrochloride) to avoid SSRI discontinuation syndrome. But only if the discontinuation syndrome hits you hard, which is fairly uncommon with Prozac (fluoxetine hydrochloride). In fact some more enlightened doctors will pros and cons of prozac prescribe the liquid form to help wean patients off pros and cons of prozac of other SSRIs and Effexor (venlafaxine). The sexual side effects, though, are pretty bad. For being the weakest of the SSRIs the side effects are pretty gnarly. Prozac's side effects: Typical Side Effects: The usual pros and cons of prozac for SSRIs - headache, nausea, dry mouth, sweating, sleepiness or insomnia, and diarrhea or constipation, weight gain, loss of libido. Most everything but the weight gain and loss of libido usually goes away within a couple of weeks. With Prozac (fluoxetine hydrochloride) it's a coin toss pros and cons of prozac as to losing or gaining weight. Sometimes it will just kill your appetite. For tips on how to cope with these side effects, please see our side effects page. These aren't all the side effects possible, just pros and cons of prozac the most popular ones. Not So Common Side Effects: Rash, 'flu-like symptoms, anger/rage. These may or may not happen to you don't, so don't be surprised one way or the other. Freaky pros and cons of prozac Rare Side Effects: Bleeding gums, amnesia, pros and cons of prozac anti-social reaction (oh, come on, like we're not anti-social already), herpes (again, blaming the med for pros and cons of prozac an STD), excessive hair growth, engorged breasts, involuntary tongue protrusion (in one 77-year-old woman who stopped sticking her tongue pros and cons of prozac out at everyone after they stopped giving her Prozac (fluoxetine hydrochloride)). You aren't going to get these. I promise. Interesting Stuff Your Doctor Probably Won't Tell You: Prozac (fluoxetine hydrochloride) has been found to make a lot of other drugs work better. pros and cons of prozac Great, huh? Not always, as with some meds it can be to the point of overdose. But it was that effect that lead to the breakthrough of the antipsychotic & antidepressant cocktail to treat bipolar depression. Anyway, Tegretol (carbamazepine) could suddenly get toxic pros and cons of prozac on you and Xanax (alprazolam) could knock pros and cons of prozac you out if you add Prozac (fluoxetine pros and cons of prozac hydrochloride) to them, or add them to Prozac (fluoxetine hydrochloride), so be careful and always check your drug-drug interactions! A big part of this is pros and cons of prozac the usual pharmacokinetic stuff of liver enzymes being pros and cons of prozac able to pros and cons of prozac deal with only so much, and Prozac (fluoxetine hydrochloride) gives your liver a bit of a pros and cons of prozac workout. But that doesn't explain the entire effect of all of the drug-drug interactions. There's some pharmacodynamic (how meds work in your brain) stuff going on as well.Prozac (fluoxetine hydrochloride) isn't such a hot idea for anyone with diabetes, and not because of potential weight gain, rather it messes with your glycemic control. Prozac's Dosage and How to Take Prozac: I'm just going to cover the dosages for adults. Even though Prozac (fluoxetine hydrochloride) is the only modern antidepressant approved for kids, with kids it's still a lot trickier. Depression - 20mg in the morning, increasing by 20mg a day after at least a week, taken either in the morning or at pros and cons of prozac noon until a maximum pros and cons of prozac of 80mg a day is reached. OCD & Bulima - 20mg in the pros and cons of prozac morning, increasing by 20mg a day after at least a week, taken either in the morning or at noon until a maximum of 60mg a day is reached. Panic - 10mg in the morning. Increase to 20mg, pros and cons of prozac either all in the pros and cons of prozac morning or split into morning and noon. Hold there for awhile before increasing. Although you can go up to 60mg a day, few people responded to anything above 20mg a day. Like any SSRI I recommend starting out with half the recommended dosage (except for Panic, that's pros and cons of prozac as low as you pros and cons of prozac can get) and then increasing to 20mg after a week. If you don't feel anything go up to 30mg, but stay there until you've given it a try for a month, otherwise it'll just be a pain in the ass to stop it. Even at 30mg you'll know after a month if it's going to do something for you. Prozac Weekly - You pros and cons of prozac just take the pros and cons of prozac one capsule a week for pros and cons of prozac everything. That's it. Days to Reach a Steady State: Four to five weeks.When you're fully saturated with the medication and less prone to peaks and valleys of effects. You still pros and cons of prozac might have peaks of pros and cons of prozac effect after taking many meds, but with a lot of the meds you'll have fewer valleys after this point. In theory anyway. How Long Prozac Takes to Work: Like all SSRIs anywhere from a couple days to over a month. If you don't feel any positive benefit after six weeks, then you should talk to your doctor about either another SSRI or trying a med that hits another neurotransmitter. Because of the long time it takes to reach a steady state, you might want to give Prozac (fluoxetine hydrochloride) a full two months. Just don't keep upping the dosage every week until then, otherwise it will be much harder and take much longer to stop taking Prozac. Prozac's Half-Life & Average Time to Clear Out pros and cons of prozac of Your System: Prozac (fluoxetine hydrochloride) pros and cons of prozac has the longest half-life of any med I've written up, 9.3 days. That's why there's such an animal as Prozac Weekly. Thus it takes 45 days to clear out of your system. How to Stop Taking Prozac: Your doctor should be recommending that you reduce your dosage pros and cons of prozac by 10-20mg a day every week pros and cons of prozac if you need to stop taking it, if not more slowly than that. For more information, please see the page on how to safely stop taking these crazy meds. Unlike other pros and cons of prozac medications, the time to step down from Prozac isn't pros and cons of prozac based on half-life, it's based on anecdotal evidence. In other words, people's experiences. Now, if you start to experience SSRI discontinuation syndrome once you're down around 30-40mg a day, then you will have to look at reducing your dosage by 10mg a day every month. But only if you're prone to the worst effects of discontinuation syndrome. pros and cons of prozac Which is unusual with Prozac (fluoxetine hydrochloride). Here's where you really have to balance the suckiness pros and cons of prozac of what you're dealing with in the way of side effects or whatever vs. SSRI discontinuation syndrome. And if you're taking Prozac Weekly you'll have to switch to the regular flavor to step down, as weekly is one size fits all. However, that extra-long half-life tends to make discontinuation less pros and cons of prozac harsh, so you'll probably be able to to get off of Prozac pros and cons of prozac (fluoxetine hydrochloride) a lot sooner. In fact switching to Prozac (fluoxetine hydrochloride) from another SSRI or Effexor (venlafaxine) is a good way of dealing with the discontinuation syndrome of the meds with the shorter half-lives. As Prozac comes in a liquid form, you can always switch to that to wean yourself off the last bit really slowly, pros and cons of prozac mg by mg. If you've worked your way up to a particular dosage, it's pros and cons of prozac usually best to spend this many days at the next lowest dosage before going down the next lowest dosage before that and so forth. This is the least sucky way to avoid problems when stopping any psychiatric medication. Presuming you have the option of slowly tapering pros and cons of prozac off them. How Prozac Works In Your Brain: Like all SSRIs Prozac (fluoxetine hydrochloride) doesn't make you produce more serotonin, rather it makes pros and cons of prozac your neurons soak for a longer period of time in the serotonin you already produce. Serotonin is one of the big three neurotransmitters responsible for depression, pros and cons of prozac along with norepinephrine and dopamine. My wild-ass guess / rule of thumb is that imbalances of pros and cons of prozac one or more of pros and cons of prozac the three are responsible for 80% of the depression issues. It's all just a matter of figuring out exactly the extent of the tweaking and what neurotransmitters you exactly need to tweak. Prozac (fluoxetine hydrochloride) is pros and cons of prozac the weakest of the SSRIs, and has the longest half-life, a combination that makes it the pros and cons of prozac best SSRI to start with and the only one approved for use with kids. Chances Prozac Will Work and How Prozac Compares to Other Meds: If you read the PI pros and cons of prozac sheet you'll just see that for Major Depressive Disorder Prozac (fluoxetine hydrochloride) produced a significantly higher rate of response and remission. But no hard numbers are given. Why? Because "significant" means somewhere in the neighborhood of 20%. That doesn't look to good. So you have about a 1 in 5 chance of it, or any SSRI, doing its job. Part of the problem is that serotonin isn't always the pros and cons of prozac issue with someone's depression. I'll be covering how to figure out which chemicals and/or voltage channels you need to pros and cons of prozac be tweaking in your brain in a future article to try to avoid the med-go-round. Another part of the low response rate is that sometimes these are the wrong meds entirely. SSRIs are for serious depression. Milder depression may require a milder medication, such as trazodone, or no medication at all. For OCD there are some hard numbers: TABLE 1 Outcome Classification (%) pros and cons of prozac on CGI pros and cons of prozac Improvement Scale for Completers in Pool of Two OCD Studies Prozac Outcome Classification Placebo 20 mg 40 mg 60 mg Worse 8% 0% 0% 0% No change 64% 41% 33% 29% Minimally improved 17% 23% 28% 24% Much improved 8% 28% 27% 28% Very much improved 3% 8% 12% 19% You can see for yourself what 40mg a day of Prozac (fluoxetine hydrochloride) will do. For pros and cons of prozac Panic/Anxiety two studies in the PI sheet with patients taking 20-60mg a day had 42% and 62% of the people taking Prozac (fluoxetine hydrochloride) being free from panic attacks at the end of 12 weeks. For PMDD, more hard numbers: TABLE 2 Percentage of Patients Moderately and Markedly Improved (>50% and 75% Reduction, Respectively, From Baseline Luteal Phase VAS Total Score) Improvement n Placebo n Fluoxetine 20 mg n Fluoxetine 60 mg Moderate 94 11% 95 37% 85 38% Marked 94 4% 95 6% 85 18% Finally for Bulima we get the same weasel wording as with pros and cons of prozac Major Depressive Disorder, "significant improvement." I'll be back with some comparisons pros and cons of prozac to other meds. Comments: First pros and cons of prozac approved by the FDA to treat depression in December of 1987.You know what can really suck? When pros and cons of prozac you've got someone who is all bipolar and hypersexual in a pros and cons of prozac relationship with someone who has Major Depressive Disorder and takes Prozac (fluoxetine hydrochloride) for it, only to have pros and cons of prozac her libido and all sexual response completely eliminated. pros and cons of prozac Can you spell "issues"? I knew pros and cons of prozac you pros and cons of prozac could. And in other Prozac (fluoxetine hydrochloride) experiences, Mouse was in the Clinical Trials for Prozac (fluoxetine hydrochloride), way back when it was the first SSRI in the US (Luvox (fluvoxamine maleate) predates it in Europe). If and when she feels up to it, pros and cons of prozac and pros and cons of prozac her memory pros and cons of prozac is together enough, she can report her side effects that give you the odds as to what your side effects will be. I'll bet folding money that hers was the anti-social reaction reported above. They probably couldn't believe that someone was that pros and cons of prozac anti-social pros and cons of prozac and it had pros and cons of prozac to be the drug that caused it. Prozac (fluoxetine hydrochloride) is pros and cons of prozac the only SSRI and modern antidepressant above for use for anyone under 18, and for good reason. Its long half-life makes compliance less of an issue. If your kid happens to pros and cons of prozac miss a day's dose now and then, it's not that big a deal. Whereas with Paxil (paroxetine hydrochloride) and Effexor (venlafaxine) missing doses for even one day can start the hell that is SSRI discontinuation syndrome, and they have the worst instances of it. pros and cons of prozac The syndrome is bad enough for adults, but would be beyond a nightmare for kids. See the SSRI page for more details on the vicious cycle kids can get pros and cons of prozac into and how Prozac (fluoxetine hydrochloride) avoids it with pros and cons of prozac its long half-life. Also by being the weakest of the SSRIs Prozac (fluoxetine hydrochloride) keeps kids from getting too much serotonin, which is also a huge problem. Serotonin syndrome is potentially fatal, and while giving kids a med like Paxil (paroxetine hydrochloride) is unlikely to be fatal in of itself, it will be suck-ass enough to cause the kids either start or ramp-up self-injurious or suicidal behavior because they are now feeling a hell of a lot worse from the pros and cons of prozac meds they're taking that everyone tells them are supposed to be making them feel better. Hell, even with adults Prozac (fluoxetine hydrochloride) is the best med to start with if serotonin is the prime suspect in the chemical imbalance for the very same reasons. While its side effects may suck more than the other SSRIs, pros and cons of prozac even for being the weakest SSRI on the market, if you're doing the med-go-round method of figuring out which way to fix your pros and cons of prozac brain (and that's still pretty much the standard way of doing it, unfortunately), trying Prozac (fluoxetine hydrochloride) first is the safest way to go. The discontinuation syndrome sucks so much less pros and cons of prozac with Prozac (fluoxetine hydrochloride). The risk of making things much worse is far lower with Prozac (fluoxetine hydrochloride). You have two ways to go when choosing your first SSRI: Fewer side effects and faster effect - then you want Lexapro (escitalopram oxalate). Less chance of just plain messing you up - you want Prozac (fluoxetine hydrochloride). Manufacturer: Eli Lilly Sample US Cost: $107 for 30 20mg capsules of brand-name Prozac or $42 for 30 20mg capsules of generic fluoxetine. As of 11/04/2003. Full retail for the uninsured. Go ahead and gloat, citizens of civilized countries and all of you with full medical pros and cons of prozac coverage. Sample Canadian Cost: $179 pros and cons of prozac for 100 20mg capsules of brand-name Prozac, $109 for 100 20mg capsules of generic fluoxetine. As of 11/04/2003. In US dollars, for re-importation to the US. Does not include shipping charges or currency conversion charges you might incur pros and cons of prozac on pros and cons of prozac your credit card. Currency fluctuations will alter the price on a daily basis. Remedy Find Rating for Depression Remedy Find Rating for Bipolar Check for Drug-Drug Interactions Full Patient/Prescribing/Physician Information Sheet Canadian Monograph from Internet Mental Health South African Lorien PI Sheet New Zealand Prozac-20 PI Sheet UK Oxactin PI Sheet UK Prozac PI Sheet Please see the section on how to read these pros and cons of prozac sheets. Don't freak out about every potential side effect. Look at the odds of something pros and cons of prozac having happened during the clinical pros and cons of prozac trials. Prozac in the pros and cons of prozac NewsThe Overlords of the 12 pros and cons of prozac Zernox Galaxies have compelled me through messages in the Sunday Chronicle to beg you for spare change. So if this site has been of use and/or amusement pros and cons of prozac to you, please see if you could or visit the Donation pros and cons of prozac Page if pros and cons of prozac PayPal isn't your style, or our Mental Mall to make a purchase. I'm all pros and cons of prozac about fiscal transparency, so follow the money pros and cons of prozac for full disclosure of my pitiful finances. Crazy Meds Home Crazy Boards - The Crazy Meds Online Forum & Chat Support Group Sites Sites with More Information About Crazy Meds Other Brand Names: Adofen (Spain) Alzac 20 (Guatemala) Andep (India) Ansilan (Colombia) Auroken (Mexico) Deprexin (Bahamas; Barbados; Belize; Bermuda; Curacao; Guyana; Jamaica; Dutch Antilles; Puerto Rico; Singapore; Surinam; Trinidad) Deproxin (Thailand) Fluctin pros and cons of prozac (Germany) Fluctine (Austria; Switzerland) Fludac (Benin; Burkina Faso; Ethiopia; Gambia; Ghana; Guinea; India; Ivory Coast; Kenya; Kuwait; Liberia; Libya Lebanon; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Oman; pros and cons of prozac Qatar; Republic of Yemen; Saudi Arabia; Senegal; Seychelles; Sierra Leone; South Africa; Sudan; Syria; Tanzania; Tunisia; Uganda; United Arab Emirates; Zambia; Zimbabwe) Flufran (India) Flunil (India) Fluox (Germany) Fluoxac (Mexico) Fluoxeren (Italy) Fluoxil (Dominican Republic) Fluox-Puren (Germany) Fluronin (Taiwan) Flusac (Thailand) Flutin (Colombia; Korea) Flutine (Israel; Thailand) Fluxen (Taiwan) Fluxetil (Singapore) Fluxetin (Singapore) Fluxil (Bahrain; Cyprus; Egypt; Hong Kong; Iran; Iraq; Israel; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic of Yemen; Saudi Arabia; Syria; United Arab Emirates) Fontex (Denmark; Finland; Norway; Sweden) Foxetin (Korea) Lanclic (Korea) Lorien (South Africa) Lovan (Australia) Magrilan (Singapore) Margrilan (Bahrain; Cyprus; Egypt; Hong Kong; Iran; Iraq; Jordan; Kuwait; Lebanon; Libya; Oman; Qatar; Republic of Yemen; Saudi Arabia; Syria; Thailand; United Arab Emirates) Modipran (Benin; Burkina Faso; Ethiopia; Gambia; Ghana; Guinea; pros and cons of prozac Ivory Coast; Kenya; Kuwait; Liberia; Libya Lebanon; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Oman; Qatar; Republic of Yemen; Saudi Arabia; Senegal; Seychelles; Sierra Leone; Sudan; Syria; Tanzania; Tunisia; Uganda; United pros and cons of prozac Arab Emirates; Zambia; Zimbabwe) Neupax pros and cons of prozac (Peru) Nopres (Indonesia) Nuzak (South Africa) Oxactin (United Kingdom) Oxedep (China; India) Pragmaten (Ecuador) Prizma (Israel) Proctin (Korea) Prodep (Benin; Burkina Faso; Ethiopia; Gambia; Ghana; Guinea; India; Ivory Coast; Kenya; Kuwait; Liberia; Libya Lebanon; Malawi; Mali; Mauritania; Mauritius; Morocco; Niger; Nigeria; Oman; Qatar; Republic of Yemen; pros and cons of prozac Saudi Arabia; Senegal; Seychelles; Sierra Leone; South Africa; Sudan; Syria; Tanzania; Tunisia; Uganda; United Arab Emirates; Zambia; Zimbabwe) Prozac 20 (Korea; Malaysia; Mexico; Philippines; Taiwan; Thailand) Rowexetina pros and cons of prozac (Costa Rica; Dominican Republic; El Salvador; Guatemala; Honduras; Nicaragua; Panama) Salipax (Bahamas; Barbados; Belize; Bermuda; Curacao; Guyana; Jamaica; Dutch Antilles; Puerto Rico; Surinam; Trinidad) Sanzur (South Africa) Sinzac (Taiwan) ZAC (Indonesia) Zactin (Australia; Singapore; Taiwan) Zepax (Colombia) Save $5 on McAfee VirusScan Online Save $5 on McAfee Privacy Services Take care, and keep taking your crazy meds! Jerod (click here to e-mail me, or just drop a note to jerod23 here at crazymeds.org) Hey, did you find this page all by itself through Google pros and cons of prozac or some other search engine? Great! But to really appreciate the entire site, you need to start here. Dead tree references: Healing Anxiety & Depression Daniel G. Amen, M.D., and Lisa C. Routh, pros and cons of prozac M.D. © 2003. Published by G.P. Putnam's Sons. Mouse and I are both patients at one of Dr. Amen's clinics. Instant Psychopharmacology 2nd Edition Ronald J. Diamond M.D. © 2002. Published by W.W. Norton Essential Psychopharmacology Stephen M. Stahl, M.D., Ph. D. © 2000. Published by Cambridge University Press A Primer of Drug Action Robert M. Julien, M.D., Ph. D. © 2001. We use the Ninth Edition. Sometimes that comes up on an Amazon search, usually it doesn't. Published by Worth Publishers Physicians' Desk Reference Editions 53 & 56 Maria Deutsch & Anu Gupta, Drug Information Specialists, et al. © 1999, 2002. Published by Medical Economics Company. pros and cons of prozac The pros and cons of prozac Complete Guide to Psychiatric Drugs Edward Drummond, M.D. © 2000. Published by John Wiley & Sons, Inc. Handbook of Affective Disorders edited by Eugene S. Paykel, M.D. FRCPsych © pros and cons of prozac 1992. Published by The Guilford Press. Mosby's 2004 Drug Guide David Nissen PharmD, Editor.© 2004. An pros and cons of prozac imprint of Elsevier. The edition we're using isn't pros and cons of prozac listed on Amazon. End of books used for this article. ---------------------------------------------------------------------------------------------------- Created Friday, November 07,2003 Last updated Tuesday, June 07, 2005 Copyright © 2003, 2004 Jerod Poore. All rights reserved. All material on this site is copyright © 2003, 2004 Jerod Poore. Except, of course, the PI sheets, that are the property of the drug companies who developed the drugs the sheets are about. And any documents that are written by other people pros and cons of prozac which may be posted to this pros and cons of prozac site pros and cons of prozac will remain the property of the original authors. This page and no other material may be reproduced off site outside of the boundaries of fair use copying without the express permission of pros and cons of prozac the copyright holder. That's usually me, so just ask first. All rights reserved. No warranty is expressed or implied in this information. Consult pros and cons of prozac one or more doctors and pharmacists before taking, or changing how you take any psychiatric medication. Your mileage may vary. What pros and cons of prozac happened to us won't necessarily happen to you. I am pros and cons of prozac neither a doctor pros and cons of prozac nor a pharmacist. pros and cons of prozac I pros and cons of prozac don't portray either here or on TV. Only a doctor can diagnose and treat an illness. Some doctors tend to get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself pros and cons of prozac in court, you suddenly have a fool for a doctor. Don't be pros and cons of prozac a cyberchondriac, thinking you have every disease you see a website about, or that you'll get every side effect from every medication. All information on this site has been obtained through personal experience, the experiences of my friends, the experiences of people reported on online support groups, and from sources that are referenced throughout the site. As such the information presented here is not a substitute for real medical advice from your real doctor, just a compliment to it. No psychiatrists pros and cons of prozac or pharmacists were harmed in the production of this website. All brand names of the drugs listed in this site are the trademarks of the companies listed after them in the pages about the drugs, even though those companies may or may not have been acquired by other pros and cons of prozac companies who may or may not be listed in this site by the time you read this. Always read the PI sheet that comes with your medications and never ever throw them away. If you didn't get a PI sheet, demand one. No pros and cons of prozac information about visitors to this site is collected or saved. Although from time to time I do look at search terms used to find it in an effort to make the information I present more relevant. Use only as directed. pros and cons of prozac Void where prohibited. "Everything is true, nothing is permitted." - Jerod pros and cons of prozac Poore Fluoxetine (Prozac, Sarafem) You are here:About>Health & Fitness>Depression> Depression Treatments> Medication> Medications A to Z> Names Beginning With "F"> Fluoxetine HomeEssentialsChats and ForumsScreening TestsDepression FAQDrug InformationAntidepressant Side-Effects Index Articles & ResourcesCauses of DepressionRelated Mental DisordersCoping SkillsAm I Depressed?Depression StatisticsGrief and LossDepression HelpDisability RightsDepression TypesTrue pros and cons of prozac Stories of DepressionSuicide and Self-InjuryDepression TreatmentsDrug Side-Effects Buyer's pros and cons of prozac GuideBefore You BuyTop PicksBest Gifts for the DepressedDepression Books for KidsDepression Books for Friends and FamilyProduct ReviewsArticlesForumsHelp FREE NewsletterSign Up Now for the Depression newsletter! See Online Courses SearchDepression Fluoxetine (Prozac, Sarafem) Resources dedicated pros and cons of prozac to the antidepressant Fluoxetine (Prozac, Sarafem). Articles & ResourcesSort By : Guide Picks | Alphabetical | Recent Up a category Prozac and PMS - What's in a Name?Mental Health Resources Guide Leonard Holmes reports on the "new" PMS drug Sarafem. Is this an attempt to get away from the negative press associated with the name Prozac? The Perils of Prozac - Part IPart I of a three part series examining the connection between pros and cons of prozac SSRIs and violence. Discusses recent trends in violence and news stories involving an SSRI pros and cons of prozac and a violent crime. pros and cons of prozac From your About.com Guide to Depression. The Perils of Prozac - Part IIPart II of a three part series examining the connection between SSRIs and violence. Discusses one woman's true experience and pros and cons of prozac what some experts say about Prozac pros and cons of prozac and violence. From your About.com Guide to pros and cons of prozac Depression. The Perils of Prozac - Part IIIPart II of a pros and cons of prozac three part series examining the connection between SSRIs and violence. Reviews prominent legal cases pros and cons of prozac involving SSRIs and lists several advocacy, support and information resources. From your About.com Guide to Depression. The Benefits Vs. the Risks of Taking Prozac during PregnancyWeighing the pros and pros and cons of prozac cons. One woman's mistake could pros and cons of prozac have proven fatal. From your About.com Guide to Depression. 8 more Articles & Resources below Articles pros and cons of prozac & Resources more from your guide Prozac (Fluoxetine) - OfficialDownload complete product information, including safety and effectiveness data, on this drug used in the treatment of depression. Prozac pros and cons of prozac (Fluoxetine) - PSYwebOffers advice on living with this serotonin-specific drug used to treat depression. Lists side effects, proper pros and cons of prozac dosage, pros and cons of prozac and cautions. Trial by ProzacPersonal page pros and cons of prozac of a man who suffers from depression and his experiences with Prozac. Includes discussion of the side effects he developed. Prozac DiaryOutlines an autobiographical book about a women pros and cons of prozac who overcomes her mental illness and becomes a Doctor of Psychology. The Prozac-Pez Web PagePEZ advocate claims that Prozac would be more effective if made available in similar candy dispensers. Read responses or play PEZ-Prozac game. ProzacNational Alliance for pros and cons of prozac the Mentally Ill supplies brief descriptions of Prozac's pros and cons of prozac benefits and risks FDA Approves Prozac For Seniors With pros and cons of prozac DepressionProzac becomes the first antidepressant approved for treatment of depression in the elderly. Prozac FAQQuestions and answers about Prozac. Includes Prozac during pregnancy, mixing Prozac and alcohol, loss of pros and cons of prozac sex drive while on Prozac, and others. About.com Opinion Polls - Be Heard! Which entrepreneur do you admire most? 1) Donald Trump 2) Richard Branson 3) Martha Stewart 4) Bill Gates 5) Oprah pros and cons of prozac Winfrey 6) None of Above What is the first pros and cons of prozac thing you pros and cons of prozac would do with 10 million dollars? 1) Spend it all 2) Donate to charities 3) pros and cons of prozac Invest 4) Pay bills 5) Save it all under my mattress 6) Not sure Which celebrity does more to promote the health of women? 1) Barbara Walters 2) Katie Couric 3) Oprah Winfrey 4) Susan Sarandon 5) Dr. Phil 6) None of Above Related Articles: Famous Entrepreneurs How To Become Wealthy Women's Health Top 10 SPECIAL OFFER for About Users: Save 50% off New York Times home delivery. Sign-up now! Topic Index | Email to a Friend Our Story | Be a Guide | Advertising Info | Work at About | Site Map | Icons | pros and cons of prozac HelpUser Agreement | Patent Info. | Privacy Policy | Kids' Privacy pros and cons of prozac Policy©2005 About, Inc. All rights reserved.Most PopularClinical Depression Screening QuizAnxiety Disorder - Anxiety Disorder Screening QuizDepression Test IZoloft (sertraline) Side-EffectsDepression pros and cons of prozac Test Index What's HotThe Perils of ProzacGotta Catch Some Zzzzzzzzz's!Marijuana and DepressionDepression Test IndexFAQ: Is Generic Fluoxetine as Good as Prozac Most Popular Video Bathroom Decoration Ideas Tag Sale Tips Creating a Craft Room Making a Personal Space Be Your pros and cons of prozac Own Contractor HeadlinesLunesta and Prozac Sepracor, a research-based pharmaceutical company, has continued testing Lunesta and..."War of the Worlds" Boycott Will you be boycotting Tom Cruise's new movie "War pros and cons of prozac of...Poll: How Well Do You Sleep? Sleep and mood are intimately related. How well do you...How to Beat Insomnia Sleep deprivation can leave you feeling irritable and depressed. Tips... 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It pros and cons of prozac was the first of a class of antidepressants known as selective serotonin re-uptake inhibitors, or SSRIs, which quickly became the most common treatment for depression. Seventy percent of patients got relief with the first drug they were prescribed. SSRIs (among them Prozac, Paxil and Zoloft) work by targeting serotonin, one of the chemicals that help the neurons pros and cons of prozac involved in the mood-regulating system of the brain to pros and cons of prozac communicate with each other. The impact that these medications pros and cons of prozac have on people's moods, the way they perceive things, and their ability to enjoy life has led researchers to believe that thoughts, perceptions and feelings are rooted to a surprising degree in the brain's biochemistry. Serotonin, most researchers believe, is particularly important in regulating mood, pros and cons of prozac and depressives appear to have too little of it. By making more available, SSRIs relieve the patient's symptoms. Still, serotonin affects more than mood -- it influences everything pros and cons of prozac from sexual behavior to digestion. Researchers have begun sorting out the many different receptors that are involved in serotonin's various functions, and in an effort to reduce side effects, pros and cons of prozac they are homing in ever more tightly on those receptors that affect only mood. SSRIs are a major improvement over previous antidepressants -- the tricyclics and monoamine oxidase inhibitors (MAOIs). The older drugs aren't as targeted, altering the levels of many different brain chemicals, including dopamine and norepinephrine. As a result, these drugs, though equally effective as SSRIs, influence a wider range of brain functions and spawn a wider range of side effects. More important, both can be deadly if the patient overdoses. SSRIs are unlikely to be pros and cons of prozac deadly pros and cons of prozac even with an overdose. But the new wave of antidepressants have fallen far short of ending depression in our time. As many pros and cons of prozac as 30 percent of pros and cons of prozac patients respond to the medications only partially or not at all. Some find that the drugs' effectiveness begins to wane over time; still more can't bear the side effects: SSRIs can cause jitteriness, sexual dysfunction, headaches, sleep problems and weight changes. They can be dangerous when taken in combination with MAOIs. (One of the newest drugs on the market, Celexa, eliminates some of the side effects by being even more selective in targeting serotonin receptors.) PAGE 8 OF 9 NEXT: Managing Depression pros and cons of prozac in this article PAGE 1: The pros and cons of prozac Elusive Affliction pros and cons of prozac PAGE 2: Causes of Depression PAGE 3: Treatment Choices PAGE 4: Depression's Grip PAGE 5: How to Know PAGE 6: The Road to Wellness PAGE 7: Therapy vs. Medication PAGE 8: Antidepressants: The Pros and Cons PAGE 9: Managing Depression printer friendly version Subscribe to Town & Country related links SUBSCRIBE: Get more of what you want from Town & CountryClick for details ARTICLE: High Anxiety ARTICLE: Depression: A Glossary of Terms ARTICLE: Advice From the Front Lines ARTICLE: When It's Your Partner ARTICLE: Descent Into Hell pros and cons of prozac USA: 12 issues for $12 • pros and cons of prozac Non-USA: click here name Address 1 Address 2 city state zip Email Yes, please send me special offers and promotions pros and cons of prozac from Hearst Magazines (privacy policy) SUBSCRIBE NOW AND BILL ME LATER Offer pros and cons of prozac good in the U.S. only. 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