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| lasix furosemide cheap lasix lasix renal scan lasix eye surgery maryland lasix online lasix for cat eye lasix surgery washington salem lasix eye lasix salem surgery eugene lasix lasix 40mg lasix special lasix vision correction miami lasix eye lasix allergy lasix injection lasix sale | lasix Lasix Overdose, Contraindications and Information - Furosemide - RxList Monographs Furosemide • New Safety Warning for Psoriasis Drug Raptiva • lasix contraindications Company Issues Pacemaker Malfunction Warning • Deaths Seen With Fentanyl Narcotic Pain Patch OVERDOSE The principal signs and symptoms of overdose with furosemide are dehydration, lasix contraindications blood volume reduction, hypotension, electrolyte imbalance, hypokalemia and hypochloremic alkalosis, and are lasix contraindications extensions of its diuretic action. The acute toxicity of furosemide has been determined in mice, rats and dogs. In all three, the oral LD50 exceeded lasix contraindications 1000 mg/kg body weight while the intravenous LD50 ranged from 300 to 680 mg/kg. The acute intragastric toxicity in neonatal rats lasix contraindications is 7 to 10 times that of lasix contraindications adult rats. The concentration of furosemide in biological fluids associated with toxicity or death is not known. Treatment of overdosage is supportive and consists of replacement of excessive fluid and electrolyte losses. Serum electrolytes, lasix contraindications carbon dioxide level and blood pressure should be determined frequently. Adequate drainage must be assured lasix contraindications in patients with urinary bladder outlet obstruction (such as prostatic hypertrophy). Hemodialysis does not accelerate furosemide elimination. CONTRAINDICATIONS Furosemide is contraindicated in patients with anuria and in patients with a history of hypersensitivity to furosemide. This Page Last lasix contraindications Updated 12/08/2004 Copyright © 2004 by RxList Inc. Lasix Patient, Information, Instructions - Furosemide - RxList Monographs lasix contraindications Furosemide • New Safety Warning for Psoriasis Drug Raptiva • Company Issues lasix contraindications Pacemaker Malfunction Warning • Deaths lasix contraindications Seen With Fentanyl Narcotic Pain Patch PATIENT INFORMATION Furosemide is a diuretic (water pill) used to treat fluid retention and high blood pressure. Do not take this medication if you are allergic to sulfa medicine. Notify your lasix contraindications physician if you are pregnant or nursing. Notify your physician if you have diabetes mellitus. Blood glucose levels may be increased in patients with diabetes mellitus. Take this medication early in the lasix contraindications day. lasix contraindications Furosemide may be taken with or without food. Take with food or milk if stomach upset occurs. Notify your physician if you develop weakness, cramps, or nausea. Dizziness or lightheadedness may occur with therapy; avoid sudden changes in posture. Furosemide may cause increased sensitivity to sunlight. Use sunscreens and wear protective clothing lasix contraindications until degree of sensitivity is determined. lasix contraindications This Page Last Updated 12/08/2004 Copyright © 2004 by RxList Inc. Lasix Prescribing Information as of January 2004 - Aventis Pharmaceuticals Rev. January 2004 LASIX® (furosemide) Tablets lasix contraindications 20, 40, and 80 mg View Acrobat PDF WARNING DESCRIPTION CLINICAL PHARMACOLOGY INDICATIONS AND USAGE lasix contraindications CONTRAINDICATIONS WARNINGS PRECAUTIONS ADVERSE REACTIONS OVERDOSAGE DOSAGE AND ADMINISTRATION HOW SUPPLIED WARNING LASIX® (furosemide) is a potent diuretic which, if lasix contraindications given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. lasix contraindications Therefore, careful medical supervision is required and dose and dose schedule must be adjusted to the individual patient’s needs. (See DOSAGE AND ADMINISTRATION.) TOP DESCRIPTION LASIX® is a diuretic which is an anthranilic acid derivative. LASIX tablets lasix contraindications for oral administration contain furosemide as the active lasix contraindications ingredient and the following inactive ingredients: lactose lasix contraindications monohydrate NF, magnesium stearate NF, starch NF, talc USP, and colloidal silicon dioxide NF. lasix contraindications Chemically, it is 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid. LASIX is available as white tablets for lasix contraindications oral administration in dosage strengths of 20, 40 and 80 mg. Furosemide lasix contraindications is a white to off-white odorless crystalline powder. It is practically insoluble in water, lasix contraindications sparingly soluble in alcohol, freely soluble in dilute alkali solutions and insoluble in dilute acids. The CAS Registry Number is 54-31-9. The structural formula is as follows: TOP CLINICAL PHARMACOLOGY Investigations into the mode of action of LASIX have utilized micropuncture studies in rats, stop flow experiments in dogs lasix contraindications and various lasix contraindications clearance studies in both humans and experimental animals. It has been demonstrated that LASIX inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubules but also lasix contraindications in the loop of Henle. The high degree of efficacy is largely due to the unique site of action. lasix contraindications The action on the distal lasix contraindications tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone. Recent evidence suggests lasix contraindications that furosemide glucuronide is lasix contraindications the only or at least the major biotransformation product of furosemide in man. Furosemide is extensively bound to plasma proteins, mainly to albumin. Plasma concentrations ranging from 1 to 400 mg/mL are 91 to 99% bound lasix contraindications in healthy individuals. The unbound fraction averages 2.3 to 4.1% at therapeutic concentrations. The onset of diuresis following oral administration is within 1 hour. The peak effect occurs within the first or second hour. The duration of diuretic effect is lasix contraindications 6 to 8 hours. In fasted normal men, the mean bioavailability of furosemide lasix contraindications from LASIX lasix contraindications Tablets and LASIX Oral Solution is 64% and 60%, respectively, of that lasix contraindications from an intravenous lasix contraindications injection of the drug. Although furosemide is lasix contraindications more rapidly absorbed from the oral solution (50 minutes) than from the tablet (87 minutes), peak plasma levels and area under the plasma concentration-time curves do not differ significantly. Peak plasma concentrations increase with increasing dose but times-to-peak do not differ among doses. The terminal half-life of furosemide is approximately lasix contraindications 2 hours. Significantly more furosemide is excreted in urine following the lasix contraindications IV injection than after the tablet or oral solution. There are no significant differences between the two oral formulations in the amount of unchanged drug excreted in urine. TOP INDICATIONS AND USAGE Edema LASIX is indicated in adults lasix contraindications and pediatric patients for the treatment of edema associated with congestive lasix contraindications heart failure, cirrhosis of the lasix contraindications liver, and renal disease, including the nephrotic syndrome. LASIX is particularly useful lasix contraindications when an agent with greater diuretic lasix contraindications potential is desired. Hypertension Oral LASIX may be used lasix contraindications in adults for the treatment of hypertension alone or in combination with other antihypertensive agents. Hypertensive patients who cannot be adequately controlled with thiazides will probably also not lasix contraindications be adequately controlled with LASIX alone. TOP CONTRAINDICATIONS LASIX is contraindicated in patients with anuria and in patients with a history of hypersensitivity to furosemide. TOP WARNINGS In patients with hepatic cirrhosis and ascites, LASIX therapy is best initiated in the hospital. In lasix contraindications hepatic coma and in states of electrolyte depletion, therapy should not be instituted until the basic condition is improved. Sudden alterations of fluid and electrolyte balance in patients with cirrhosis may precipitate hepatic lasix contraindications coma; lasix contraindications therefore, strict observation is necessary during the period of diuresis. Supplemental potassium chloride and, if required, an aldosterone antagonist are helpful in preventing hypokalemia and metabolic alkalosis. If increasing azotemia and oliguria occur during treatment of severe progressive renal disease, LASIX should be discontinued. Cases of tinnitus and reversible lasix contraindications or irreversible hearing impairment have been reported. Usually, reports indicate lasix contraindications that LASIX ototoxicity is associated with rapid injection, severe renal impairment, doses exceeding several times the usual recommended dose, or concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs. If the physician elects to use high dose parenteral therapy, controlled intravenous lasix contraindications infusion is advisable (for adults, an infusion rate not exceeding 4 mg LASIX per minute has been used). TOP PRECAUTIONS General lasix contraindications Excessive diuresis may cause dehydration and blood volume reduction with circulatory collapse and possibly vascular thrombosis and embolism, particularly in elderly patients. As lasix contraindications with any effective diuretic, electrolyte depletion may occur during lasix contraindications LASIX therapy, especially in patients lasix contraindications receiving higher doses and a restricted salt intake. Hypokalemia may develop with LASIX, especially with brisk diuresis, inadequate oral electrolyte intake, when cirrhosis is present, or during concomitant use of corticosteroids or ACTH. Digitalis therapy may exaggerate metabolic effects of hypokalemia, especially myocardial effects. All patients receiving LASIX therapy should be observed for these signs or symptoms of fluid or electrolyte imbalance (hyponatremia, hypochloremic alkalosis, hypokalemia, hypomagnesemia or hypocalcemia): dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, arrhythmia, lasix contraindications or gastrointestinal disturbances such as nausea and vomiting. Increases lasix contraindications in blood glucose and alterations in glucose tolerance tests (with abnormalities of lasix contraindications the fasting lasix contraindications and 2-hour postprandial sugar) have been observed, and rarely, precipitation of diabetes mellitus has been reported. Asymptomatic hyperuricemia lasix contraindications can occur and gout may rarely be precipitated. Patients allergic to sulfonamides may also be allergic to LASIX. The possibility exists of exacerbation or activation of systemic lasix contraindications lupus erythematosus. As with many other drugs, patients should be observed lasix contraindications regularly for the possible occurrence of lasix contraindications blood dyscrasias, liver or kidney damage, or other idiosyncratic reactions. Information for Patients Patients receiving LASIX should be lasix contraindications advised that they may experience symptoms lasix contraindications from excessive fluid and/or electrolyte losses. The postural lasix contraindications hypotension that sometimes occurs can lasix contraindications usually be managed by getting up slowly. Potassium supplements and/or dietary measures may be needed to control or avoid hypokalemia. Patients lasix contraindications with diabetes mellitus lasix contraindications should be told that furosemide may increase blood lasix contraindications glucose levels and thereby affect urine glucose tests. The skin of lasix contraindications some patients may be more sensitive to the effects of sunlight while taking furosemide. Hypertensive patients should avoid medications that may increase blood pressure, including over-the-counter products for appetite suppression and cold symptoms. Laboratory Tests Serum electrolytes (particularly potassium), CO2, creatinine and BUN should be determined frequently during the first few months of LASIX therapy and periodically thereafter. Serum and urine electrolyte determinations are particularly important when the patient is vomiting profusely or receiving parenteral fluids. Abnormalities should be corrected or the drug temporarily withdrawn. Other medications may also lasix contraindications influence serum electrolytes. Reversible elevations of BUN may occur and are associated with dehydration, which should be avoided, particularly in patients with renal insufficiency. Urine and blood glucose should be checked periodically in diabetics receiving lasix contraindications LASIX, even in those suspected of latent diabetes. LASIX may lower serum levels of calcium (rarely cases of tetany have been reported) and magnesium. Accordingly, lasix contraindications serum levels of these electrolytes should be determined lasix contraindications periodically. Drug Interactions LASIX may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function. Except in life-threatening situations, avoid this combination. LASIX should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity. lasix contraindications Patients receiving high doses of salicylates lasix contraindications concomitantly with LASIX, as lasix contraindications in rheumatic disease, may lasix contraindications experience salicylate lasix contraindications toxicity at lower doses because of competitive renal lasix contraindications excretory sites. LASIX has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine. Lithium generally should not be given with diuretics because they reduce lithium’s renal clearance and add a high risk of lithium toxicity. LASIX may add to lasix contraindications or potentiate the therapeutic effect of other antihypertensive drugs. Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs. LASIX may decrease arterial responsiveness to norepinephrine. However, norepinephrine may still lasix contraindications be used effectively. Simultaneous administration of sucralfate and LASIX lasix contraindications tablets may reduce lasix contraindications the natriuretic and antihypertensive effects of LASIX. Patients receiving both drugs should be observed closely to determine if the desired diuretic and/or antihypertensive effect of LASIX lasix contraindications is achieved. The intake of LASIX and sucralfate should be separated by at least two hours. One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine lasix contraindications clearance in patients with chronic renal insufficiency. There are case reports of patients who developed increased BUN, lasix contraindications serum lasix contraindications creatinine and lasix contraindications serum potassium levels, and weight gain when furosemide was used in conjunction lasix contraindications with NSAIDs. Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of LASIX (furosemide) in some patients by inhibiting prostaglandin synthesis. Indomethacin may lasix contraindications also affect plasma renin levels, aldosterone excretion, and lasix contraindications renin profile evaluation. Patients receiving both indomethacin and lasix contraindications LASIX should be observed closely to determine if the desired diuretic and/or antihypertensive effect of LASIX is achieved. Carcinogenesis, Mutagenesis, Impairment of lasix contraindications Fertility Furosemide lasix contraindications was tested for carcinogenicity by oral administration in lasix contraindications one lasix contraindications strain lasix contraindications of mice and one strain of rats. A small but significantly increased lasix contraindications incidence of mammary gland carcinomas occurred in female mice at a dose 17.5 times the maximum human dose of 600 mg. There were marginal increases in uncommon tumors in male rats at a dose of 15 mg/kg (slightly greater than the maximum human dose) but not at 30 mg/kg. Furosemide was devoid of mutagenic activity in various strains lasix contraindications of Salmonella typhimurium lasix contraindications when tested in the presence or absence of an in vitro metabolic activation lasix contraindications system, and questionably positive for gene mutation in mouse lymphoma cells lasix contraindications in the presence of rat liver S9 at the highest dose tested. Furosemide did not induce sister chromatid exchange in human cells in vitro, lasix contraindications but other studies on chromosomal aberrations in human cells in vitro gave conflicting results. In Chinese hamster cells it lasix contraindications induced chromosomal damage but was questionably positive for sister chromatid exchange. Studies on the induction by furosemide of chromosomal aberrations in mice were inconclusive. The urine of rats treated with this drug did not induce gene conversion in Saccharomyces cerevisiae. LASIX (furosemide) produced no impairment of fertility in male or female lasix contraindications rats, at 100 mg/kg/day (the maximum effective diuretic dose lasix contraindications in the rat and 8 times the lasix contraindications maximal human dose of 600 mg/day). Pregnancy PREGNANCY CATEGORY C-Furosemide has been shown to cause unexplained maternal deaths and abortions in lasix contraindications rabbits at 2, 4 and 8 times the maximal recommended human dose. There are no adequate and well-controlled studies in pregnant women. LASIX should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. The effects lasix contraindications of lasix contraindications furosemide on embryonic and fetal development and on pregnant dams were studied lasix contraindications in mice, rats and rabbits. Furosemide caused unexplained maternal deaths and lasix contraindications abortions in the rabbit lasix contraindications at the lowest dose of 25 mg/kg (2 times the maximal recommended human dose of 600 mg/day). In another study, a dose of 50 mg/kg (4 times the maximal recommended human dose of 600 mg/day) also caused maternal deaths and abortions when administered to rabbits between Days 12 and 17 of gestation. In a third study, none of the pregnant rabbits survived a dose of 100 mg/kg. Data from the above studies indicate fetal lethality that can precede maternal deaths. The results lasix contraindications of the mouse study and lasix contraindications one of the three rabbit studies lasix contraindications also showed an increased incidence and severity of hydronephrosis (distention of the renal pelvis and, in some cases, of the ureters) in fetuses derived from the treated dams as compared with the incidence in fetuses from the control group. Nursing Mothers Because it appears in breast milk, caution should be exercised when LASIX is administered to a nursing mother. TOP ADVERSE REACTIONS Adverse reactions are categorized below by organ system and listed by decreasing severity. Gastrointestinal System Reactions 1. lasix contraindications pancreatitis 5. cramping 2. jaundice lasix contraindications (intrahepatic cholestatic jaundice) 6. diarrhea 3. anorexia lasix contraindications 7. constipation 4. oral and gastric irritation 8. nausea lasix contraindications 9. vomiting Systemic Hypersensitivity Reactions lasix contraindications 1. systemic vasculitis 3. necrotizing angiitis 2. interstitial nephritis Central Nervous System Reactions lasix contraindications 1. tinnitus lasix contraindications and hearing loss 4. dizziness 2. lasix contraindications paresthesias 5. headache 3. vertigo 6. blurred lasix contraindications vision lasix contraindications 7. xanthopsia Hematologic Reactions lasix contraindications 1. aplastic anemia (rare) 4. hemolytic anemia 2. thrombocytopenia 5. leukopenia 3. agranulocytosis (rare) 6. anemia Dermatologic-Hypersensitivity Reactions 1. lasix contraindications exfoliative dermatitis 5. urticaria 2. erythema multiforme 6. lasix contraindications rash 3. purpura 7. pruritus lasix contraindications 4. photosensitivity Cardiovascular Reaction Orthostatic hypotension may occur and be aggravated by alcohol, barbiturates or narcotics. Other lasix contraindications Reactions 1. hyperglycemia 6. restlessness 2. lasix contraindications glycosuria 7. lasix contraindications urinary bladder spasm 3. hyperuricemia 8. thrombophlebitis lasix contraindications 4. muscle spasm 9. fever 5. lasix contraindications weakness Whenever adverse reactions are moderate or severe, LASIX dosage should be reduced or therapy lasix contraindications withdrawn. lasix contraindications TOP OVERDOSAGE The principal signs lasix contraindications and symptoms of overdose with LASIX are dehydration, lasix contraindications blood volume lasix contraindications reduction, hypotension, electrolyte imbalance, hypokalemia and hypochloremic alkalosis, and are extensions of its diuretic action. The acute toxicity of LASIX has been determined in mice, rats lasix contraindications and dogs. In all three, the oral LD50 exceeded 1000 mg/kg body weight, while the intravenous LD50 ranged from 300 to 680 mg/kg. The acute intragastric toxicity in neonatal rats is 7 to lasix contraindications 10 times that of adult rats. The concentration of LASIX in lasix contraindications biological fluids lasix contraindications associated lasix contraindications with lasix contraindications toxicity or death lasix contraindications is not known. Treatment of overdosage is supportive and consists of replacement of excessive fluid and electrolyte losses. Serum electrolytes, carbon dioxide level and blood pressure should be determined frequently. Adequate drainage must be assured in patients with urinary bladder outlet obstruction (such as prostatic hypertrophy). Hemodialysis does not accelerate furosemide elimination. TOP DOSAGE AND ADMINISTRATION Edema Therapy should be individualized according lasix contraindications to patient response to gain maximal therapeutic response and to determine lasix contraindications the minimal dose needed to maintain that response. Adults -- The usual initial dose of LASIX is 20 to 80 mg given lasix contraindications as a single dose. Ordinarily a prompt lasix contraindications diuresis ensues. If needed, the same dose can be administered 6 to 8 hours later lasix contraindications or the dose may be increased. The dose may be raised by 20 or 40 mg and given not sooner than 6 to 8 hours after lasix contraindications the previous dose until the desired diuretic lasix contraindications effect has been obtained. The individually determined single dose should then be given once or twice daily (eg, at 8 am and 2 pm). The dose of LASIX may be carefully titrated up to 600 mg/day in patients with clinically severe edematous states. Edema may be most efficiently and safely mobilized by giving LASIX on 2 to 4 consecutive days each week. When doses exceeding 80 mg/day are given for prolonged periods, careful clinical observation and laboratory monitoring are particularly advisable. (See PRECAUTIONS: Laboratory Tests.) Pediatric patients -- The usual initial dose of lasix contraindications oral LASIX in pediatric patients is 2 mg/kg body weight, given as a single dose. If the diuretic response is not satisfactory after the initial dose, dosage lasix contraindications may be increased lasix contraindications by 1 or 2 mg/kg no sooner than 6 to 8 hours lasix contraindications after the previous dose. Doses greater than 6 mg/kg body weight are not recommended. For maintenance therapy in lasix contraindications pediatric patients, the dose should be lasix contraindications adjusted to the minimum effective level. Hypertension Therapy lasix contraindications should lasix contraindications be individualized lasix contraindications according to the patient’s response lasix contraindications to gain maximal therapeutic response and to determine the minimal dose lasix contraindications needed to maintain the therapeutic response. Adults -- The usual lasix contraindications initial dose of LASIX for hypertension is 80 mg, usually divided into 40 mg twice a day. Dosage should then be adjusted lasix contraindications according to response. If response is not satisfactory, add lasix contraindications other antihypertensive agents. Changes in blood pressure lasix contraindications must be carefully monitored when LASIX is used with other antihypertensive drugs, especially lasix contraindications during initial therapy. To prevent excessive drop in blood pressure, the dosage of other agents lasix contraindications should be lasix contraindications reduced by lasix contraindications at least 50 percent when LASIX is added to the regimen. As the blood pressure falls under the potentiating effect of LASIX, a further reduction in dosage or even discontinuation of other antihypertensive drugs may be necessary. TOP HOW SUPPLIED LASIX (furosemide) Tablets 20 mg are supplied as white, oval, monogrammed tablets in Bottles of 100 (NDC 0039-0067-10), 500 (NDC 0039-0067-50), and 1000 (NDC 0039-0067-70). The 20 mg tablets are lasix contraindications imprinted with “Lasix®” on one lasix contraindications side and “HOECHST” on the other, or with “Lasix®” on one side. LASIX Tablets 40 mg are supplied as white, round, monogrammed, scored tablets in Bottles of 100 (NDC 0039-0060-13), 500 (NDC 0039-0060-50), 1000 (NDC 0039-0060-70), and Unit Dose Packs lasix contraindications of 100 (NDC 0039-0060-11). The 40 mg tablets are imprinted with “Lasix® lasix contraindications 40” lasix contraindications on one side and the Hoechst logo on the other, or lasix contraindications with “Lasix® 40” on one side. LASIX Tablets 80 mg are supplied as white, round, monogrammed, facetted edge lasix contraindications tablets in Bottles of 50 (NDC 0039-0066-05) lasix contraindications and 500 (NDC 0039-0066-50). The lasix contraindications 80 mg tablets are imprinted with “Lasix® 80” on one side and the Hoechst logo on the other, or with “Lasix® 80” on one side. Note: Dispense in well-closed, light-resistant containers. Exposure to light might cause a slight discoloration. Discolored tablets should not be lasix contraindications dispensed. Tested by USP Dissolution Test 2 Store at Controlled Room lasix contraindications Temperature 15º -30ºC (59º -86ºF). Rev. January 2004 Mfd. by: Patheon Pharmaceuticals Inc. Cincinnati, OH 45215 USA Mfd. for Aventis Pharmaceuticals NJ Bridgewater, NJ 08807 USA © 2004 Aventis Pharmaceuticals Inc. WARNING DESCRIPTION CLINICAL PHARMACOLOGY INDICATIONS AND USAGE CONTRAINDICATIONS WARNINGS PRECAUTIONS lasix contraindications ADVERSE REACTIONS lasix contraindications OVERDOSAGE DOSAGE AND ADMINISTRATION HOW SUPPLIED © 2004, Aventis Pharmaceuticals Inc. Legal Disclaimer Information and Privacy Policy Questions or comments? 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