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Normal Lasix Renogram Normal Nuclear lasix renogram Renogram After the lasix renogram venous injection of radioisotope, images are collected over three minute lasix renogram intervals. DTPA is one of four types of radionuclide agents used in imaging of the kidney. It is filtered through the glomerulus so it is useful in detecting perfusion of the kidney and glomerular filtration. It does not demonstrate function of the renal tubules. The images are read from left to right and from top to bottom. Note lasix renogram that, unlike x-rays, nuclear renograms show the left kidney on lasix renogram the lasix renogram left side lasix renogram (as lasix renogram you face the scan). The data collected by the camera is analyzed by a computer and plotted on a time graph. lasix renogram Counts (how much isotope is in the kidneys) lasix renogram is shown on the Y axis and time from injection is shown on lasix renogram the X lasix renogram axis. The response of each kidney is plotted separately. Notice that both lasix renogram kidneys take up the isotope rapidly (the curves are steeply rising between lasix renogram 1 and 3 minutes). The concentration lasix renogram of lasix renogram the isotope peaks at 4-6 minutes and then starts to fall. lasix renogram Normally at least half of lasix renogram the isotope is excreted and drained from lasix renogram the kidneys within 20 lasix renogram minutes. When obstruction is suspected, a diuretic is given 15 minutes after lasix renogram injection lasix renogram of the isotope to increase urine production. This will wash the isotope out of an enlarged kidney pelvis as long as there is lasix renogram no obstruction to urine flow into the lasix renogram bladder. See a scan showing obstruction. Return lasix renogram to G/U Imaging Home Page. Return to G/U Development Home Page. ©David A. Hatch, M.D., 1996 kidney obstruction Questions in the Urology Forum lasix renogram have been answered by Dr. Kevin Pho, (who is lasix renogram board certified in Internal Medicine) and by urologists from Henry Ford Health System. Forum: The Urology Forum Topic: Pediatric Urology Subject: kidney obstruction Our son born 8-24- 98 was diagnosed with mild hydronephrosis in utero. since then, reflux has been ruled out, but lasix renogram the lasix renogram lasix renogram showed moderate obstruction of the right and mild of the lasix renogram left kidney. the obstruction appeared at the kidney ureter junction. percentage was 38% right and 62% left. recommendations were moniter every three months with lasix renogram and operate if recurring infection or lasix renogram kidney lasix renogram damage becomes evident. I have read information from another ped urologist that early surgery was recommended that lasix renogram would lasix renogram return any lost kidney function and take the compensatory pressure off the left kidney. this seem contradictory. I would appreciate any suggestions. Also he incidentally was born with very mild hypospadia and chordee. thank you for lasix renogram you time and lasix renogram informaiton===========================================================================Dear Mike Thanks for your questions.Bilateral hydronephrosis secondary to bilateral UPJ obstruction is rare. The verdict is still out with regards to early/ late operation verse observation for UPJ obstructions. Dr. King et al ,in lasix renogram 1984, recommend early surgery. Dr. Ransley et al , 1990, recommend surgery if lasix renogram function in one lasix renogram of the renal units is less lasix renogram than 40% and lasix renogram Drs. Koff and Campbell, 1992 recommend lasix renogram observation only.. lasix renogram Multiple genitourinary abnormalities are more common when at lasix renogram least one is present. More individualized lasix renogram care lasix renogram is available at the Henry Ford Hospital and its urban campuses by calling (1 800 653 6568). We can also arrange local accommodations through this number lasix renogram if this is your need. lasix renogram Please bring any physicians’ notes and lab test results that you may be able to obtain. These will help us greatly.This information lasix renogram is provided for general lasix renogram medical education purposes only. Please consult your physician for diagnostic and treatment options pertaining to your specific medical condition. Sincerely;HFHS-M.D. MS* Keyword: hydronephrosis, ureteropelvic junction obstruction, surgical treatment for ureteropelvic junction obstruction Reply by: HFHS M.D.-MS on lasix renogram 01/21/1999 [Urology Forum ] [Urology Archives] [ Med Help International ] Copyright © Med Help International. All rights reserved. Diuresis Renogram Joint Program in Nuclear Medicine Diuresis Renogram Chandra Dass, MD  Finn Mannting, MD PhD November 26, 1996 Presentation A 28 year lasix renogram old female with a six year history of left flank pain occuring mostly while lying down, was discovered by pelvic ultrasound to have left hydronephrosis. An intravenous urogram revealed normal right kidney lasix renogram and the left kidney revealed mild to moderate dilatation of the intrarenal collecting system upto the level of the UPJ, that was most likely congenital. Blood chemistry was within normal lasix renogram limits. Imaging Findings A MAG-3 Lasix Renogram was performed and showed prompt excretion of activity from lasix renogram the right kidney, but an obstructed pattern on the left side (shown on time-activity curves from a region-of-interest over the collecting system). There was lasix renogram symetric renal lasix renogram function. Follow lasix renogram Up The patient lasix renogram underwent a left pyeloplasty, and lasix renogram has been asymptomatic since. Discussion Urinary tract obstruction is a very common lasix renogram problem that, if untreated, may lead to progressive renal damage. Acute obstruction is diagnosed clinically and by radiological lasix renogram techniques. Uptake of radioactive tracer varies from no uptake at all to lasix renogram normal uptake depending on the pressure build-up in the obstructed lasix renogram collecting system and time. Radionuclide function measurements have limited prognostic value in acute obstruction. Chronic obstruction leads to the compromise of renal function. Radiologic techniques (excretory and retrograde urogram), lasix renogram CT and lasix renogram US accurately define the anatomy of the involved portion of the urological tract and the pathology of the lesion but not the functional lasix renogram status of the individual kidneys lasix renogram in a simple quantitative manner. The flow, uptake, and excretion of tracers accurately reflect the functional status of each kidney lasix renogram and are used lasix renogram to follow the renal function after therapeutic interventions. Invasive testing often lasix renogram may be necessary to predict the functional recovery (1). From the use of antegrade perfusion pressure flow test (Whitaker test), it became clear that dilated systems lasix renogram are not always obstructed, and this differentiation is clinically relevent in the further patient management. Whitaker test, though not dependent on renal function, is invasive and provides no information about the functional status of the kidneys. Diuretic renogram is noninvasive, provides lasix renogram functional information, but very poor renal lasix renogram function may invalidate the study since test results depend on tracer uptake lasix renogram followed by diuresis induced washout (2). Tubular agents are preferred and currently Tc99m MAG - 3 is widely used for its lasix renogram high extraction fraction, rapid parenchymal transit, low radiation absorbed dose and excellent imaging properties. lasix renogram The standard acquisition parameters used are LFOV lasix renogram camera with LEAP collimator, 128 lasix renogram x 128 matrix in 10-30 sec / frames, displayed as 2-5 min images. Time activity curves are generated lasix renogram (Renogram Phase: Whole lasix renogram kidney ROI and 2 pixel lasix renogram thick ring around kidney for background; Diuretic Phase: Renal pelvis ROI and infero-lateral ellipse for background) after background subtraction. Differential function is calculated from the 1-2 min interval data with lasix renogram tubular agents. The recommended dose of furosemide (Lasix) in adults is 40 mg iv. In the standard protocol, Lasix is injected when the collecting system appears to be full (usually 15-20 min after tracer injection, called F +20). In patients with equivocal results, lasix renogram a second study with lasix renogram administration of Lasix 15 min before tracer injection (called F -15) is performed to maximise the diuretic stress which improves the sensitivity, specificity lasix renogram and reduces the chances of equivocal outcome (3,4). Quantitative parameters like time to peak (TTP), 20 min to peak activity ratio (20/MAX), pelvic T1/2 clearance time, parenchymal transit lasix renogram time lasix renogram (PTT) are lasix renogram valuble adjuvants (5). The lasix renogram significance of the time-activity response patterns is based on correlations with both surgical results and long term clinical-follow-up. The literature is replete with attempts to refine and quantify response patterns. Conservatively, the diuresis renogram should be lasix renogram taken as only one indicator of drainage function. It lasix renogram has limitations. The results of diuretic renogram are affected by several factors: the urine flow rate (depends on renal function & level of hydration), large volume collecting system, increased pelvic compliance, rigid pelvis, immature kidney, degree of obstruction lasix renogram etc (2). Several attempts are made to standardize these variables in an ongoing effort to improve test accuracy (6,7,8,9). Presently, diuretic renography is recommended as the initial screening study in patients found on urography or US to have dilated upper urinary tract lasix renogram without obvious lasix renogram cause (equivocal obstruction). It is also lasix renogram used in patients to determine the clinical significance of a known partial obstruction. It is well tolerated, easily repeatable, and lasix renogram appropriate for pediatric patients also. In patients with very poor renal function, patients with very dilated upper urinary tract or patients with equivocal diuretic renogram, Whitaker test can be useful and these tests should be regarded as complementary rather than competitive in evaluating equivocal obstruction lasix renogram (10). References 1. Dubovsky E, Russell C. In Principles of Nuclear Medicine. Wagner H, Szabo Z, lasix renogram Buchanan lasix renogram J (eds), W.B lasix renogram Saunders Company, Philadelphia, PA, 1995. pp lasix renogram 977-978. 2. McBiles II M, Lambert A, lasix renogram Cote M, et al. Diuretic scintigraphy. Past, Present and Future. Nucl Med Ann 1995;pp185-216. 3. Upsdell SM, Testa HJ, lasix renogram Lawson RS, et al. Diuretic induced urinary flow rateat varying clearances lasix renogram and their relevance to the performance and interpretation of diuresis renography. Br J Urol 1988;61:14-18. 4. lasix renogram English PJ, Testa HJ, Lawson RS, lasix renogram et al. Modified method of diuresis renography for assesment of equivocal pelviureteric junction obstruction . Br J Urol 1987;59:10-14. 5. Britton KE, Nawaz lasix renogram MK, Whitfield HN, et al. Obstructive uropathy: Comparision between parenchymal transit time index and frusemide diuresis. Br J Urol 1987; 59: 127-132. 6. Conway JJ: Well-tempered diuresis renography: Its historical development, physiologic and thechnical pitfalls, and standardized technique protocol. Semin Nucl Med 1992;22:74-84. 7. Society of Nuclear Medicine. The "Well tempered" diuretic renogram: A standard method lasix renogram to examine the asymptomatic neonate with hydronephrosis or hydroureteronephrosis. J Nucl Med 1992;33:2047-2051. 8. O'Reilly PH. Diuresis lasix renogram renography. Recent advances and recommended protocols. Br J Urol.1992;69:113-120. 9. Consensus on Diuresis Renography for investigating the dilated upper urinary tract. O'Reilly PH, Aurell M, lasix renogram Britton K, et al. J Nucl Med 1996; 37:1872-1876. 10. O'Reilly PH, George, Weiss lasix renogram (eds). In Diagnostic Techniques in Urology. W.B. Saunders Company;1990:pp 401-425. Click here to go to Joint Program in Nuclear Medicine home page and Copyright notice.  J. Anthony Parker, MD PhD, Tony_Parker@bidmc.harvard.edu Clinical Nuclear Medicine - userLogin LWWOnline  |  LOGIN  |  eALERTS  |  REGISTER  |  CUSTOMER SUPPORT   Home Search Current Issue Archive You are attempting to access protected content. To access this content please login using lasix renogram an established account or create/activate an account.   Login: lasix renogram subscribers, members & guests If you have already created/ activated an online account, please login below: User Name:     Password:                          Note: passwords are CASE SENSITIVE   Activate/Register: new lasix renogram users & lasix renogram guests If you are a lasix renogram new user or guest visiting lasix renogram an LWWonline site for the first time, please complete the new account setup process to lasix renogram view or purchase content. Login Help & Resources Forgot your password? Subscribe Renewal Information Copyright lasix renogram © 2005, Lippincott Williams & Wilkins. All rights reserved. Published by Lippincott Williams & Wilkins. Copyright/Disclaimer Notice • Privacy Policy folsomRelease 3.0.0
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