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To find more information on specific conditions, please visit our partner sites: ADHD Issues (www.adhdissues.com) Alzheimer's Issues (www.alzheimersissues.com) Arthritis Issues (www.arthritisIssues.com) Bipolar Depression (www.bipolardepressioninfo.com) Breast Cancer Advice (www.breastcanceradvice.com) Adverse effects from hydrochlorothiazide Cancer Issues (www.cancerissues.com) Colon Cancer Today (www.coloncancertoday.com) Depression Issues (www.depressionissues.com) Diabetic Diets (www.diabeticdiets.org) Diabetic Life (www.diabeticlife.org) Digestive Facts (www.digestivefacts.com) Erectile Facts (www.erectilefacts.com) Heart Info (www.heartinfo.org) Liver Facts (www.liverfacts.com) Lung Cancer Issues (www.lungcancerissues.com) Men's Sexual Health (www.menssexhealth.com) Migraine Issues (www.migraineissues.com) My Allergies (www.myallergies.org) Prostate Cancer Issues (www.prostatecancerissues.com) Reduce Cholesterol (www.reducecholesterol.org) Reflux Issues (www.refluxissues.com) Sexual Health Issues (www.sexualhealthissues.com) Women's Health Issues (www.womenshealthissues.net) Entrez PubMed My NCBI[Sign In] [Register] All Databases PubMed Nucleotide Protein Genome Structure OMIM PMC Journals Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes Conserved Domains 3D Domains Gene Genome Project GENSAT GEO Profiles GEO DataSets HomoloGene Journals MeSH NCBI Web Adverse effects from hydrochlorothiazide Site NLM Catalog OMIM PMC PopSet Probe PubChem BioAssay PubChem Compound PubChem Substance SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard Details About Entrez Text Version Entrez PubMed Overview Help | FAQ Tutorial New/Noteworthy E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher Clinical Queries Special Queries LinkOut My NCBI (Cubby) Related Resources Order Documents NLM Catalog NLM Gateway TOXNET Consumer Health Clinical Alerts ClinicalTrials.gov PubMed Central Display Summary Brief Abstract Citation MEDLINE XML UI List LinkOut ASN.1 Related Articles Cited Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Adverse effects from hydrochlorothiazide Links Gene Links Gene (GeneRIF) Links Genome Adverse effects from hydrochlorothiazide Links Project Links GENSAT Links GEO Profile Links HomoloGene Links Nucleotide Links OMIM Links BioAssay Links Compound Links Compound via MeSH Substance Links Substance via MeSH PMC Links Cited in PMC PopSet Links Probe Links Protein Links SNP Links Structure Links UniGene Links UniSTS Links Show 5 10 20 50 100 200 500 Sort by Author Journal Pub Date Send Adverse effects from hydrochlorothiazide to Text File Clipboard E-mail Order All: 1 Review: 0 1: Diabet Med. 2003 Sep;20(9):708-12. Related Articles, Links Comparative metabolic effects of hydrochlorothiazide and indapamide in hypertensive diabetic patients receiving ACE inhibitor therapy.Krum H, Skiba M, Gilbert RE.National Health & Medical Research Council of Australia Centre of Clinical Research Excellence in Therapeutics, Department Adverse effects from hydrochlorothiazide of Epidemiology & Preventive Medicine, Monash University/Alfred Hospital, Prahran, Victoria, Australia. henry.krum@med.monash.edu.auBACKGROUND: ACE inhibitors, when used as monotherapy, are frequently unable to adequately control blood pressure in diabetic patients. A diuretic may be added; however, thiazide diuretics, but not indapamide, have been associated with adverse metabolic effects. Whether these effects also apply to thiazides when administered in the currently used lower doses, and whether they differ from indapamide in their metabolic effects, particularly when used in combination with Adverse effects from hydrochlorothiazide an ACE inhibitor in diabetic patients, has not been previously studied. METHODS: We conducted a prospective, Adverse effects from hydrochlorothiazide randomized, open-label, blinded endpoint Adverse effects from hydrochlorothiazide crossover study comparing the metabolic responses to the addition of either hydrochlorothiazide (HCTZ) or indapamide, in 18 diabetic hypertensive patients receiving ACE inhibitor monotherapy for hypertension. Patients stabilized on fosinopril 20 mg/day were randomized to receive either HCTZ 12.5 mg od or indapamide 2.5 mg od for 8 weeks, then crossed over to the alternate therapy for a further 8-week period. Blood pressure, heart rate and metabolic assessments were performed at the end of each 8-week treatment period. RESULTS: Seated Adverse effects from hydrochlorothiazide and standing systolic and diastolic Adverse effects from hydrochlorothiazide blood pressures Adverse effects from hydrochlorothiazide were not different between HCTZ or indapamide when added to fosinopril, nor was the fasting lipid profile or urinary Adverse effects from hydrochlorothiazide albumin : creatinine ratio. Plasma potassium was lower with indapamide compared with HCTZ treatment (indapamide 4.3+/-0.1 mmol/l; HCTZ 4.5+/-0.1 mmol/l, P<0.01) and HbA1c was higher with indapamide than with HCTZ therapy (indapamide 7.8+/-0.4%; HCTZ 7.2+/-0.3%, P<0.01). CONCLUSIONS: Hydrochlorothiazide 12.5 mg/day, when added to Adverse effects from hydrochlorothiazide background ACE inhibitor therapy with fosinopril in hypertensive diabetic patients, resulted in Adverse effects from hydrochlorothiazide a metabolic profile that was similar, if not superior on certain parameters, in comparison with indapamide 2.5 mg/day.Publication Types: Clinical Trial Multicenter Study Randomized Controlled Trial PMID: 12925048 [PubMed - indexed for MEDLINE] Display Summary Brief Abstract Citation MEDLINE XML UI List LinkOut ASN.1 Related Articles Cited Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Gene (GeneRIF) Links Genome Links Project Links GENSAT Links GEO Profile Links HomoloGene Links Nucleotide Links OMIM Links BioAssay Links Compound Links Compound via Adverse effects from hydrochlorothiazide MeSH Substance Links Substance via MeSH PMC Links Cited in PMC PopSet Links Probe Links Protein Links SNP Links Structure Links UniGene Links UniSTS Links Show 5 10 20 50 100 200 500 Sort by Author Journal Pub Date Send to Text File Clipboard E-mail Order Write to the Help Desk NCBI | NLM | NIH Department of Health & Human Services Privacy Statement | Freedom of Information Act | Disclaimer Jul 18 2005 15:16:48 Entrez PubMed My NCBI[Sign In] [Register] All Databases PubMed Nucleotide Protein Genome Structure OMIM PMC Journals Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes Conserved Domains 3D Domains Gene Genome Project GENSAT GEO Profiles GEO DataSets HomoloGene Journals MeSH NCBI Web Site NLM Catalog OMIM PMC PopSet Probe PubChem BioAssay PubChem Compound PubChem Substance SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard Details About Entrez Text Version Entrez PubMed Overview Help | FAQ Tutorial New/Noteworthy E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher Clinical Queries Special Queries LinkOut My NCBI (Cubby) Related Resources Order Documents NLM Catalog NLM Gateway TOXNET Consumer Health Clinical Alerts ClinicalTrials.gov PubMed Central Display Summary Brief Abstract Citation MEDLINE XML UI List LinkOut ASN.1 Related Articles Cited Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Gene (GeneRIF) Links Genome Links Project Links GENSAT Links GEO Profile Links HomoloGene Links Nucleotide Links OMIM Links BioAssay Links Compound Links Compound via MeSH Substance Links Substance via MeSH PMC Links Cited in PMC PopSet Links Probe Links Protein Links SNP Links Structure Links UniGene Links UniSTS Links Show 5 10 20 50 100 200 500 Sort by Author Journal Pub Date Send to Text File Clipboard E-mail Order All: 1 Review: 0 1: N Engl J Med. 1989 Sep 28;321(13):868-73. Related Articles, Links Comment in: N Engl J Med. 1990 Mar 15;322(11):776-7. A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension.Pollare T, Lithell H, Berne C.Department of Geriatrics, Uppsala University, Sweden.It has been suggested that the metabolic side effects of antihypertensive drugs are responsible for their failure to reduce cardiovascular morbidity in patients with Adverse effects from hydrochlorothiazide hypertension. Therefore, in 50 patients with essential hypertension, we performed a randomized, double-blind, crossover study comparing the effects of carbohydrate and lipid metabolism of captopril (mean [+/- SD] dose, 81 +/- 24 mg per day) and hydrochlorothiazide Adverse effects from hydrochlorothiazide (40 Adverse effects from hydrochlorothiazide +/- 12 mg per day) over two four-month treatment periods. Captopril increased the insulin-mediated disposal of glucose, as compared with placebo, from 5.7 +/- 2.4 to 6.3 +/- 2.5 mg per kilogram Adverse effects from hydrochlorothiazide of body weight per minute (P Adverse effects from hydrochlorothiazide less than 0.05), whereas hydrochlorothiazide caused a decrease from 6.4 +/- 2.0 to 5.7 +/- 1.9 (P less than 0.01). Captopril had no effect on the basal insulin concentration, but it decreased the late (30- to 90-minute) insulin response to glucose and increased the early (2- to 6-minute) insulin peak. Hydrochlorothiazide increased the basal insulin concentration and the late insulin response to glucose. These findings may be explained by Adverse effects from hydrochlorothiazide an increase in insulin sensitivity with captopril and a decrease with hydrochlorothiazide. Little or no change was seen in serum lipid or lipoprotein levels during Adverse effects from hydrochlorothiazide treatment with captopril, whereas hydrochlorothiazide caused significant increases in serum total (5 percent) and low-density lipoprotein (6 percent) cholesterol levels and total (15 percent) and very-low-density lipoprotein (25 percent) triglyceride levels, as compared with placebo (P less than 0.01 for all comparisons). We conclude that hydrochlorothiazide for the treatment of essential hypertension has adverse effects on glucose and lipid metabolism. It is possible, but not proved in this study, that these changes may contribute to the risk for diabetes mellitus and coronary heart disease. In contrast, captopril appears to have beneficial or no effects on glucose and lipid metabolism.Publication Types: Clinical Trial Randomized Controlled Trial MeSH Terms: Blood Glucose/metabolism* Blood Pressure/drug effects Captopril/adverse effects Captopril/pharmacology* Captopril/therapeutic use Comparative Study Double-Blind Method Female Heart Rate/drug effects Humans Hydrochlorothiazide/adverse effects Hydrochlorothiazide/pharmacology* Hydrochlorothiazide/therapeutic use Hypertension/drug therapy* Hypertension/physiopathology Insulin/blood Lipids/blood* Lipoproteins/blood Male Middle Aged Random Allocation Research Support, Non-U.S. Gov't Substances: Blood Glucose Lipids Lipoproteins Insulin Hydrochlorothiazide Captopril PMID: 2671740 [PubMed - indexed for MEDLINE] Display Summary Brief Abstract Citation MEDLINE XML UI List LinkOut ASN.1 Related Articles Cited Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Gene (GeneRIF) Links Genome Links Project Links GENSAT Links GEO Profile Links HomoloGene Links Nucleotide Links OMIM Links BioAssay Links Compound Links Compound via MeSH Substance Links Substance via MeSH PMC Links Cited in PMC PopSet Links Probe Links Protein Links SNP Links Structure Links UniGene Links UniSTS Links Show 5 10 20 50 100 200 500 Sort by Author Journal Pub Date Send to Text File Clipboard E-mail Order Write to the Help Desk NCBI | NLM | NIH Department of Health & Human Services Privacy Statement | Freedom of Information Act | Disclaimer Jul 18 2005 15:16:48 ZAPTO-CO TABLETS INDICATIONS CONTRA-INDICATIONS DOSAGE SIDE-EFFECTS PREGNANCY OVERDOSE IDENTIFICATION PATIENT INFORMATION ZAPTO-CO TABLETS SCHEDULING STATUS: S3 PROPRIETARY NAME (and dosage form): ZAPTO-CO Adverse effects from hydrochlorothiazide TABLETS COMPOSITION: Each tablet contains: Captopril 50 mg Hydrochlorothiazide 25 mg PHARMACOLOGICAL CLASSIFICATION: A 7.1.3 Other hypotensives. PHARMACOLOGICAL ACTION: This combination of an angiotensin converting enzyme (ACE) inhibitor (captopril) and a diuretic (hydrochlorothiazide) lowers blood pressure by different, though complementary mechanisms. With diuretic treatment, blood pressure and blood volume fall resulting in a rise in angiotensin II levels which tend to blunt the Adverse effects from hydrochlorothiazide hypotensive effect. Captopril blocks this rise in angiotensin II by, preventing the conversion of angiotensin to angiotensin II by inhibition of ACE. Because captopril reduces the production of aldosterone, its combination with hydrochlorothiazide may also minimise diuretic induced hypokalaemia. Hydrochlorothiazide acts Adverse effects from hydrochlorothiazide by reducing reabsorption of Adverse effects from hydrochlorothiazide electrolytes from the renal tubules thereby increasin, Adverse effects from hydrochlorothiazide the excretion of sodium and chloride ions and consequently of water. INDICATIONS: ZAPTO-CO tablets are indicated for the treatment of mild to moderate hypertension in adult patients who have been stabilized on the individual agents given in the same proportions. CONTRA-INDICATIONS: A history of previous hypersensitivity to captopril or hydrochlorothiazide. Patients hypersensitive to bumetanide, furosemide, carbonic anhydrase inhibitors or other sulfonamide type medications. Severe renal and/or hepatic insufficiency. Patients with aortic stenosis or outflow tract Adverse effects from hydrochlorothiazide obstruction. Patients with Addison's disease. Patients Adverse effects from hydrochlorothiazide with anuria. Patients with porphyria. Safety in lactation has not been established. Thiazide diuretics are excreted in breast milk. Treatment with hydrochlorothiazide can inhibit lactation. Safety in children less than 18 years of age has not been established. Pregnancy (see warnings) WARNINGS: Should a woman become pregnant while receiving ZAPTO-CO, the treatment must be Adverse effects from hydrochlorothiazide stopped promptly and an alternative medicine used. Adverse effects from hydrochlorothiazide Should a woman Adverse effects from hydrochlorothiazide contemplate Adverse effects from hydrochlorothiazide pregnancy, the Adverse effects from hydrochlorothiazide doctor should consider alternative medication. ACE-inihibitors pass through the placenta and can be presumed to cause disturbance in foetal blood pressure regulatory mechanisms. Oligohydramnios as well as hypotension, oliguria and anuria in newborns have been reported after administration of ACE-inihibitors in the second and third trimester Cases of defective skull ossification have been observed. Prematurity and low birth mass can occur. Angioedema: Angioedema involving the extremities, face, eyes, lips, mucous membranes, tongue, glottis or larynx has been reported. Patients should be advised to immediately report to their doctor any signs or symptoms suggesting angioedema Adverse effects from hydrochlorothiazide (swelling of face, eyes, lips, tongue, larynx and extremities; difficulty in swallowing or breathing; hoarseness) and to discontinue therapy. If angioedema involves the tongue, glottis or larynx, airway obstruction may occur and be Adverse effects from hydrochlorothiazide fatal. Emergency therapy, including but not necessarily limited to, subcutaneous administration of a 1:1000 solution of adrenaline should be promptly instituted. Swelling confined to the face, mucous membranes of the mouth, lips and extremities has usually resolved with discontinuation of therapy; some cases required medical therapy. Haematological: Neutropenia/Agranulocytosis, thrombocytopenia and anaemia have been reported in patients receiving captopril, usually within three months after treatment has started. Captopril should not be used routinely in patients with pre-existing impaired renal function, collagen vascular disease or who are receiving immunosuppressant therapy, treatment with allopurinol or procainamide, or a combination of Adverse effects from hydrochlorothiazide these complicating Adverse effects from hydrochlorothiazide factors, because the occurrence of neutropenia has been almost exclusively limited to this group. Thus for patients in this group on therapy, white blood Adverse effects from hydrochlorothiazide cell Adverse effects from hydrochlorothiazide and differential counts should be performed prior to therapy, every 2 weeks during the first 3 months, and periodically thereafter. Some of these patients developed serious infections which in a few instances did not respond to intensive antibiotic therapy. During treatment all patients should be instructed to report any sign of infection (eg persistent sore throat, fever), when a differential blood cell count should be performed. Captopril and hydrochlorothiazide and other concomitant medication Adverse effects from hydrochlorothiazide should be withdrawn if neutropenia (neutrophils less than 1000/mm³) is detected or suspected. In most patients neutrophil counts rapidly returned to normal upon discontinuing the medication. Proteinuriahas been reported in patients receiving captopril, but this has been predominantly in those who had prior renal disease. Although membranous glomerulopathy was found in biopsies taken from proteinuric patients, a causal relationship to captopril has not been established. Adverse effects from hydrochlorothiazide For patients with renal disease, patients with Adverse effects from hydrochlorothiazide prior renal disease urinary protein estimations (dipstick) should be done prior to treatment and periodically thereafter. Some patients with renal disease, particularly those with bilateral renal artery stenosis may develop increases in blood urea and serum creatinine after reduction of blood pressure with captopril and hydrochlorothiazide. Azotemia may be induced by thiazide in patients with impaired Adverse effects from hydrochlorothiazide renal function. Captopril and hydrochlorothiazide therefore would not be appropriate for patients with renal impairment since loop diuretics rather than a thiazide are preferred for such patients. In patients with Adverse effects from hydrochlorothiazide impaired renal function cumulative effects of thiazide may develop. Renal impairment: ZAPTO-CO is not recommended for use in renal impairment. DOSAGE AND DIRECTIONS FOR USE: ADULTS: Dosage must be Adverse effects from hydrochlorothiazide individualized. ZAPTO-CO should be taken one hour before food intake. In the treatment of hypertension, captopril and hydrochlorothiazide may be used for patients requiring individual doses of captopril and a diuretic. The usual dosage is one tablet once a day. If a satisfactory reduction of blood pressure has not been achieved after four weeks, the dose of captopril may be increased to not more than 150 mg per day, in divided Adverse effects from hydrochlorothiazide daily doses. The dose of captopril must Adverse effects from hydrochlorothiazide be increased by the addition of captopril on its own. A significant number of patients may achieve long-term control of their blood pressure on half a tablet (captopril 25 mg/hydrochlorothiazide 12,5 mg) per day, particularly in the elderly patients. SIDE-EFFECTS AND SPECIAL PRECAUTIONS: CAPTOPRIL: Adverse effects tend to be dose-related and more Adverse effects from hydrochlorothiazide frequent in patients with impaired renal function. The most common adverse effects are skin rashes which may be accompanied by pruritus, fever, and eosinophilia, a persistent dry cough; and taste disturbances, which may sometimes be associated with weight loss. The skin rash is usually pruritic and maculopapular and generally occurs during the first 4 weeks of treatment. Proteinuria has occurred mainly in patients with existing renal disease and some of these patients develop the Adverse effects from hydrochlorothiazide nephrotic syndrome. Evidence of deterioration in renal Adverse effects from hydrochlorothiazide function, including increasing blood concentrations Adverse effects from hydrochlorothiazide of urea and creatinine, and reversible acute renal failure have been reported in patients with existing renal or renovascular dysfunction and may be aggravated by hypovolemia. Captopril administration has also been associated with increases in blood-potassium concentrations. Transient hypotension may occur at the start of therapy particularly in patients with congestive heart Adverse effects from hydrochlorothiazide failure and in sodium- or Adverse effects from hydrochlorothiazide volume-depleted patients. This can be minimized by Adverse effects from hydrochlorothiazide starting with a low dose of captopril and giving the initial dose at night. Other adverse effects reported with captopril include angioedema (see warnings), tachycardia, headache, paraesthesias, lymphadenopathy, photosensitivity, stomatitis, gastro-intestinal irritation, abdominal pain and, less frequently, cases of hepatocellular Adverse effects from hydrochlorothiazide injury and jaundice. Renal function should be assessed in all patients prior to administration of captopril. Regular white blood cell counts should be made during the initial stages of therapy. Since raised serum-potassium concentrations may develop, potassium-sparing diuretics, potassium supplements, or Adverse effects from hydrochlorothiazide potassium-containing salt substitutes should be used with caution. The hypotensive effect of captopril is enhanced by diuretics and other antihypertensive agents. Indomethacin has been shown to reduce or abolish the hypotensive action of captopril, and salicylates appear to produce a similar effect. Captopril may Adverse effects from hydrochlorothiazide cause false positive results in tests for acetone in urine. HYDROCHLOROTHIAZIDE Hydrochlorothiazide may cause Adverse effects from hydrochlorothiazide a number of metabolic disturbances. It may provoke hyperglycaemia and glycosuria in diabetic and other susceptible patients. It may cause hyperuricaemia and precipitate attacks of gout in some patients. Administration of hydrochlorothiazide may be associated with electrolyte imbalances including hypochloraemic alkalosis, hyponatraemia, and Adverse effects from hydrochlorothiazide hypokalaemia. Hypokalaemia intensities the effect of Adverse effects from hydrochlorothiazide digitalis on cardiac muscle and administration of digitalis or its glycosides may have to be temporarily suspended. Patients with cirrhosis of the liver are particularly at Adverse effects from hydrochlorothiazide risk from hypokalaemia. Hyponatraemia Adverse effects from hydrochlorothiazide may occur in patients with severe congestive heart failure who are very oedematous, particularly with large doses in conjunction with restricted salt in the diet. The urinary excretion of calcium is reduced. Hypomagnesaemia has also occurred. Adverse changes in plasma lipids have also been noted but their clinical significance is unclear. Signs of electrolyte imbalance include dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pain and cramps, seizures, oliguria, and gastro-intestinal disturbances. Other side-effects include anorexia, gastric irritation, nausea, vomiting, constipation, diarrhoea, headache, dizziness, photosensitivity reactions, postural hypotension, paraesthesia, impotence, and yellow Adverse effects from hydrochlorothiazide vision. Hypersensitivity reactions include skin rashes, pulmonary oedema, and pneumonitis. Cholestatic jaundice, pancreatitis, and blood dyscrasias including thrombocytopenia and, less frequently, granulocytopenia, leucopenia, and aplastic and haemolytic anaemia have been reported. Hydrochlorothiazide should be used with caution in patients with impaired hepatic function since it may increase the risk of hepatic encephalopathy. It should also be given with caution in renal impairment since it can further reduce renal function. Blood-glucose concentrations should be monitored in patients taking antidiabetic agents, since requirements may change. All patients should be carefully observed for signs of fluid and electrolyte imbalance, especially in presence of vomiting or during parenteral fluid therapy. Elderly Adverse effects from hydrochlorothiazide patients are particularly susceptible Adverse effects from hydrochlorothiazide to electrolyte imbalance. There is a possibility that hydrochlorothiazide may Adverse effects from hydrochlorothiazide exacerbate or activate systemic lupus erythematosus in susceptible patients. Hydrochlorothiazide may enhance the toxicity of digitalis glycosides by depleting serum-potassium concentrations. It may enhance the neuromuscular blocking action of competitive muscle relaxants, such as tubocurarine. It may enhance the effect of antihypertensive agents, while postural hypotension associated Adverse effects from hydrochlorothiazide with hydrochlorothiazide therapy may be enhanced by concomitant ingestion of alcohol, barbiturates, or opioids. The potassium-depleting effect of hydrochlorothiazide may be enhanced by corticosteroids, corticotrophin, or carbenoxolone. Concomitant administration of hydrochlorothiazide and lithium is not generally recommended since the association may lead to toxic blood concentrations of lithium. Hydrochlorothiazide crosses the placenta and there have been reports of neonatal jaundice, thrombocytopenia, and Adverse effects from hydrochlorothiazide electrolyte imbalances following maternal treatment. Reductions in maternal blood volume could also adversely affect placental perfusion. KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT: Overdosage Adverse effects from hydrochlorothiazide will lead to hypotension and Adverse effects from hydrochlorothiazide electrolyte depletion. Volume expansion with an intravenous infusion of sodium chloride injection is recommended to normalize the blood pressure. Captopril can be removed by haemodialysis. Further treatment is symptomatic and supportive. IDENTIFICATION: An orange biconvex, bisected tablet engraved with a mortar and pestle. PRESENTATION: Blister packs of 28 tablets each. STORAGE INSTRUCTIONS: Store below 25°C in well-closed Adverse effects from hydrochlorothiazide containers. KEEP OUT OF REACH OF CHILDREN. REGISTRATION NUMBER: 28/7.1.3/0603 NAME AND BUSINESS ADDRESS OF APPLICANT: Pharmacare Limited 7 Fairclough Road Korsten PORT ELIZABETH 6001 DATE OF PUBLICATION OF THIS PACKAGE INSERT: 10 June 1994 G991 KOHLER C&P PE. SAEPI Adverse effects from hydrochlorothiazide HOME PAGE TRADE Adverse effects from hydrochlorothiazide NAME INDEX GENERIC NAME INDEX FEEDBACK Information presented by Malahyde Information Systems © Copyright 1996,1997,1998 buy tenormin cost usa new prozac online |